| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-(9h-fluoren-2-yl)-2,2,2-trifluoroacetamide 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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105 genes differentially expressed following the CRCGN011_HEPG2_24H:J21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CBR3 | carbonyl reductase 3 | 7.4675 |
| SQOR | sulfide quinone oxidoreductase | 5.25585 |
| CSK | c-src tyrosine kinase | 5.21075 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.09765 |
| LCN2 | lipocalin 2 | 5.0 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.9843 |
| AMDHD2 | amidohydrolase domain containing 2 | 4.9695 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.8414 |
| MYLK | myosin light chain kinase | 4.8039 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.7925 |
| CHMP6 | charged multivesicular body protein 6 | 4.51085 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.4253 |
| STIMATE | STIM activating enhancer | 3.8601 |
| PRR15L | proline rich 15-like | 3.75365 |
| GATA3 | GATA binding protein 3 | 3.7184 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.6457 |
| HYOU1 | hypoxia up-regulated 1 | 3.2772 |
| TLR4 | toll-like receptor 4 | 3.13755 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 3.12427 |
| WDR6 | WD repeat domain 6 | 2.8967 |
| ABHD6 | abhydrolase domain containing 6 | 2.88685 |
| NUP133 | nucleoporin 133kDa | 2.86875 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.77025 |
| CMTR1 | cap methyltransferase 1 | 2.7144 |
| JADE2 | jade family PHD finger 2 | 2.66205 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | 2.65665 |
| COMMD3-BMI1 | COMMD3-BMI1 readthrough | 2.54645 |
| FZD7 | frizzled class receptor 7 | 2.45648 |
| MLST8 | MTOR associated protein, LST8 homolog (S. cerevisiae) | 2.42185 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 2.22405 |
| SPAG4 | sperm associated antigen 4 | 2.2174 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2.20215 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 2.20055 |
| HDAC1 | histone deacetylase 1 | 2.1923 |
| PHF11 | PHD finger protein 11 | 2.18335 |
| NMU | neuromedin U | 2.17685 |
| YTHDC1 | YTH domain containing 1 | 2.17345 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 2.17135 |
| GPATCH8 | G patch domain containing 8 | 2.16792 |
| FRZB | frizzled-related protein | 2.167 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.16258 |
| COPS4 | COP9 signalosome subunit 4 | 2.13805 |
| ZNF26 | zinc finger protein 26 | 2.11395 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 2.112 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.10945 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 2.0963 |
| FZD6 | frizzled class receptor 6 | 2.08975 |
| RAB3D | RAB3D, member RAS oncogene family | 2.074 |
| METTL22 | methyltransferase like 22 | 2.07055 |
| LOC122526780 | uncharacterized LOC122526780 | 2.05955 |
| CDC23 | cell division cycle 23 | 2.05095 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | 2.0421 |
| BCKDK | branched chain ketoacid dehydrogenase kinase | 2.042 |
| PPIP5K1 | diphosphoinositol pentakisphosphate kinase 1 | 2.038 |
| PHIP | pleckstrin homology domain interacting protein | 2.02925 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 2.0191 |
| MEST | mesoderm specific transcript | 2.01875 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -8.81755 |
| PCNA | proliferating cell nuclear antigen | -8.51775 |
| THAP11 | THAP domain containing 11 | -5.015 |
| ADI1 | acireductone dioxygenase 1 | -4.78895 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.76335 |
| CCNB2 | cyclin B2 | -4.70695 |
| UGDH | UDP-glucose 6-dehydrogenase | -4.66275 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -4.60625 |
| CDC20 | cell division cycle 20 | -4.2518 |
| NGRN | neugrin, neurite outgrowth associated | -4.116 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -4.06402 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.78513 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -3.7022 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.40465 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | -3.24197 |
| TLCD3A | TLC domain containing 3A | -3.0511 |
| RBM34 | RNA binding motif protein 34 | -2.96962 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.86757 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.8664 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.852 |
| DCK | deoxycytidine kinase | -2.8356 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.8274 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.78439 |
| S100A4 | S100 calcium binding protein A4 | -2.6877 |
| TFB2M | transcription factor B2, mitochondrial | -2.59835 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.4812 |
| NOP56 | NOP56 ribonucleoprotein | -2.35975 |
| INCENP | inner centromere protein antigens 135/155kDa | -2.35545 |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | -2.32285 |
| EXOSC5 | exosome component 5 | -2.2801 |
| BFAR | bifunctional apoptosis regulator | -2.23695 |
| TWNK | twinkle mtDNA helicase | -2.20725 |
| RNPEP | arginyl aminopeptidase (aminopeptidase B) | -2.17755 |
| TAF5L | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | -2.1759 |
| EN2 | engrailed homeobox 2 | -2.1411 |
| KDM8 | lysine (K)-specific demethylase 8 | -2.1221 |
| ZC4H2 | zinc finger, C4H2 domain containing | -2.12185 |
| ZW10 | zw10 kinetochore protein | -2.10995 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) | -2.1098 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.10105 |
| CD177 | CD177 molecule | -2.1005 |
| ZNF281 | zinc finger protein 281 | -2.06645 |
| NCF4 | neutrophil cytosolic factor 4, 40kDa | -2.0607 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | -2.05085 |
| SREK1IP1 | SREK1-interacting protein 1 | -2.03605 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -2.02625 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -2.013 |
| TNFAIP8L2-SCNM1 | TNFAIP8L2-SCNM1 readthrough | -2.00025 |
