CRCGN011_HEPG2_24H:J16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

113 genes differentially expressed following the CRCGN011_HEPG2_24H:J16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 9.5005
LCN2 lipocalin 2 7.414
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.47615
CIAO3 cytosolic iron-sulfur assembly component 3 5.1372
NOTCH1 notch 1 5.1156
EPHB2 EPH receptor B2 5.05644
CXCL2 chemokine (C-X-C motif) ligand 2 4.99845
E2F2 E2F transcription factor 2 4.89815
PPARG peroxisome proliferator-activated receptor gamma 4.7133
EPN2 epsin 2 4.6981
PNKP polynucleotide kinase 3'-phosphatase 4.6418
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.5599
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.5311
SNAP25 synaptosomal-associated protein, 25kDa 4.1249
ABHD6 abhydrolase domain containing 6 3.98843
RNF167 ring finger protein 167 3.6155
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.61385
CCL2 chemokine (C-C motif) ligand 2 3.45285
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.43
GADD45A growth arrest and DNA-damage-inducible, alpha 3.03415
ATOH1 atonal homolog 1 (Drosophila) 2.8277
NCF4 neutrophil cytosolic factor 4, 40kDa 2.69688
DTX2 deltex 2, E3 ubiquitin ligase 2.69535
JADE2 jade family PHD finger 2 2.68718
CALCB calcitonin-related polypeptide beta 2.6691
SSBP2 single-stranded DNA binding protein 2 2.60065
TUBA4B tubulin, alpha 4b 2.5738
FOXD2 forkhead box D2 2.55465
EXTL1 exostosin-like glycosyltransferase 1 2.50725
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.4829
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.47667
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.45213
TBXA2R thromboxane A2 receptor 2.44564
DOK4 docking protein 4 2.41903
CDX1 caudal type homeobox 1 2.4068
CETN3 centrin, EF-hand protein, 3 2.36315
MYBPC3 myosin binding protein C, cardiac 2.34795
NANOS2 nanos homolog 2 (Drosophila) 2.32715
CABP2 calcium binding protein 2 2.31895
CCNF cyclin F 2.3084
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.2526
FOXB1 forkhead box B1 2.22425
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.21035
BCL9 B-cell CLL/lymphoma 9 2.21025
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.207
SFRP5 secreted frizzled-related protein 5 2.17425
BDKRB1 bradykinin receptor B1 2.1741
NEUROG3 neurogenin 3 2.164
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.15575
GEMIN7 gem (nuclear organelle) associated protein 7 2.1554
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.1554
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.1484
GPR68 G protein-coupled receptor 68 2.11955
TULP1 tubby like protein 1 2.11835
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.11645
KLK15 kallikrein-related peptidase 15 2.11265
H2BC9 H2B clustered histone 9 2.11045
ERMAP erythroblast membrane-associated protein (Scianna blood group) 2.1067
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.10235
IRGC immunity-related GTPase family, cinema 2.0968
RBMX RNA binding motif protein, X-linked 2.0818
PMCH pro-melanin-concentrating hormone 2.0787
TREH trehalase (brush-border membrane glycoprotein) 2.0701
ETV2 ets variant 2 2.0608
POMC proopiomelanocortin 2.0583
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.0568
FOXO3 forkhead box O3 2.05354
TES testin LIM domain protein 2.05215
HOXA6 homeobox A6 2.051
DEFA6 defensin, alpha 6, Paneth cell-specific 2.03395
ALLC allantoicase 2.03
B9D1 B9 protein domain 1 2.01778
AVEN apoptosis, caspase activation inhibitor 2.01695
TAC4 tachykinin 4 (hemokinin) 2.0145
EDN1 endothelin 1 2.0118
DNAI2 dynein, axonemal, intermediate chain 2 2.0076
CNTFR ciliary neurotrophic factor receptor 2.00355
GSTM2 glutathione S-transferase mu 2 (muscle) 2.0022

decreased expression

Symbol Name Standardized Value
AARS1 alanyl-tRNA synthetase 1 -5.33075
SCAND1 SCAN domain containing 1 -5.31775
ACAA1 acetyl-CoA acyltransferase 1 -5.04497
KDM3A lysine (K)-specific demethylase 3A -4.9228
PCNA proliferating cell nuclear antigen -4.82295
LDHD lactate dehydrogenase D -4.78685
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.71785
CCNB1 cyclin B1 -4.6367
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.51435
ARID5B AT rich interactive domain 5B (MRF1-like) -4.36755
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.08795
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.80195
ADI1 acireductone dioxygenase 1 -3.4435
NRIP1 nuclear receptor interacting protein 1 -3.19958
GNAS GNAS complex locus -2.98774
SLC35F2 solute carrier family 35, member F2 -2.96235
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.96015
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.9163
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.83272
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.81964
NPDC1 neural proliferation, differentiation and control, 1 -2.68965
PRPF4 pre-mRNA processing factor 4 -2.37993
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.3723
MYBPC1 myosin binding protein C, slow type -2.3328
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.3063
MARS1 methionyl-tRNA synthetase 1 -2.22822
CST3 cystatin C -2.19985
STXBP1 syntaxin binding protein 1 -2.1617
CEMIP2 cell migration inducing hyaluronidase 2 -2.1397
IPO13 importin 13 -2.11485
ITGB1BP1 integrin beta 1 binding protein 1 -2.10383
APOH apolipoprotein H (beta-2-glycoprotein I) -2.0683
CTSV cathepsin V -2.05745
FBXL12 F-box and leucine-rich repeat protein 12 -2.0505
FOS FBJ murine osteosarcoma viral oncogene homolog -2.0479