CRCGN011_HEPG2_24H:K02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-(p-chlorophenyl)-1,1-di?methyl?urea 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

334 genes differentially expressed following the CRCGN011_HEPG2_24H:K02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.78747
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 6.1259
KIFBP kinesin family binding protein 5.4382
GPATCH8 G patch domain containing 8 5.4217
THAP11 THAP domain containing 11 5.3187
FASTKD5 FAST kinase domains 5 5.2225
CGRRF1 cell growth regulator with ring finger domain 1 5.026
PLEKHJ1 pleckstrin homology domain containing, family J member 1 4.656
EVL Enah/Vasp-like 4.4891
EPHA3 EPH receptor A3 4.40447
CISD1 CDGSH iron sulfur domain 1 4.0851
CEMIP2 cell migration inducing hyaluronidase 2 3.5647
HMGA2 high mobility group AT-hook 2 3.5157
PGAM4 phosphoglycerate mutase family member 4 3.4222
HMOX1 heme oxygenase 1 3.3564
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.3005
PTTG1IP pituitary tumor-transforming 1 interacting protein 3.2862
ENOPH1 enolase-phosphatase 1 3.2844
TEX10 testis expressed 10 3.2479
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.1935
RSU1 Ras suppressor protein 1 3.1426
PLS1 plastin 1 3.0967
PCCB propionyl CoA carboxylase, beta polypeptide 3.0508
BAD BCL2-associated agonist of cell death 3.0171
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.9594
CTSL cathepsin L 2.9484
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.94007
GLRX glutaredoxin (thioltransferase) 2.92685
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.8794
RCOR1 REST corepressor 1 2.861
MEIS1 Meis homeobox 1 2.8306
SYNGAP1 synaptic Ras GTPase activating protein 1 2.73875
DSG2 desmoglein 2 2.7328
H2AZ1 H2A.Z variant histone 1 2.7026
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.7012
DIPK1A divergent protein kinase domain 1A 2.65845
MTX2 metaxin 2 2.6487
PSIP1 PC4 and SFRS1 interacting protein 1 2.63397
DERA deoxyribose-phosphate aldolase (putative) 2.6256
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.6005
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.5898
BID BH3 interacting domain death agonist 2.5759
WDR37 WD repeat domain 37 2.5695
TSPAN6 tetraspanin 6 2.55785
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.5522
NNT nicotinamide nucleotide transhydrogenase 2.5495
RRAGA Ras-related GTP binding A 2.4912
MTCH1 mitochondrial carrier 1 2.4708
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.4638
CDC23 cell division cycle 23 2.4551
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.427
MFAP1 microfibrillar-associated protein 1 2.4208
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.4149
SLC35F5 solute carrier family 35, member F5 2.4081
TFG TRK-fused gene 2.402
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.4013
GAS2 growth arrest-specific 2 2.3988
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.3973
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.3958
FOXN3 forkhead box N3 2.3927
TCF12 transcription factor 12 2.3896
MGST2 microsomal glutathione S-transferase 2 2.3722
CERS1 ceramide synthase 1 2.3648
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.3604
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.3503
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.349
MDH1 malate dehydrogenase 1, NAD (soluble) 2.345
RANBP9 RAN binding protein 9 2.3417
DYNLL1 dynein, light chain, LC8-type 1 2.3394
EMC7 ER membrane protein complex subunit 7 2.3308
WDR12 WD repeat domain 12 2.3246
TPX2 TPX2, microtubule-associated 2.314
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.3078
CEP192 centrosomal protein 192kDa 2.3021
THAP12 THAP domain containing 12 2.2909
AUH AU RNA binding protein/enoyl-CoA hydratase 2.2788
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.2749
MAB21L2 mab-21-like 2 (C. elegans) 2.2659
UBE3C ubiquitin protein ligase E3C 2.2522
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.2486
ISCU iron-sulfur cluster assembly enzyme 2.2472
FLG filaggrin 2.2295
GNPAT glyceronephosphate O-acyltransferase 2.2265
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.2226
PUM3 pumilio RNA binding family member 3 2.2194
CDC123 cell division cycle 123 2.2186
ADAM10 ADAM metallopeptidase domain 10 2.21283
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.21105
ZNF106 zinc finger protein 106 2.2101
SAMM50 SAMM50 sorting and assembly machinery component 2.2099
RPL8 ribosomal protein L8 2.2038
LRRC31 leucine rich repeat containing 31 2.1945
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.1932
AVPI1 arginine vasopressin-induced 1 2.1817
CDH20 cadherin 20, type 2 2.1729
NBPF3 neuroblastoma breakpoint family, member 3 2.1658
