CRCGN011_HEPG2_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 10.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

142 genes differentially expressed following the CRCGN011_HEPG2_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
UBQLN2 ubiquilin 2 10.0
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.30021
MAMLD1 mastermind-like domain containing 1 4.98065
PPARG peroxisome proliferator-activated receptor gamma 4.778
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.76985
NOTCH1 notch 1 4.75515
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.70215
RPP38 ribonuclease P/MRP 38kDa subunit 4.59505
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.50685
TLR4 toll-like receptor 4 4.4268
EPN2 epsin 2 4.4247
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 4.4244
PEX11A peroxisomal biogenesis factor 11 alpha 4.282
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.71865
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.5518
GPER1 G protein-coupled estrogen receptor 1 3.41852
SSBP2 single-stranded DNA binding protein 2 3.11333
KCTD9 potassium channel tetramerization domain containing 9 3.0148
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.994
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.73172
FASTKD5 FAST kinase domains 5 2.65295
EPHA3 EPH receptor A3 2.57385
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.5429
MELTF melanotransferrin 2.5316
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.5241
TMEM40 transmembrane protein 40 2.51105
GLRA2 glycine receptor, alpha 2 2.49365
CNGB3 cyclic nucleotide gated channel beta 3 2.48765
GCLM glutamate-cysteine ligase, modifier subunit 2.48005
GPATCH8 G patch domain containing 8 2.45022
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.43765
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.42575
MAGEF1 melanoma antigen family F1 2.4206
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.4181
CCNF cyclin F 2.3668
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.35818
ZNF750 zinc finger protein 750 2.35365
KIAA1549L KIAA1549-like 2.34435
COL21A1 collagen, type XXI, alpha 1 2.343
KAT2B K(lysine) acetyltransferase 2B 2.3246
TECPR2 tectonin beta-propeller repeat containing 2 2.31315
CDC45 cell division cycle 45 2.3031
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.2918
RGS18 regulator of G-protein signaling 18 2.28925
PTHLH parathyroid hormone-like hormone 2.28555
HMGA2 high mobility group AT-hook 2 2.27895
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.26405
MTM1 myotubularin 1 2.25443
KRT12 keratin 12, type I 2.2423
ZNF250 zinc finger protein 250 2.2371
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.23465
FBXO3 F-box protein 3 2.2267
MINDY3 MINDY lysine 48 deubiquitinase 3 2.22055
STX11 syntaxin 11 2.21125
OMG oligodendrocyte myelin glycoprotein 2.20605
MAGEC3 melanoma antigen family C3 2.19725
MCM3 minichromosome maintenance complex component 3 2.1891
BARX2 BARX homeobox 2 2.1887
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2.18515
CCDC25 coiled-coil domain containing 25 2.1666
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2.16226
IRS4 insulin receptor substrate 4 2.15995
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.15745
TSHR thyroid stimulating hormone receptor 2.15607
GSTZ1 glutathione S-transferase zeta 1 2.14195
PACC1 proton activated chloride channel 1 2.13055
ZIC4 Zic family member 4 2.11935
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.1191
MXRA5 matrix-remodelling associated 5 2.11875
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.11492
IL3 interleukin 3 2.11175
FKBPL FK506 binding protein like 2.0971
KLF8 Kruppel-like factor 8 2.0892
ZCCHC2 zinc finger, CCHC domain containing 2 2.07825
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.0736
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.0711
MTNR1A melatonin receptor 1A 2.0519
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.0504
RXRG retinoid X receptor, gamma 2.0374
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.03344
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.03075
TG thyroglobulin 2.028
BMP5 bone morphogenetic protein 5 2.027
HSFX2 heat shock transcription factor family, X linked 2 2.02565
RBPMS RNA binding protein with multiple splicing 2.0177
CRLF1 cytokine receptor-like factor 1 2.01175
CCL23 chemokine (C-C motif) ligand 23 2.0113
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.01105
PILRA paired immunoglobin-like type 2 receptor alpha 2.01008
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.00257
TRIM9 tripartite motif containing 9 2.0001
RASL12 RAS-like, family 12 2.0

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.4482
ADI1 acireductone dioxygenase 1 -5.01055
KDM3A lysine (K)-specific demethylase 3A -4.9525
TRIB3 tribbles pseudokinase 3 -4.92435
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.8327
PECR peroxisomal trans-2-enoyl-CoA reductase -4.6279
GDF15 growth differentiation factor 15 -4.14625
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.6516
ZNF274 zinc finger protein 274 -3.60285
GNAS GNAS complex locus -3.58876
MVP major vault protein -3.3383
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.26815
WASHC4 WASH complex subunit 4 -3.14413
TRAPPC2L trafficking protein particle complex 2-like -3.094
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.08985
SPAG4 sperm associated antigen 4 -2.95485
GRWD1 glutamate-rich WD repeat containing 1 -2.71845
WASHC3 WASH complex subunit 3 -2.7164
CCNB2 cyclin B2 -2.64785
GALE UDP-galactose-4-epimerase -2.5983
CTNND1 catenin (cadherin-associated protein), delta 1 -2.59098
TRAPPC12 trafficking protein particle complex 12 -2.55255
ZW10 zw10 kinetochore protein -2.5194
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.44592
PGM1 phosphoglucomutase 1 -2.40795
IFT88 intraflagellar transport 88 -2.34065
CAB39 calcium binding protein 39 -2.3386
NRIP1 nuclear receptor interacting protein 1 -2.3056
NISCH nischarin -2.29625
CHPF chondroitin polymerizing factor -2.28585
BABAM2 BRISC and BRCA1 A complex member 2 -2.24438
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.2001
ZNF586 zinc finger protein 586 -2.19835
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.19225
NPDC1 neural proliferation, differentiation and control, 1 -2.14355
MTREX Mtr4 exosome RNA helicase -2.12385
ACD adrenocortical dysplasia homolog (mouse) -2.12383
CLDN6 claudin 6 -2.1159
TMEM268 transmembrane protein 268 -2.108
ITM2C integral membrane protein 2C -2.08975
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.07365
ITGB1BP1 integrin beta 1 binding protein 1 -2.04443
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.0403
CARS1 cysteinyl-tRNA synthetase 1 -2.03315
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.02195
CHMP1A charged multivesicular body protein 1A -2.0134
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.00265
ESYT1 extended synaptotagmin-like protein 1 -2.0019