CRCGN011_HEPG2_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-oxo-1,1-dipropylhydrazine 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN011_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.39005
CYCS cytochrome c, somatic 6.10745
CIAO3 cytosolic iron-sulfur assembly component 3 5.3942
DENND2D DENN/MADD domain containing 2D 5.0815
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.77115
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.6972
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 4.44885
HDGFL3 HDGF like 3 4.36116
GATA3 GATA binding protein 3 4.2768
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.27495
NMU neuromedin U 3.9799
PMM2 phosphomannomutase 2 3.89125
MEST mesoderm specific transcript 3.78205
STIMATE STIM activating enhancer 3.72915
TIAM1 T-cell lymphoma invasion and metastasis 1 3.70875
COQ8A coenzyme Q8A 3.70455
HEBP1 heme binding protein 1 3.6977
ABHD6 abhydrolase domain containing 6 3.55485
TXNL4B thioredoxin-like 4B 3.4865
EVL Enah/Vasp-like 3.20435
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.02705
TENT4A terminal nucleotidyltransferase 4A 2.996
JADE2 jade family PHD finger 2 2.8005
GPATCH8 G patch domain containing 8 2.68775
TESK1 testis-specific kinase 1 2.5323
TES testin LIM domain protein 2.49075
SCRN1 secernin 1 2.4197
SNX7 sorting nexin 7 2.3567
ATP11B ATPase, class VI, type 11B 2.31595
EPHA3 EPH receptor A3 2.31173
ALAS1 5'-aminolevulinate synthase 1 2.3115
MMP2 matrix metallopeptidase 2 2.3105
EDN1 endothelin 1 2.25245
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.2016
GARRE1 granule associated Rac and RHOG effector 1 2.1757
FAIM Fas apoptotic inhibitory molecule 2.14625
RAI14 retinoic acid induced 14 2.1224
CHN1 chimerin 1 2.069
TFRC transferrin receptor 2.06463
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.0602
CAV2 caveolin 2 2.0334
TAC4 tachykinin 4 (hemokinin) 2.03145

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -7.5543
GDF15 growth differentiation factor 15 -5.88845
PUF60 poly-U binding splicing factor 60KDa -4.8583
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.84785
ADI1 acireductone dioxygenase 1 -4.75305
GRWD1 glutamate-rich WD repeat containing 1 -4.7424
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.66275
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.54465
CDC20 cell division cycle 20 -4.2155
TUBB6 tubulin, beta 6 class V -4.0992
FASTKD5 FAST kinase domains 5 -3.96905
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.92795
HMG20B high mobility group 20B -3.91295
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.7609
GNAS GNAS complex locus -3.70722
TM9SF2 transmembrane 9 superfamily member 2 -3.5832
FBXL12 F-box and leucine-rich repeat protein 12 -3.36215
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.06957
HEATR1 HEAT repeat containing 1 -3.00655
SCRIB scribbled planar cell polarity protein -2.88435
HABP4 hyaluronan binding protein 4 -2.8027
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.65195
RBM15B RNA binding motif protein 15B -2.5005
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.39335
CHIC2 cysteine-rich hydrophobic domain 2 -2.3679
SLC35B1 solute carrier family 35, member B1 -2.3669
RPS5 ribosomal protein S5 -2.3239
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.29145
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.2914
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.2655
ZBTB25 zinc finger and BTB domain containing 25 -2.2621
PRPF4 pre-mRNA processing factor 4 -2.2604
HMBOX1 homeobox containing 1 -2.22285
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.1607
ZNF16 zinc finger protein 16 -2.1176
HPD 4-hydroxyphenylpyruvate dioxygenase -2.1001
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.0538
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.0463
BOP1 block of proliferation 1 -2.0412
HLA-DMA major histocompatibility complex, class II, DM alpha -2.0412
PHF20L1 PHD finger protein 20-like 1 -2.0283
ZNF7 zinc finger protein 7 -2.0207
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.01805
SPAG4 sperm associated antigen 4 -2.0075
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.0074
MIA melanoma inhibitory activity -2.00135