CRCGN011_HEPG2_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trimethylaniline 2.69 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN011_HEPG2_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.6757
UBQLN2 ubiquilin 2 6.3191
CIAO3 cytosolic iron-sulfur assembly component 3 5.83955
MAMLD1 mastermind-like domain containing 1 5.29725
MYLK myosin light chain kinase 4.96055
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.95425
TREM1 triggering receptor expressed on myeloid cells 1 4.946
SHB Src homology 2 domain containing adaptor protein B 4.78428
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.76425
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.8749
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.76817
ADGRE5 adhesion G protein-coupled receptor E5 3.06145
JADE2 jade family PHD finger 2 2.8668
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.77445
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.7541
SSBP2 single-stranded DNA binding protein 2 2.71742
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.68395
TEX10 testis expressed 10 2.65125
NTAQ1 N-terminal glutamine amidase 1 2.41175
GPER1 G protein-coupled estrogen receptor 1 2.40578
CCDC85B coiled-coil domain containing 85B 2.2986
DENND10 DENN domain containing 10 2.20005
COQ8A coenzyme Q8A 2.1338
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.0983
APP amyloid beta (A4) precursor protein 2.08275
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.07156
UIMC1 ubiquitin interaction motif containing 1 2.06055
MPO myeloperoxidase 2.06008
BCL9 B-cell CLL/lymphoma 9 2.0406
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.03305
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.0235
SCRN1 secernin 1 2.02175
ACBD3 acyl-CoA binding domain containing 3 2.00607

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
FABP5 fatty acid binding protein 5 (psoriasis-associated) -10.0
C2CD5 C2 calcium-dependent domain containing 5 -5.5265
FASTKD5 FAST kinase domains 5 -5.3872
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.3115
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0
HMG20B high mobility group 20B -4.95302
LDHD lactate dehydrogenase D -4.89775
DNM1L dynamin 1-like -4.7399
MAP7 microtubule-associated protein 7 -4.46132
TLCD3A TLC domain containing 3A -4.4269
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.29885
GNAS GNAS complex locus -3.73091
MAPK13 mitogen-activated protein kinase 13 -3.7007
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.4173
CTNND1 catenin (cadherin-associated protein), delta 1 -3.12043
IFRD2 interferon-related developmental regulator 2 -2.9642
GDF15 growth differentiation factor 15 -2.91295
ZMIZ1 zinc finger, MIZ-type containing 1 -2.8409
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.80362
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.7987
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.7559
HLA-DMA major histocompatibility complex, class II, DM alpha -2.6461
RAD51C RAD51 paralog C -2.40368
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.3646
HEATR1 HEAT repeat containing 1 -2.33792
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.3341
MEOX2 mesenchyme homeobox 2 -2.3258
CXCL14 chemokine (C-X-C motif) ligand 14 -2.27765
GRWD1 glutamate-rich WD repeat containing 1 -2.26375
SPAG4 sperm associated antigen 4 -2.2132
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.1865
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.16385
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.16005
ETNK1 ethanolamine kinase 1 -2.1515
SESN1 sestrin 1 -2.1288
STK25 serine/threonine kinase 25 -2.12525
BTG2 BTG family, member 2 -2.1054
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.1002
RCAN3 RCAN family member 3 -2.0991
CH25H cholesterol 25-hydroxylase -2.09235
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.03015
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.02772
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.02505
GOLGA8N golgin A8 family, member N -2.0196
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.01805