| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-(9h-fluoren-2-yl)-2,2,2-trifluoroacetamide 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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91 genes differentially expressed following the CRCGN011_HEPG2_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 6.4633 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 6.31615 |
| JADE2 | jade family PHD finger 2 | 5.5885 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 5.3434 |
| E2F2 | E2F transcription factor 2 | 5.2356 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.92885 |
| STK10 | serine/threonine kinase 10 | 4.64325 |
| NOTCH1 | notch 1 | 4.5692 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.50145 |
| CHMP6 | charged multivesicular body protein 6 | 4.4602 |
| FZD1 | frizzled class receptor 1 | 4.31452 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.04645 |
| ABHD6 | abhydrolase domain containing 6 | 3.93748 |
| MEF2C | myocyte enhancer factor 2C | 3.79128 |
| TRAK2 | trafficking protein, kinesin binding 2 | 3.53305 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 3.0843 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.04255 |
| CDC45 | cell division cycle 45 | 3.031 |
| RXYLT1 | ribitol xylosyltransferase 1 | 3.02833 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.93545 |
| CCNF | cyclin F | 2.89457 |
| SNX7 | sorting nexin 7 | 2.7088 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.48745 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | 2.4675 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.424 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.37565 |
| ZNF589 | zinc finger protein 589 | 2.3741 |
| FBXO11 | F-box protein 11 | 2.3335 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 2.3061 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 2.29725 |
| CHAD | chondroadherin | 2.25445 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.2163 |
| TRAM2 | translocation associated membrane protein 2 | 2.18837 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | 2.17978 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.1702 |
| PLSCR4 | phospholipid scramblase 4 | 2.15705 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 2.15702 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.14688 |
| CTSL | cathepsin L | 2.12935 |
| NNT | nicotinamide nucleotide transhydrogenase | 2.1118 |
| IL17B | interleukin 17B | 2.09535 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.08955 |
| EPHA3 | EPH receptor A3 | 2.07227 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 2.04177 |
| HMOX1 | heme oxygenase 1 | 2.0413 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 2.0314 |
| PARP1 | poly (ADP-ribose) polymerase 1 | 2.01145 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MRPS2 | mitochondrial ribosomal protein S2 | -5.07765 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.98755 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.89165 |
| PCNA | proliferating cell nuclear antigen | -4.82295 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.66275 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -4.50555 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -4.25717 |
| ZW10 | zw10 kinetochore protein | -4.01435 |
| YME1L1 | YME1-like 1 ATPase | -4.00092 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.8548 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -3.8048 |
| SCAND1 | SCAN domain containing 1 | -3.7105 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.66055 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.6592 |
| GNAS | GNAS complex locus | -3.47865 |
| SLC35F2 | solute carrier family 35, member F2 | -3.47245 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.9781 |
| VDAC1 | voltage-dependent anion channel 1 | -2.9376 |
| RPS5 | ribosomal protein S5 | -2.8382 |
| CAB39 | calcium binding protein 39 | -2.75315 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -2.73465 |
| CCNB2 | cyclin B2 | -2.624 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.52562 |
| XPO7 | exportin 7 | -2.4795 |
| TGFB3 | transforming growth factor, beta 3 | -2.4153 |
| ZNF12 | zinc finger protein 12 | -2.41075 |
| GHR | growth hormone receptor | -2.33825 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.33425 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.31965 |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | -2.3046 |
| NVL | nuclear VCP-like | -2.2484 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.2299 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -2.20015 |
| KIF14 | kinesin family member 14 | -2.1895 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.11585 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -2.11305 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -2.10795 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -2.0775 |
| TUBB6 | tubulin, beta 6 class V | -2.05625 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -2.04338 |
| ADNP2 | ADNP homeobox 2 | -2.0309 |
| OR51E2 | olfactory receptor, family 51, subfamily E, member 2 | -2.02495 |
| TRAPPC6A | trafficking protein particle complex 6A | -2.0095 |
| CHKB | choline kinase beta | -2.00155 |
