CRCGN011_HEPG2_24H:J01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 21.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN011_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 5.9589
LCN2 lipocalin 2 5.0
UBQLN2 ubiquilin 2 4.8044
SMIM40 small integral membrane protein 40 4.69765
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.58185
STIMATE STIM activating enhancer 4.4793
ABHD6 abhydrolase domain containing 6 4.10862
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.67125
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.66867
LOC122526780 uncharacterized LOC122526780 3.6201
CGRRF1 cell growth regulator with ring finger domain 1 3.60235
CYCS cytochrome c, somatic 3.42875
PRR15L proline rich 15-like 3.09835
LSR lipolysis stimulated lipoprotein receptor 3.0691
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.97853
FASTKD5 FAST kinase domains 5 2.9742
COL11A1 collagen, type XI, alpha 1 2.8956
RALB v-ral simian leukemia viral oncogene homolog B 2.88217
ZNF84 zinc finger protein 84 2.6027
HMGA2 high mobility group AT-hook 2 2.5902
ZNF589 zinc finger protein 589 2.52127
RAB21 RAB21, member RAS oncogene family 2.48415
CNPY3 canopy FGF signaling regulator 3 2.4369
BMP4 bone morphogenetic protein 4 2.39665
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.3702
ILK integrin-linked kinase 2.3317
BAD BCL2-associated agonist of cell death 2.114
TFG TRK-fused gene 2.11305
MEST mesoderm specific transcript 2.08805
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.0749
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.04323
KIAA0232 KIAA0232 2.0233
ASPN asporin 2.0129

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.54445
VAT1 vesicle amine transport 1 -5.286
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.573
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4415
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.8208
ZMIZ1 zinc finger, MIZ-type containing 1 -3.80385
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.34365
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.05835
HMG20B high mobility group 20B -2.82203
GRWD1 glutamate-rich WD repeat containing 1 -2.8125
SPI1 Spi-1 proto-oncogene -2.5857
GNL1 guanine nucleotide binding protein-like 1 -2.55865
MAPK3 mitogen-activated protein kinase 3 -2.50935
CATSPERH catsper channel auxiliary subunit eta -2.46975
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.40141
HMX1 H6 family homeobox 1 -2.3993
DDIT4 DNA-damage-inducible transcript 4 -2.3536
CDC42SE1 CDC42 small effector 1 -2.3252
VCX3A variable charge, X-linked 3A -2.29288
TCF15 transcription factor 15 (basic helix-loop-helix) -2.29195
WASHC4 WASH complex subunit 4 -2.26312
ADGRD2 adhesion G protein-coupled receptor D2 -2.25865
EVX1 even-skipped homeobox 1 -2.25205
RIN1 Ras and Rab interactor 1 -2.2192
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -2.2116
TBKBP1 TBK1 binding protein 1 -2.21005
TRAPPC14 trafficking protein particle complex subunit 14 -2.20035
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.1974
BBC3 BCL2 binding component 3 -2.1876
EXTL1 exostosin-like glycosyltransferase 1 -2.1741
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -2.16555
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.16145
NXF2B nuclear RNA export factor 2B -2.14197
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.13925
TBC1D31 TBC1 domain family, member 31 -2.12925
NUP155 nucleoporin 155kDa -2.1232
DALRD3 DALR anticodon binding domain containing 3 -2.11825
TWNK twinkle mtDNA helicase -2.1151
BRIX1 BRX1, biogenesis of ribosomes -2.10475
TLE6 transducin-like enhancer of split 6 -2.09215
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -2.06537
GRTP1 growth hormone regulated TBC protein 1 -2.06015
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.0595
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.05015
WDR76 WD repeat domain 76 -2.01705
BPHL biphenyl hydrolase-like (serine hydrolase) -2.01595
HDAC7 histone deacetylase 7 -2.00905