CRCGN011_HEPG2_24H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trimethylaniline 21.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 10.0
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 7.4076
NMU neuromedin U 5.77055
CCL2 chemokine (C-C motif) ligand 2 5.33945
NOTCH1 notch 1 5.1205
ADRB2 adrenoceptor beta 2, surface 5.06945
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.75285
C2CD2 C2 calcium-dependent domain containing 2 4.7225
CSK c-src tyrosine kinase 4.66275
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.63675
PNKP polynucleotide kinase 3'-phosphatase 4.6249
GSTZ1 glutathione S-transferase zeta 1 4.62125
PPARG peroxisome proliferator-activated receptor gamma 4.39425
STIMATE STIM activating enhancer 4.30785
ABHD6 abhydrolase domain containing 6 4.08395
FZD7 frizzled class receptor 7 3.8582
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.77925
LOC122526780 uncharacterized LOC122526780 3.57785
SSBP2 single-stranded DNA binding protein 2 3.46225
SLC75A1 solute carrier family 75 member 1 3.40745
TRAK2 trafficking protein, kinesin binding 2 3.25588
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.2526
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.17615
GARRE1 granule associated Rac and RHOG effector 1 2.99665
WDTC1 WD and tetratricopeptide repeats 1 2.90897
SHB Src homology 2 domain containing adaptor protein B 2.88053
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.82125
BIRC2 baculoviral IAP repeat containing 2 2.808
IFT54 intraflagellar transport 54 2.74505
TESK1 testis-specific kinase 1 2.70775
MMP2 matrix metallopeptidase 2 2.6991
JCAD junctional cadherin 5 associated 2.62265
TENT4A terminal nucleotidyltransferase 4A 2.55645
AURKB aurora kinase B 2.4915
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.48705
CRELD2 cysteine-rich with EGF-like domains 2 2.43815
STEAP1B STEAP family member 1B 2.2804
SIL1 SIL1 nucleotide exchange factor 2.2797
FAM117A family with sequence similarity 117, member A 2.2566
MZB1 marginal zone B and B1 cell-specific protein 2.2538
CEP112 centrosomal protein 112kDa 2.22745
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.22595
HMG20A high mobility group 20A 2.20855
SPAG8 sperm associated antigen 8 2.20608
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.19845
WLS wntless Wnt ligand secretion mediator 2.19145
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.1867
ZNF155 zinc finger protein 155 2.17465
IRF7 interferon regulatory factor 7 2.1704
COL11A1 collagen, type XI, alpha 1 2.16978
JCHAIN joining chain of multimeric IgA and IgM 2.1667
BAK1 BCL2-antagonist/killer 1 2.1515
PLAAT2 phospholipase A and acyltransferase 2 2.137
HLA-DRA major histocompatibility complex, class II, DR alpha 2.135
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.129
NSUN5 NOP2/Sun domain family, member 5 2.11475
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.1003
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.06785
GPALPP1 GPALPP motifs containing 1 2.0662
NGFR nerve growth factor receptor 2.0638
CLEC10A C-type lectin domain family 10, member A 2.06215
DGCR6L DiGeorge syndrome critical region gene 6-like 2.02375

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -6.09685
PCNA proliferating cell nuclear antigen -4.9283
ADI1 acireductone dioxygenase 1 -4.68815
NT5DC2 5'-nucleotidase domain containing 2 -4.6091
MAP7 microtubule-associated protein 7 -4.40175
PGM1 phosphoglucomutase 1 -4.36315
GNAS GNAS complex locus -3.71324
RNF167 ring finger protein 167 -3.6872
ITGB1BP1 integrin beta 1 binding protein 1 -3.63705
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.55045
NRIP1 nuclear receptor interacting protein 1 -3.37402
LYPLA1 lysophospholipase I -3.25625
CCNB2 cyclin B2 -3.081
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.949
TRAP1 TNF receptor-associated protein 1 -2.8605
FOS FBJ murine osteosarcoma viral oncogene homolog -2.67215
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.62448
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.62153
AQP5 aquaporin 5 -2.4629
CDC42 cell division cycle 42 -2.3593
IST1 increased sodium tolerance 1 homolog (yeast) -2.31275
SUSD6 sushi domain containing 6 -2.26185
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -2.23985
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.21415
MSH6 mutS homolog 6 -2.20915
DLK1 delta-like 1 homolog (Drosophila) -2.1532
KRT10 keratin 10, type I -2.15308
MAGT1 magnesium transporter 1 -2.1427
UBB ubiquitin B -2.11805
PLAGL2 pleiomorphic adenoma gene-like 2 -2.10922
ZBTB38 zinc finger and BTB domain containing 38 -2.10525
ZCCHC8 zinc finger, CCHC domain containing 8 -2.09055
CSF2 colony stimulating factor 2 (granulocyte-macrophage) -2.09035
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.07145
PRDX1 peroxiredoxin 1 -2.0641
FBXL12 F-box and leucine-rich repeat protein 12 -2.059
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.05485
SPATA2 spermatogenesis associated 2 -2.03907
WDR37 WD repeat domain 37 -2.01795
ZNF443 zinc finger protein 443 -2.0117
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.00205