CRCGN011_HEPG2_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 5.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

188 genes differentially expressed following the CRCGN011_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 5.42145
TAC4 tachykinin 4 (hemokinin) 5.3024
PPARG peroxisome proliferator-activated receptor gamma 5.2983
CXCL2 chemokine (C-X-C motif) ligand 2 5.07405
RRAGA Ras-related GTP binding A 5.06465
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.76345
ADRB2 adrenoceptor beta 2, surface 4.7057
MYLK myosin light chain kinase 4.6322
GHR growth hormone receptor 4.461
RPL39L ribosomal protein L39-like 4.38705
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2228
MUC1 mucin 1, cell surface associated 4.20007
ABHD6 abhydrolase domain containing 6 4.166
TREM1 triggering receptor expressed on myeloid cells 1 4.00815
LSR lipolysis stimulated lipoprotein receptor 4.0062
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.9584
MOK MOK protein kinase 3.89345
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.74522
MDM4 MDM4, p53 regulator 3.7108
E2F2 E2F transcription factor 2 3.6787
SSBP2 single-stranded DNA binding protein 2 3.58685
CBR1 carbonyl reductase 1 3.55765
NMU neuromedin U 3.2947
HDGFL3 HDGF like 3 3.26835
SNAP25 synaptosomal-associated protein, 25kDa 3.13608
FAM3C family with sequence similarity 3, member C 3.10535
DMTF1 cyclin D binding myb-like transcription factor 1 3.09782
GPER1 G protein-coupled estrogen receptor 1 3.0773
ECD ecdysoneless homolog (Drosophila) 3.0433
SH3YL1 SH3 and SYLF domain containing 1 2.9403
CCNF cyclin F 2.93578
MEST mesoderm specific transcript 2.90735
HEBP1 heme binding protein 1 2.8903
ADAM10 ADAM metallopeptidase domain 10 2.87878
TYRP1 tyrosinase-related protein 1 2.8697
SLBP stem-loop binding protein 2.8276
MLANA melan-A 2.80845
SRPX sushi-repeat containing protein, X-linked 2.7828
TIAM1 T-cell lymphoma invasion and metastasis 1 2.71668
FASTKD5 FAST kinase domains 5 2.61815
JADE2 jade family PHD finger 2 2.61665
DIPK1A divergent protein kinase domain 1A 2.60905
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.53415
ENTREP2 endosomal transmembrane epsin interactor 2 2.4971
LOXL1 lysyl oxidase-like 1 2.47865
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.47145
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.46695
ZNF589 zinc finger protein 589 2.45533
HMGN1 high mobility group nucleosome binding domain 1 2.4277
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.39845
MTA2 metastasis associated 1 family, member 2 2.38075
ENOPH1 enolase-phosphatase 1 2.3788
CREB1 cAMP responsive element binding protein 1 2.37656
HCRT hypocretin (orexin) neuropeptide precursor 2.3713
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.35728
HLA-DRA major histocompatibility complex, class II, DR alpha 2.35005
TXNL4B thioredoxin-like 4B 2.34625
STEAP4 STEAP family member 4 2.3283
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.3146
FOCAD focadhesin 2.3031
POSTN periostin, osteoblast specific factor 2.2947
MSH4 mutS homolog 4 2.28295
CSN1S1 casein alpha s1 2.2553
HBZ hemoglobin, zeta 2.1631
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.1567
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.1558
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.15495
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.13897
DEFB126 defensin, beta 126 2.128
LDHA lactate dehydrogenase A 2.1147
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 2.10383
ZNF343 zinc finger protein 343 2.09155
DERA deoxyribose-phosphate aldolase (putative) 2.08555
GPR22 G protein-coupled receptor 22 2.0851
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.08485
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.08015
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.06865
ADAM7 ADAM metallopeptidase domain 7 2.06815
STK17B serine/threonine kinase 17b 2.0605
PVALB parvalbumin 2.05725
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.0547
PLK1 polo-like kinase 1 2.054
CD36 CD36 molecule (thrombospondin receptor) 2.0353
ZBTB11 zinc finger and BTB domain containing 11 2.02995
DAO D-amino-acid oxidase 2.02935
DMXL1 Dmx-like 1 2.02775
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0174
NUP133 nucleoporin 133kDa 2.01675
HLA-DMA major histocompatibility complex, class II, DM alpha 2.00605
EPHA5 EPH receptor A5 2.00305
EDDM3B epididymal protein 3B 2.00105

