CRCGN011_HEPG2_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trimethylaniline 1.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.7219
SHB Src homology 2 domain containing adaptor protein B 5.00877
BACE2 beta-site APP-cleaving enzyme 2 4.98455
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.87295
E2F2 E2F transcription factor 2 4.7896
PPARG peroxisome proliferator-activated receptor gamma 4.72185
RPP38 ribonuclease P/MRP 38kDa subunit 4.29865
PLSCR1 phospholipid scramblase 1 4.07795
GPER1 G protein-coupled estrogen receptor 1 3.72778
FZD7 frizzled class receptor 7 3.49482
TLR4 toll-like receptor 4 3.29065
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.15315
BAMBI BMP and activin membrane-bound inhibitor 3.129
JADE2 jade family PHD finger 2 2.82797
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.8036
CGRRF1 cell growth regulator with ring finger domain 1 2.78595
ZBTB35 zinc finger and BTB domain containing 35 2.6782
CRELD2 cysteine-rich with EGF-like domains 2 2.5795
H2BC12 H2B clustered histone 12 2.53732
SSBP2 single-stranded DNA binding protein 2 2.52942
PLSCR3 phospholipid scramblase 3 2.44228
HEBP1 heme binding protein 1 2.4197
COQ8A coenzyme Q8A 2.3892
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.37775
TEX10 testis expressed 10 2.3288
RNFT1-DT RNFT1 divergent transcript 2.30665
EVL Enah/Vasp-like 2.2924
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.2799
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.1478
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.11945
ANO10 anoctamin 10 2.08525
SURF2 surfeit 2 2.0509
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.0314
SPATA7 spermatogenesis associated 7 2.01115

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.33292
TM9SF3 transmembrane 9 superfamily member 3 -5.2999
LDHD lactate dehydrogenase D -5.03885
CCNB1 cyclin B1 -5.02415
ADI1 acireductone dioxygenase 1 -4.9308
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.8757
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.8401
COG2 component of oligomeric golgi complex 2 -4.73425
CHMP4B charged multivesicular body protein 4B -4.28915
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.25525
CDC25B cell division cycle 25B -3.9929
TLCD3A TLC domain containing 3A -3.60665
ACAA1 acetyl-CoA acyltransferase 1 -3.3863
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.094
IFRD2 interferon-related developmental regulator 2 -3.0496
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.76815
NSF N-ethylmaleimide-sensitive factor -2.54775
VDAC1 voltage-dependent anion channel 1 -2.47642
OXA1L oxidase (cytochrome c) assembly 1-like -2.4343
HEATR1 HEAT repeat containing 1 -2.29787
ZNF76 zinc finger protein 76 -2.2682
TRAP1 TNF receptor-associated protein 1 -2.115
CTSK cathepsin K -2.0448
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.03905
EIF5 eukaryotic translation initiation factor 5 -2.00371
MXRA5 matrix-remodelling associated 5 -2.0006