| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4,5-trimethylaniline 0.67 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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88 genes differentially expressed following the CRCGN011_HEPG2_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STIMATE | STIM activating enhancer | 10.0 |
| UBQLN2 | ubiquilin 2 | 10.0 |
| SQOR | sulfide quinone oxidoreductase | 5.53565 |
| PLS1 | plastin 1 | 4.8683 |
| HOXA10 | homeobox A10 | 4.79513 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.7746 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 4.62315 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.49755 |
| NMU | neuromedin U | 4.4674 |
| CCDC85B | coiled-coil domain containing 85B | 4.42215 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.92495 |
| CYCS | cytochrome c, somatic | 3.8633 |
| COQ8A | coenzyme Q8A | 3.78115 |
| FZD7 | frizzled class receptor 7 | 3.6037 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.35465 |
| VGLL4 | vestigial-like family member 4 | 3.3468 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.19948 |
| PIH1D1 | PIH1 domain containing 1 | 3.01265 |
| H2BC12 | H2B clustered histone 12 | 2.93025 |
| PLSCR3 | phospholipid scramblase 3 | 2.74342 |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 2.73935 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.59995 |
| RAI14 | retinoic acid induced 14 | 2.5822 |
| DENND2B | DENN domain containing 2B | 2.44635 |
| NEK4 | NIMA-related kinase 4 | 2.3872 |
| MAT2B | methionine adenosyltransferase II, beta | 2.34415 |
| SIRT3 | sirtuin 3 | 2.31743 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.24522 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 2.22115 |
| LTA4H | leukotriene A4 hydrolase | 2.2087 |
| KCNG2 | potassium channel, voltage gated modifier subfamily G, member 2 | 2.1911 |
| LIFR | leukemia inhibitory factor receptor alpha | 2.17505 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 | 2.11005 |
| CST1 | cystatin SN | 2.0937 |
| GOLT1B | golgi transport 1B | 2.07035 |
| APEX2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | 2.0663 |
| HAMP | hepcidin antimicrobial peptide | 2.0615 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 2.04095 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 2.03778 |
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | 2.03495 |
| KRT15 | keratin 15, type I | 2.01295 |
| KRT13 | keratin 13, type I | 2.01275 |
| SYNDIG1 | synapse differentiation inducing 1 | 2.0077 |
| TEX10 | testis expressed 10 | 2.00275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -6.3668 |
| TLCD3A | TLC domain containing 3A | -5.84175 |
| VAT1 | vesicle amine transport 1 | -5.54385 |
| CHMP4B | charged multivesicular body protein 4B | -5.19605 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.1024 |
| TRIB3 | tribbles pseudokinase 3 | -5.08165 |
| GDF15 | growth differentiation factor 15 | -5.0 |
| PCNA | proliferating cell nuclear antigen | -4.82295 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -4.57205 |
| MAP7 | microtubule-associated protein 7 | -4.49102 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -4.39065 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.0288 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.79277 |
| CDC25B | cell division cycle 25B | -3.6624 |
| ZW10 | zw10 kinetochore protein | -3.4821 |
| GNAS | GNAS complex locus | -3.03226 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.97755 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.8885 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.7636 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.70668 |
| TYRP1 | tyrosinase-related protein 1 | -2.6812 |
| RBM15B | RNA binding motif protein 15B | -2.5853 |
| MTO1 | mitochondrial tRNA translation optimization 1 | -2.47582 |
| KRT2 | keratin 2, type II | -2.453 |
| GLOD4 | glyoxalase domain containing 4 | -2.3511 |
| ANKRD10 | ankyrin repeat domain 10 | -2.3192 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -2.25335 |
| ACVR2A | activin A receptor, type IIA | -2.20905 |
| CD58 | CD58 molecule | -2.20535 |
| CD207 | CD207 molecule, langerin | -2.20085 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | -2.1952 |
| LORICRIN | loricrin cornified envelope precursor protein | -2.17335 |
| PNOC | prepronociceptin | -2.1733 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -2.15545 |
| ACLY | ATP citrate lyase | -2.15283 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -2.14695 |
| ZBTB24 | zinc finger and BTB domain containing 24 | -2.14015 |
| WASHC5 | WASH complex subunit 5 | -2.14005 |
| SOCS4 | suppressor of cytokine signaling 4 | -2.04155 |
| CHEK1 | checkpoint kinase 1 | -2.03932 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -2.02565 |
| CAPN15 | calpain 15 | -2.0235 |
| KRT1 | keratin 1, type II | -2.0117 |