decreased expression

Symbol Name Standardized Value
GTPBP8 GTP-binding protein 8 (putative) -7.5371
CCNB2 cyclin B2 -6.908
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.92535
SYNE2 spectrin repeat containing, nuclear envelope 2 -5.57475
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.2478
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.08755
THAP11 THAP domain containing 11 -5.0
ARID5B AT rich interactive domain 5B (MRF1-like) -4.66575
PCNA proliferating cell nuclear antigen -4.66275
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.32605
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.31705
TM9SF2 transmembrane 9 superfamily member 2 -4.2931
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.29
RPIA ribose 5-phosphate isomerase A -4.02895
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -3.9983
NT5DC2 5'-nucleotidase domain containing 2 -3.8575
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.7282
AKAP8 A kinase (PRKA) anchor protein 8 -3.67787
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.5788
BLMH bleomycin hydrolase -3.5494
PRKCD protein kinase C, delta -3.44345
MCM3 minichromosome maintenance complex component 3 -3.43135
CDC25B cell division cycle 25B -3.3968
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.2978
DYNLT3 dynein, light chain, Tctex-type 3 -3.15735
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.15595
WDR7 WD repeat domain 7 -3.1413
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.03964
PRCP prolylcarboxypeptidase (angiotensinase C) -2.98285
HCK HCK proto-oncogene, Src family tyrosine kinase -2.9521
AURKA aurora kinase A -2.94575
MCOLN1 mucolipin 1 -2.9211
GPC1 glypican 1 -2.90595
NCK2 NCK adaptor protein 2 -2.879
RPN1 ribophorin I -2.85105
GRWD1 glutamate-rich WD repeat containing 1 -2.8116
SRPRB signal recognition particle receptor, B subunit -2.7753
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.745
RNF167 ring finger protein 167 -2.70725
PGM1 phosphoglucomutase 1 -2.69865
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.63225
MPZL1 myelin protein zero-like 1 -2.60547
GSTM2 glutathione S-transferase mu 2 (muscle) -2.5851
HOXA5 homeobox A5 -2.5337
SCARA3 scavenger receptor class A, member 3 -2.51015
CARD9 caspase recruitment domain family, member 9 -2.49145
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.46725
TBX3 T-box 3 -2.46625
GID8 GID complex subunit 8 -2.45145
C1QA complement component 1, q subcomponent, A chain -2.44355
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.4365
PANK4 pantothenate kinase 4 -2.4289
GYG1 glycogenin 1 -2.41535
SCHIP1 schwannomin interacting protein 1 -2.40825
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -2.4006
JUN jun proto-oncogene -2.39778
WDR6 WD repeat domain 6 -2.3977
SLAMF8 SLAM family member 8 -2.38713
IFRD2 interferon-related developmental regulator 2 -2.36875
DEFA3 defensin, alpha 3, neutrophil-specific -2.3311
TCEAL4 transcription elongation factor A (SII)-like 4 -2.33045
POLK polymerase (DNA directed) kappa -2.3072
IRF3 interferon regulatory factor 3 -2.30315
DYSF dysferlin -2.2756
ZW10 zw10 kinetochore protein -2.2622
CLN5 ceroid-lipofuscinosis, neuronal 5 -2.24995
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.23035
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.23005
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.2139
S100A13 S100 calcium binding protein A13 -2.2103
S100A8 S100 calcium binding protein A8 -2.2068
SDC3 syndecan 3 -2.20305
RYK receptor-like tyrosine kinase -2.20203
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.19585
CLU clusterin -2.19337
TTK TTK protein kinase -2.19025
HIRIP3 HIRA interacting protein 3 -2.1717
ORC6 origin recognition complex, subunit 6 -2.1558
TXNDC15 thioredoxin domain containing 15 -2.15255
ADAMDEC1 ADAM-like, decysin 1 -2.14805
PNPO pyridoxamine 5'-phosphate oxidase -2.1454
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.14535
ATF5 activating transcription factor 5 -2.1127
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.09573
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.0942
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) -2.08985
CHMP4B charged multivesicular body protein 4B -2.07938
TNS2 tensin 2 -2.0775
TBXAS1 thromboxane A synthase 1 (platelet) -2.0742
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.07155
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.0695
COPS7B COP9 signalosome subunit 7B -2.06395
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.0411
RBFA ribosome binding factor A (putative) -2.03475
INTS9 integrator complex subunit 9 -2.02805
AUNIP aurora kinase A and ninein interacting protein -2.028
CGB8 chorionic gonadotropin, beta polypeptide 8 -2.02495