CRCGN011_HEPG2_24H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

167 genes differentially expressed following the CRCGN011_HEPG2_24H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 9.49145
UBQLN2 ubiquilin 2 5.18915
ATP11B ATPase, class VI, type 11B 5.06835
CXCL2 chemokine (C-X-C motif) ligand 2 5.02055
NMU neuromedin U 4.77395
NOTCH1 notch 1 4.5294
CHN1 chimerin 1 4.29945
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.17445
PRKCQ protein kinase C, theta 3.7202
SNAP25 synaptosomal-associated protein, 25kDa 3.617
PLSCR3 phospholipid scramblase 3 3.55452
GSTZ1 glutathione S-transferase zeta 1 3.52055
COQ8A coenzyme Q8A 3.48895
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.99415
CCDC59 coiled-coil domain containing 59 2.9539
AMDHD2 amidohydrolase domain containing 2 2.6668
CCNF cyclin F 2.3866
SNX6 sorting nexin 6 2.2861
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.27165
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.24875
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.22015
RAB23 RAB23, member RAS oncogene family 2.1683
MACROH2A2 macroH2A.2 histone 2.15995
CYCS cytochrome c, somatic 2.1447
POGLUT2 protein O-glucosyltransferase 2 2.14275
LOC112694756 uncharaterized LOC112694756 2.08345
SSR4 signal sequence receptor, delta 2.08275
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.08255
GPX7 glutathione peroxidase 7 2.0793
CCNE2 cyclin E2 2.0718
MYL11 myosin light chain 11 2.06805
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.06485
BIRC2 baculoviral IAP repeat containing 2 2.0373
PYCR1 pyrroline-5-carboxylate reductase 1 2.02955
ALDOC aldolase C, fructose-bisphosphate 2.01455
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.01318
DBF4 DBF4 zinc finger 2.01105
IFT20 intraflagellar transport 20 2.0092

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.669
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.2789
PUF60 poly-U binding splicing factor 60KDa -5.10865
ZNF586 zinc finger protein 586 -4.94455
LDHD lactate dehydrogenase D -4.8253
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.78075
MAP7 microtubule-associated protein 7 -4.76185
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.61725
FGFR4 fibroblast growth factor receptor 4 -3.66488
CCNB2 cyclin B2 -3.40085
PCNA proliferating cell nuclear antigen -3.317
OXA1L oxidase (cytochrome c) assembly 1-like -3.23195
GSTA3 glutathione S-transferase alpha 3 -3.11965
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.99363
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -2.9864
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9602
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.8235
DRC9 dynein regulatory complex subunit 9 -2.82175
PODNL1 podocan-like 1 -2.7904
CLDN15 claudin 15 -2.7429
DNAI4 dynein axonemal intermediate chain 4 -2.736
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.69697
KLHL35 kelch-like family member 35 -2.6786
CLXN calaxin -2.66255
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.64705
ADPRH ADP-ribosylarginine hydrolase -2.60325
ZNF134 zinc finger protein 134 -2.5874
DNAH3 dynein, axonemal, heavy chain 3 -2.5461
AMHR2 anti-Mullerian hormone receptor, type II -2.51295
DNAH7 dynein, axonemal, heavy chain 7 -2.4702
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.46365
BTN1A1 butyrophilin, subfamily 1, member A1 -2.4522
OR2C1 olfactory receptor, family 2, subfamily C, member 1 -2.4514
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.43125
SNX11 sorting nexin 11 -2.41275
CCDC33 coiled-coil domain containing 33 -2.40845
SIRT6 sirtuin 6 -2.39775
ANKRD37 ankyrin repeat domain 37 -2.37055
ZMYND10 zinc finger, MYND-type containing 10 -2.36855
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.36735
SCRIB scribbled planar cell polarity protein -2.36525
ANXA13 annexin A13 -2.3584
ZDHHC13 zinc finger, DHHC-type containing 13 -2.3424
ZNF154 zinc finger protein 154 -2.33655
DDB1 damage-specific DNA binding protein 1, 127kDa -2.33585
PRAMEF26 PRAME family member 26 -2.33215
DRC3 dynein regulatory complex subunit 3 -2.3304
