CRCGN011_HEPG2_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9h-fluoren-2-yl)-2,2,2-trifluoroacetamide 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.30275
STAP2 signal transducing adaptor family member 2 5.2361
GSTZ1 glutathione S-transferase zeta 1 5.0867
JADE2 jade family PHD finger 2 5.04343
PPARG peroxisome proliferator-activated receptor gamma 4.7169
CSK c-src tyrosine kinase 4.66275
CHMP6 charged multivesicular body protein 6 4.56125
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.2594
CXCL2 chemokine (C-X-C motif) ligand 2 4.0398
ABHD6 abhydrolase domain containing 6 3.92893
PEX11A peroxisomal biogenesis factor 11 alpha 3.6435
MAP7 microtubule-associated protein 7 3.43262
ABHD4 abhydrolase domain containing 4 3.31745
GATA3 GATA binding protein 3 3.1961
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.14505
RXYLT1 ribitol xylosyltransferase 1 3.1034
LOC122526780 uncharacterized LOC122526780 2.92425
SSBP2 single-stranded DNA binding protein 2 2.71657
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7079
HLA-DRA major histocompatibility complex, class II, DR alpha 2.59812
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.4577
MAST2 microtubule associated serine/threonine kinase 2 2.40977
PRR15L proline rich 15-like 2.3754
CHN1 chimerin 1 2.3441
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.3269
SMIM40 small integral membrane protein 40 2.2109
GARRE1 granule associated Rac and RHOG effector 1 2.1964
WASF3 WAS protein family, member 3 2.17395
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.15045
WTAP Wilms tumor 1 associated protein 2.14523
COPS7A COP9 signalosome subunit 7A 2.1367
GRWD1 glutamate-rich WD repeat containing 1 2.0795
CCNF cyclin F 2.0355
ARID4B AT rich interactive domain 4B (RBP1-like) 2.02765
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.0176
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.0142

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.35735
ARID5B AT rich interactive domain 5B (MRF1-like) -5.3349
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.32785
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8523
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.73215
GDF15 growth differentiation factor 15 -4.50475
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.50315
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.4849
TM9SF3 transmembrane 9 superfamily member 3 -4.4485
NGRN neugrin, neurite outgrowth associated -4.36035
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -4.11305
OXA1L oxidase (cytochrome c) assembly 1-like -3.69555
GNAS GNAS complex locus -3.57799
CCNB2 cyclin B2 -3.08215
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.94492
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.61425
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.5059
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.27327
GLOD4 glyoxalase domain containing 4 -2.21305
RASL11B RAS-like, family 11, member B -2.16695
KLC3 kinesin light chain 3 -2.16585
SMAD7 SMAD family member 7 -2.1189
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.0901