CRCGN011_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulforaphane 4.99 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

203 genes differentially expressed following the CRCGN011_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
TXNRD1 thioredoxin reductase 1 6.4016
CYCS cytochrome c, somatic 6.28465
RPP38 ribonuclease P/MRP 38kDa subunit 5.4038
MYLK myosin light chain kinase 4.8257
ADRB2 adrenoceptor beta 2, surface 4.66275
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.6482
BIRC2 baculoviral IAP repeat containing 2 4.6182
KIFBP kinesin family binding protein 4.58535
E2F2 E2F transcription factor 2 4.5396
TLR4 toll-like receptor 4 4.47945
NOTCH1 notch 1 4.32885
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.29975
ABHD4 abhydrolase domain containing 4 4.27425
GARRE1 granule associated Rac and RHOG effector 1 4.26535
CASP10 caspase 10, apoptosis-related cysteine peptidase 4.09363
UGDH UDP-glucose 6-dehydrogenase 3.7918
KEAP1 kelch-like ECH-associated protein 1 3.69185
SQOR sulfide quinone oxidoreductase 3.3875
PLSCR3 phospholipid scramblase 3 3.1372
SSBP2 single-stranded DNA binding protein 2 3.06978
FAM222B family with sequence similarity 222, member B 3.011
SAA2 serum amyloid A2 2.98548
JADE2 jade family PHD finger 2 2.91565
PIH1D1 PIH1 domain containing 1 2.85785
HOOK2 hook microtubule-tethering protein 2 2.8516
MMP7 matrix metallopeptidase 7 2.84505
ZBTB25 zinc finger and BTB domain containing 25 2.8436
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.79315
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.7691
INPP1 inositol polyphosphate-1-phosphatase 2.64305
TIAM1 T-cell lymphoma invasion and metastasis 1 2.64015
ERCC6 excision repair cross-complementation group 6 2.61345
FOSL1 FOS-like antigen 1 2.59315
GMPR guanosine monophosphate reductase 2.52075
TRIB1 tribbles pseudokinase 1 2.49835
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.49515
NMU neuromedin U 2.49415
LUZP4 leucine zipper protein 4 2.4517
ASB6 ankyrin repeat and SOCS box containing 6 2.4493
KLC3 kinesin light chain 3 2.44235
PARP2 poly (ADP-ribose) polymerase 2 2.4388
PRELP proline/arginine-rich end leucine-rich repeat protein 2.41625
MRPL42 mitochondrial ribosomal protein L42 2.401
IDO1 indoleamine 2,3-dioxygenase 1 2.38675
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.3752
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.37435
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.3702
TESPA1 thymocyte expressed, positive selection associated 1 2.36835
LOC122526780 uncharacterized LOC122526780 2.36015
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.3598
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.3368
GLRX glutaredoxin (thioltransferase) 2.33585
ZNF672 zinc finger protein 672 2.3121
GJB4 gap junction protein, beta 4, 30.3kDa 2.312
MAGEC1 melanoma antigen family C1 2.3082
RPP30 ribonuclease P/MRP 30kDa subunit 2.3058
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.2992
TMEM126B transmembrane protein 126B 2.2911
MRPL35 mitochondrial ribosomal protein L35 2.2897
TNIP1 TNFAIP3 interacting protein 1 2.2875
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.2841
PFDN2 prefoldin subunit 2 2.28385
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.27352
TFCP2L1 transcription factor CP2-like 1 2.2624
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.2623
GPR173 G protein-coupled receptor 173 2.2521
TCF20 transcription factor 20 (AR1) 2.24415
HLA-DRA major histocompatibility complex, class II, DR alpha 2.23997
NECAB2 N-terminal EF-hand calcium binding protein 2 2.23395
SCYL3 SCY1-like 3 (S. cerevisiae) 2.20478
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.20185
HBE1 hemoglobin, epsilon 1 2.19215
COLEC10 collectin sub-family member 10 (C-type lectin) 2.18685
GTPBP3 GTP binding protein 3 (mitochondrial) 2.1866
MRPS17 mitochondrial ribosomal protein S17 2.18545
KLF1 Kruppel-like factor 1 (erythroid) 2.18135
WDR4 WD repeat domain 4 2.1724
MED31 mediator complex subunit 31 2.1573
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.12945
GPR132 G protein-coupled receptor 132 2.12605
IL22 interleukin 22 2.1245
GYPB glycophorin B (MNS blood group) 2.12333
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.12325
RGS10 regulator of G-protein signaling 10 2.11912
DAO D-amino-acid oxidase 2.1143
RMDN3 regulator of microtubule dynamics 3 2.114
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.11095
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.10225
DRP2 dystrophin related protein 2 2.0984
IFNA7 interferon, alpha 7 2.08985
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.08845
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.08835
TRIM31 tripartite motif containing 31 2.0849
SQSTM1 sequestosome 1 2.08275
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.08165
KRTAP5-2 keratin associated protein 5-2 2.0793
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.07765
EDA2R ectodysplasin A2 receptor 2.06945
