CRCGN011_HEPG2_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 2.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN011_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.5271
MOK MOK protein kinase 5.23385
BACE2 beta-site APP-cleaving enzyme 2 5.04395
CSK c-src tyrosine kinase 5.0
GSTZ1 glutathione S-transferase zeta 1 4.85635
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.809
ADRB2 adrenoceptor beta 2, surface 4.6298
CXCR4 chemokine (C-X-C motif) receptor 4 4.40443
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.259
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.05865
PFKL phosphofructokinase, liver 3.48798
PRKCH protein kinase C, eta 3.47368
GATA3 GATA binding protein 3 3.31813
TENT4A terminal nucleotidyltransferase 4A 3.2168
SSBP2 single-stranded DNA binding protein 2 3.20278
WDR7 WD repeat domain 7 3.15235
PMM2 phosphomannomutase 2 2.78055
EPHA3 EPH receptor A3 2.67347
TESK1 testis-specific kinase 1 2.64905
TTLL1 tubulin tyrosine ligase-like family member 1 2.61165
LMNB1 lamin B1 2.5404
MMP2 matrix metallopeptidase 2 2.5011
KIFBP kinesin family binding protein 2.45775
PGRMC2 progesterone receptor membrane component 2 2.45318
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.44135
CCNF cyclin F 2.4282
KIFC1 kinesin family member C1 2.426
TRAPPC10 trafficking protein particle complex 10 2.38057
CRELD2 cysteine-rich with EGF-like domains 2 2.3409
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.30695
GATD3 glutamine amidotransferase class 1 domain containing 3 2.3013
GPATCH8 G patch domain containing 8 2.23438
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.2303
SLBP stem-loop binding protein 2.17375
BCOR BCL6 corepressor 2.15365
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.1449
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.13155
LOC122526780 uncharacterized LOC122526780 2.1013
CRTAP cartilage associated protein 2.10085
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.0921
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.07805
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.07005
RCL1 RNA terminal phosphate cyclase-like 1 2.0634
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.06115
RAI14 retinoic acid induced 14 2.05125
MINDY3 MINDY lysine 48 deubiquitinase 3 2.03485
WDR76 WD repeat domain 76 2.0101

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.14405
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.3922
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.74675
LDHD lactate dehydrogenase D -4.5346
FGFR4 fibroblast growth factor receptor 4 -4.25187
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.91332
LOC124907782 dual specificity protein phosphatase 22 -3.5746
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.3893
OXA1L oxidase (cytochrome c) assembly 1-like -3.06055
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.78535
MVP major vault protein -2.53735
MRPL48 mitochondrial ribosomal protein L48 -2.5046
NISCH nischarin -2.3943
TPCN1 two pore segment channel 1 -2.3061
PRPF4 pre-mRNA processing factor 4 -2.3051
ITGB1BP1 integrin beta 1 binding protein 1 -2.25443
SPATA2 spermatogenesis associated 2 -2.2378
RPS5 ribosomal protein S5 -2.19215
TLCD3A TLC domain containing 3A -2.12185
TSPYL5 TSPY-like 5 -2.0957
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.09025
CADPS2 Ca++-dependent secretion activator 2 -2.04755
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.0467
LIMS2 LIM and senescent cell antigen-like domains 2 -2.04315
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.03765
HEATR1 HEAT repeat containing 1 -2.0343
ATXN2 ataxin 2 -2.01965
SPAG4 sperm associated antigen 4 -2.01585