CRCGN011_HEPG2_24H:J09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trimethylaniline 5.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN011_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 6.15635
ZNF589 zinc finger protein 589 5.3531
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.09755
UBQLN2 ubiquilin 2 4.92645
CHMP6 charged multivesicular body protein 6 4.8268
CYCS cytochrome c, somatic 4.1131
CCL2 chemokine (C-C motif) ligand 2 4.04365
TIAM1 T-cell lymphoma invasion and metastasis 1 3.29623
RNF167 ring finger protein 167 3.23045
GPATCH8 G patch domain containing 8 3.06322
SSBP2 single-stranded DNA binding protein 2 2.76542
TEX10 testis expressed 10 2.74575
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.61363
HSPA1A heat shock 70kDa protein 1A 2.49375
DHDDS dehydrodolichyl diphosphate synthase 2.4872
BAMBI BMP and activin membrane-bound inhibitor 2.48125
SIRT3 sirtuin 3 2.41608
TUBG2 tubulin, gamma 2 2.3519
ARL17B ADP-ribosylation factor-like 17B 2.302
LYN LYN proto-oncogene, Src family tyrosine kinase 2.29078
LEP leptin 2.25265
PTPRM protein tyrosine phosphatase, receptor type, M 2.1996
SALL2 spalt-like transcription factor 2 2.13645
ZFAND1 zinc finger, AN1-type domain 1 2.11
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.0903
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.04375
ZIC1 Zic family member 1 2.00995
TMEM120B transmembrane protein 120B 2.0093

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.1329
CCNB2 cyclin B2 -4.85405
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.67375
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.44535
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.2382
LYPLA1 lysophospholipase I -3.28255
PCNA proliferating cell nuclear antigen -3.2752
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.16295
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.06388
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.8823
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.829
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.7398
DPYS dihydropyrimidinase -2.617
PLG plasminogen -2.59607
VDAC1 voltage-dependent anion channel 1 -2.5389
RFC2 replication factor C (activator 1) 2, 40kDa -2.53417
DPEP1 dipeptidase 1 (renal) -2.3813
FBXO7 F-box protein 7 -2.3776
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -2.3172
CFHR2 complement factor H-related 2 -2.31
HEATR1 HEAT repeat containing 1 -2.30893
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -2.30555
SOAT2 sterol O-acyltransferase 2 -2.2826
AADAC arylacetamide deacetylase -2.24335
HLA-DMA major histocompatibility complex, class II, DM alpha -2.2407
AQP9 aquaporin 9 -2.19525
PRRC1 proline-rich coiled-coil 1 -2.16655
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1582
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.14215
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.10955
SCCPDH saccharopine dehydrogenase (putative) -2.10635
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.0979
ANGPTL3 angiopoietin-like 3 -2.082
FLOT1 flotillin 1 -2.06628
KHK ketohexokinase (fructokinase) -2.03083
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.0073
TOM1 target of myb1 (chicken) -2.0026