POLR1G RNA polymerase I subunit G 2.06895
DHDDS dehydrodolichyl diphosphate synthase 2.06868
CXCR1 chemokine (C-X-C motif) receptor 1 2.0614
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.05508
CDC123 cell division cycle 123 2.0495
CHRM2 cholinergic receptor, muscarinic 2 2.04815
MISP mitotic spindle positioning 2.0441
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.03875
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.0376
CLTA clathrin, light chain A 2.03223
FAM124B family with sequence similarity 124B 2.0316
CORO2A coronin, actin binding protein, 2A 2.02975
PEX19 peroxisomal biogenesis factor 19 2.02953
HLA-DMB major histocompatibility complex, class II, DM beta 2.02625
GLB1 galactosidase, beta 1 2.0249
WNT2 wingless-type MMTV integration site family member 2 2.0241
IQSEC3 IQ motif and Sec7 domain 3 2.0223
LHX6 LIM homeobox 6 2.0218
STIM1 stromal interaction molecule 1 2.0205
DLEC1 deleted in lung and esophageal cancer 1 2.01953
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.01695
CTSS cathepsin S 2.00817
PREB prolactin regulatory element binding 2.00675
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.0062
CHD9NB CHD9 neighbor 2.0024

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
MAPK13 mitogen-activated protein kinase 13 -6.42725
PEG10 paternally expressed 10 -5.89437
COG7 component of oligomeric golgi complex 7 -5.59155
PLK1 polo-like kinase 1 -5.1898
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.86765
PGM1 phosphoglucomutase 1 -4.8037
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.75103
LDHD lactate dehydrogenase D -4.7055
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.6757
CD320 CD320 molecule -4.6345
EIF5 eukaryotic translation initiation factor 5 -4.29917
CCNB2 cyclin B2 -4.2585
TLCD3A TLC domain containing 3A -3.8516
GNAS GNAS complex locus -3.68123
TWF2 twinfilin actin binding protein 2 -3.505
NRIP1 nuclear receptor interacting protein 1 -3.23822
C5 complement component 5 -3.1912
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.1796
TBC1D31 TBC1 domain family, member 31 -2.92505
SLURP1 secreted LY6/PLAUR domain containing 1 -2.8889
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.8852
WASF1 WAS protein family, member 1 -2.839
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.82285
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.77828
KIF22 kinesin family member 22 -2.74477
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.73995
RNF167 ring finger protein 167 -2.7136
BCL7C B-cell CLL/lymphoma 7C -2.6974
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.6702
ELOVL4 ELOVL fatty acid elongase 4 -2.599
SOBP sine oculis binding protein homolog (Drosophila) -2.59805
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.59275
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.5774
SLC61A1 solute carrier family 61 member 1 -2.56765
USP11 ubiquitin specific peptidase 11 -2.5144
ATAD2 ATPase family, AAA domain containing 2 -2.50675
LOC124907782 dual specificity protein phosphatase 22 -2.5027
PPP4C protein phosphatase 4, catalytic subunit -2.47645
MATN2 matrilin 2 -2.4709
MSMO1 methylsterol monooxygenase 1 -2.45435
IL36RN interleukin 36 receptor antagonist -2.44385
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.39585
SNX17 sorting nexin 17 -2.38905
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.36465
UBFD1 ubiquitin family domain containing 1 -2.3466
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.3463
SQLE squalene epoxidase -2.34472
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.30925
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.2684
MANF mesencephalic astrocyte-derived neurotrophic factor -2.26355
KLHDC2 kelch domain containing 2 -2.2622
CCNG2 cyclin G2 -2.25578
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.2342
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.21765
NAP1L2 nucleosome assembly protein 1-like 2 -2.19975
OXR1 oxidation resistance 1 -2.1943
DDIT4 DNA-damage-inducible transcript 4 -2.1914
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.1816
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.15045
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.1493
CCL21 chemokine (C-C motif) ligand 21 -2.1487
FBRS fibrosin -2.1445
REEP5 receptor accessory protein 5 -2.14403
MARF1 meiosis regulator and mRNA stability factor 1 -2.13775
YPEL1 yippee-like 1 (Drosophila) -2.1168
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.0984
TMEM267 transmembrane protein 267 -2.09575
ARHGAP17 Rho GTPase activating protein 17 -2.0901
RFWD3 ring finger and WD repeat domain 3 -2.088
REXO5 RNA exonuclease 5 -2.0868
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.08105
RANBP9 RAN binding protein 9 -2.0738
PALB2 partner and localizer of BRCA2 -2.05505
WDR26 WD repeat domain 26 -2.0508
MAMLD1 mastermind-like domain containing 1 -2.0318
DOCK3 dedicator of cytokinesis 3 -2.0128
ZNF155 zinc finger protein 155 -2.00815
SGCE sarcoglycan, epsilon -2.0028