CRCGN011_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9h-fluoren-2-yl)-2,2,2-trifluoroacetamide 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.57145
PPARG peroxisome proliferator-activated receptor gamma 5.0466
NMU neuromedin U 4.83545
AMDHD2 amidohydrolase domain containing 2 4.77515
MAP7 microtubule-associated protein 7 3.63682
TIAM1 T-cell lymphoma invasion and metastasis 1 3.5593
CYCS cytochrome c, somatic 2.9641
ZNF589 zinc finger protein 589 2.87212
SSBP2 single-stranded DNA binding protein 2 2.67737
BAMBI BMP and activin membrane-bound inhibitor 2.6356
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.4666
MIS18A MIS18 kinetochore protein A 2.32875
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.32265
TFRC transferrin receptor 2.31827
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.28495
DOLPP1 dolichyldiphosphatase 1 2.25915
RALGDS ral guanine nucleotide dissociation stimulator 2.15313
UGDH UDP-glucose 6-dehydrogenase 2.0553
FASTKD5 FAST kinase domains 5 2.03655
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.03525
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.0022

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.558
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.2287
LDHD lactate dehydrogenase D -5.07605
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.82435
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.7446
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.61595
HMG20B high mobility group 20B -4.4384
TRAP1 TNF receptor-associated protein 1 -4.1603
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.71737
VDAC1 voltage-dependent anion channel 1 -3.6545
IPO13 importin 13 -3.4268
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.2605
GNAS GNAS complex locus -3.22454
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.0377
HEATR1 HEAT repeat containing 1 -3.0141
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.98295
CCNB2 cyclin B2 -2.88325
SESN1 sestrin 1 -2.8661
SNX11 sorting nexin 11 -2.7864
GDF15 growth differentiation factor 15 -2.59865
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.56505
ACADVL acyl-CoA dehydrogenase, very long chain -2.5346
ITGB1BP1 integrin beta 1 binding protein 1 -2.52855
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.49453
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.3577
SLC35F2 solute carrier family 35, member F2 -2.3101
TLCD3A TLC domain containing 3A -2.28505
MAPK13 mitogen-activated protein kinase 13 -2.25522
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.21975
RPAP2 RNA polymerase II associated protein 2 -2.1949
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.1697
IL7R interleukin 7 receptor -2.12005
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.10665
SPDL1 spindle apparatus coiled-coil protein 1 -2.0925
ZNF76 zinc finger protein 76 -2.04555
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.04015
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.03175
RIPOR2 RHO family interacting cell polarization regulator 2 -2.02378