CRCGN011_HEPG2_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 1.33 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN011_HEPG2_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 10.0
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 5.1042
MYLK myosin light chain kinase 4.76985
TLR4 toll-like receptor 4 4.7585
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.5651
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.24785
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.23347
TREM1 triggering receptor expressed on myeloid cells 1 4.20315
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.5219
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.5122
SSBP2 single-stranded DNA binding protein 2 3.51032
PMM2 phosphomannomutase 2 3.0008
GARRE1 granule associated Rac and RHOG effector 1 2.89805
MEST mesoderm specific transcript 2.89005
ADAT1 adenosine deaminase, tRNA-specific 1 2.84135
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.80685
DYNLT3 dynein, light chain, Tctex-type 3 2.7737
VGLL4 vestigial-like family member 4 2.71508
PLSCR3 phospholipid scramblase 3 2.62385
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.53632
RAB21 RAB21, member RAS oncogene family 2.37405
NOSIP nitric oxide synthase interacting protein 2.3436
BCAP31 B-cell receptor-associated protein 31 2.3041
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.3002
EDN1 endothelin 1 2.26085
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26032
CST5 cystatin D 2.24725
TLR2 toll-like receptor 2 2.19445
EPHA3 EPH receptor A3 2.17552
ADGRG1 adhesion G protein-coupled receptor G1 2.142
TENT4A terminal nucleotidyltransferase 4A 2.12995
KIAA1549L KIAA1549-like 2.12975
LAMB3 laminin, beta 3 2.12015
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.1175
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.10445
ZNHIT6 zinc finger, HIT-type containing 6 2.0745
FBP1 fructose-1,6-bisphosphatase 1 2.05855
RMC1 regulator of MON1-CCZ1 2.0517
DKC1 dyskeratosis congenita 1, dyskerin 2.0235
ADGRL4 adhesion G protein-coupled receptor L4 2.01215
PELI1 pellino E3 ubiquitin protein ligase 1 2.00755

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.5278
CCNB2 cyclin B2 -7.32275
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.9903
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.79265
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.50075
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.25175
GTPBP8 GTP-binding protein 8 (putative) -4.8406
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.81815
CD320 CD320 molecule -4.7515
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6187
FGFR4 fibroblast growth factor receptor 4 -4.0819
USP6NL USP6 N-terminal like -3.97625
GNAS GNAS complex locus -3.42354
TBCB tubulin folding cofactor B -3.39372
ADI1 acireductone dioxygenase 1 -3.3042
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.26495
PSRC1 proline/serine-rich coiled-coil 1 -2.98715
DERA deoxyribose-phosphate aldolase (putative) -2.96745
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.91577
MTA1 metastasis associated 1 -2.71062
ACLY ATP citrate lyase -2.7018
ZMIZ1 zinc finger, MIZ-type containing 1 -2.66765
KCTD7 potassium channel tetramerization domain containing 7 -2.52915
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.50505
TMEM147 transmembrane protein 147 -2.49925
BGLAP bone gamma-carboxyglutamate (gla) protein -2.49595
SQLE squalene epoxidase -2.49238
RAI14 retinoic acid induced 14 -2.4199
SNX11 sorting nexin 11 -2.41677
PTPRS protein tyrosine phosphatase, receptor type, S -2.28715
CAPNS1 calpain, small subunit 1 -2.284
MSMO1 methylsterol monooxygenase 1 -2.25325
LIN37 lin-37 DREAM MuvB core complex component -2.2466
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.23895
EIF5 eukaryotic translation initiation factor 5 -2.2365
CYTH3 cytohesin 3 -2.21565
ZNF692 zinc finger protein 692 -2.20205
ZNF146 zinc finger protein 146 -2.1896
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.16055
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.15735
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.15695
OSMR oncostatin M receptor -2.15605
PSENEN presenilin enhancer gamma secretase subunit -2.14805
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.12415
SLIRP SRA stem-loop interacting RNA binding protein -2.1149
TBC1D5 TBC1 domain family, member 5 -2.10812
MPV17L-BMERB1 MPV17L-BMERB1 readthrough -2.1078
ZBED2 zinc finger, BED-type containing 2 -2.1071
AQP8 aquaporin 8 -2.0797
DYNLL1 dynein, light chain, LC8-type 1 -2.07625
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.0615
LHX5 LIM homeobox 5 -2.0495
NCF4 neutrophil cytosolic factor 4, 40kDa -2.0402
CD79B CD79b molecule, immunoglobulin-associated beta -2.038
LTC4S leukotriene C4 synthase -2.03215
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.01455
CLCC1 chloride channel CLIC-like 1 -2.01425
ZNF276 zinc finger protein 276 -2.01235
KIF1A kinesin family member 1A -2.00465
NVL nuclear VCP-like -2.0038
MVD mevalonate (diphospho) decarboxylase -2.0