CRCGN011_HEPG2_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulforaphane 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN011_HEPG2_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.0326
TREM1 triggering receptor expressed on myeloid cells 1 4.9785
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.91465
MYLK myosin light chain kinase 4.8702
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.70865
PEX11A peroxisomal biogenesis factor 11 alpha 4.62072
AMDHD2 amidohydrolase domain containing 2 4.0338
TXNRD1 thioredoxin reductase 1 3.9702
ABHD6 abhydrolase domain containing 6 3.81105
UGDH UDP-glucose 6-dehydrogenase 3.6329
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.4633
MAP7 microtubule-associated protein 7 3.37202
TLR4 toll-like receptor 4 3.2586
JADE2 jade family PHD finger 2 3.00052
ATP11B ATPase, class VI, type 11B 2.9115
PIH1D1 PIH1 domain containing 1 2.85875
SIRT3 sirtuin 3 2.73478
KEAP1 kelch-like ECH-associated protein 1 2.63205
ABHD4 abhydrolase domain containing 4 2.49865
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.43885
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.43835
CTSL cathepsin L 2.4119
LCN2 lipocalin 2 2.3314
ADAT1 adenosine deaminase, tRNA-specific 1 2.28815
ICAM1 intercellular adhesion molecule 1 2.28662
MEST mesoderm specific transcript 2.2671
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.2635
DPH2 DPH2 homolog (S. cerevisiae) 2.21515
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.14885
TRIM28 tripartite motif containing 28 2.11135
PADI2 peptidyl arginine deiminase, type II 2.1007
SMAD3 SMAD family member 3 2.05181

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.4432
THAP11 THAP domain containing 11 -5.34355
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.7939
VAT1 vesicle amine transport 1 -4.7672
CCNB2 cyclin B2 -4.63135
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.1516
EIF5 eukaryotic translation initiation factor 5 -4.03521
DNM1L dynamin 1-like -3.8659
LOC124907782 dual specificity protein phosphatase 22 -3.73745
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.2076
TBC1D31 TBC1 domain family, member 31 -2.86695
OXA1L oxidase (cytochrome c) assembly 1-like -2.71735
CDC25B cell division cycle 25B -2.4218
DDIT4 DNA-damage-inducible transcript 4 -2.3115
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.02349
BPHL biphenyl hydrolase-like (serine hydrolase) -2.001