SCGB1D2 secretoglobin, family 1D, member 2 -2.32295
ALPK1 alpha-kinase 1 -2.31455
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.30955
SLC35F2 solute carrier family 35, member F2 -2.3092
IHH indian hedgehog -2.3052
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.30505
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 -2.2966
ZBBX zinc finger, B-box domain containing -2.2735
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.26805
GDF15 growth differentiation factor 15 -2.26445
VPS35L VPS35 endosomal protein sorting factor like -2.26195
GFRA3 GDNF family receptor alpha 3 -2.249
TRHR thyrotropin-releasing hormone receptor -2.24285
CRIPTO3 cripto, EGF-CFC family member 3 -2.24125
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.23878
DBF4B DBF4 zinc finger B -2.22965
ITGB1BP1 integrin beta 1 binding protein 1 -2.22233
GPATCH3 G patch domain containing 3 -2.2201
LGALS4 lectin, galactoside-binding, soluble, 4 -2.2192
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -2.20755
DNAI1 dynein, axonemal, intermediate chain 1 -2.2044
CFAP74 cilia and flagella associated protein 74 -2.19418
KRT33B keratin 33B, type I -2.192
CENPE centromere protein E, 312kDa -2.189
ZNF34 zinc finger protein 34 -2.1828
TEC tec protein tyrosine kinase -2.1752
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.16875
OR7A17 olfactory receptor, family 7, subfamily A, member 17 -2.168
FGD2 FYVE, RhoGEF and PH domain containing 2 -2.1593
MC4R melanocortin 4 receptor -2.15635
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -2.151
KLHL18 kelch-like family member 18 -2.1499
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -2.14855
KLHDC8A kelch domain containing 8A -2.1407
HYDIN HYDIN, axonemal central pair apparatus protein -2.1381
ECEL1 endothelin converting enzyme-like 1 -2.12825
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 -2.12663
DDHD2 DDHD domain containing 2 -2.1233
TAOK1 TAO kinase 1 -2.11845
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.1147
ACAA1 acetyl-CoA acyltransferase 1 -2.10633
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.1051
SPAG4 sperm associated antigen 4 -2.1047
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.0965
KRT38 keratin 38, type I -2.09495
HGH1 HGH1 homolog (S. cerevisiae) -2.09312
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.0901
TACR3 tachykinin receptor 3 -2.08775
FOXJ1 forkhead box J1 -2.08655
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.0842
DOCK2 dedicator of cytokinesis 2 -2.0831
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.07915
IRF2 interferon regulatory factor 2 -2.0746
MBTD1 mbt domain containing 1 -2.07165
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -2.06945
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.06925
ARMH3 armadillo like helical domain containing 3 -2.0674
DLEC1 deleted in lung and esophageal cancer 1 -2.06533
GPR75 G protein-coupled receptor 75 -2.06115
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.059
CFAP45 cilia and flagella associated protein 45 -2.0518
MUC2 mucin 2, oligomeric mucus/gel-forming -2.0494
CABP5 calcium binding protein 5 -2.0459
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.04558
EFHD2 EF-hand domain family, member D2 -2.0396
GAR1 GAR1 ribonucleoprotein -2.0368
REEP4 receptor accessory protein 4 -2.0331
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -2.0317
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.02835
OVOL3 ovo-like zinc finger 3 -2.02755
TRIM68 tripartite motif containing 68 -2.02755
ZNF548 zinc finger protein 548 -2.0263
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.0259
CREBL2 cAMP responsive element binding protein-like 2 -2.01417
CCR8 chemokine (C-C motif) receptor 8 -2.01095
CLEC1A C-type lectin domain family 1, member A -2.0107
HAUS2 HAUS augmin-like complex, subunit 2 -2.01005
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -2.0085
ADAP2 ArfGAP with dual PH domains 2 -2.0078
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.00745
ZNF611 zinc finger protein 611 -2.0