MTMR4 myotubularin related protein 4 2.1656
KIF13B kinesin family member 13B 2.1645
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.1604
TRAPPC12 trafficking protein particle complex 12 2.154
PRC1 protein regulator of cytokinesis 1 2.1497
ATP5F1C ATP synthase F1 subunit gamma 2.148
TJP2 tight junction protein 2 2.1437
B2M beta-2-microglobulin 2.1435
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.1277
HSPA1A heat shock 70kDa protein 1A 2.122
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.122
EIF4H eukaryotic translation initiation factor 4H 2.1208
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.1186
NFIL3 nuclear factor, interleukin 3 regulated 2.1106
ZBTB11 zinc finger and BTB domain containing 11 2.0964
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.0863
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.0774
RUFY1 RUN and FYVE domain containing 1 2.0742
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.0721
RPL3 ribosomal protein L3 2.0717
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.0686
LMO2 LIM domain only 2 (rhombotin-like 1) 2.0673
PTTG1 pituitary tumor-transforming 1 2.0545
ANXA3 annexin A3 2.0496
GAS1 growth arrest-specific 1 2.0489
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.0463
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.0463
SPG11 spastic paraplegia 11 (autosomal recessive) 2.0455
NPAS3 neuronal PAS domain protein 3 2.0404
CIAO2B cytosolic iron-sulfur assembly component 2B 2.037
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.0364
WDR7 WD repeat domain 7 2.0317
CH25H cholesterol 25-hydroxylase 2.0262
H1-10 H1.10 linker histone 2.0259
ATP5PB ATP synthase peripheral stalk-membrane subunit b 2.0252
MRPL15 mitochondrial ribosomal protein L15 2.0245
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 2.0241
STXBP6 syntaxin binding protein 6 (amisyn) 2.0239
TXNRD1 thioredoxin reductase 1 2.0183
MRPL16 mitochondrial ribosomal protein L16 2.0122
HMGB2 high mobility group box 2 2.0076
FAM53C family with sequence similarity 53, member C 2.0061
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.0047
ZNF165 zinc finger protein 165 2.0008
SCN1A sodium channel, voltage gated, type I alpha subunit 2.0008

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.937
SLC35F2 solute carrier family 35, member F2 -8.7902
TM9SF3 transmembrane 9 superfamily member 3 -6.7051
GRWD1 glutamate-rich WD repeat containing 1 -6.5072
DHRS7 dehydrogenase/reductase (SDR family) member 7 -6.2105
NT5DC2 5'-nucleotidase domain containing 2 -5.5663
MCM3 minichromosome maintenance complex component 3 -5.3359
LOC124907782 dual specificity protein phosphatase 22 -4.9283
VDAC1 voltage-dependent anion channel 1 -4.6478
NPDC1 neural proliferation, differentiation and control, 1 -4.4103
IPO13 importin 13 -4.1725
GTPBP8 GTP-binding protein 8 (putative) -4.1485
BLMH bleomycin hydrolase -3.938
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.61
KIF14 kinesin family member 14 -3.6084
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.598
RNF167 ring finger protein 167 -3.5276
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.4703
ZNF586 zinc finger protein 586 -3.3812
PRKCD protein kinase C, delta -3.2513
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -3.2407
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -3.1013
IRAK4 interleukin-1 receptor-associated kinase 4 -3.0732
RPIA ribose 5-phosphate isomerase A -3.0656
ZNF215 zinc finger protein 215 -3.0281
UBE2C ubiquitin-conjugating enzyme E2C -3.0249
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.9804
MPZL1 myelin protein zero-like 1 -2.9613
POLK polymerase (DNA directed) kappa -2.8525
NOP14 NOP14 nucleolar protein -2.832
ERMAP erythroblast membrane-associated protein (Scianna blood group) -2.8289
ERAP2 endoplasmic reticulum aminopeptidase 2 -2.8075
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.7722
NELL2 NEL-like 2 (chicken) -2.7651
LOXL1 lysyl oxidase-like 1 -2.7632
ADIRF adipogenesis regulatory factor -2.7607
CDC42 cell division cycle 42 -2.75315
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -2.7411
RPN1 ribophorin I -2.7073
FBXO46 F-box protein 46 -2.697
KREMEN2 kringle containing transmembrane protein 2 -2.6925
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.6785
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.6754
S100A13 S100 calcium binding protein A13 -2.67355
SHCBP1 SHC SH2-domain binding protein 1 -2.6724
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.6436
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.6314
DSCC1 DNA replication and sister chromatid cohesion 1 -2.6095
ACTL8 actin-like 8 -2.6013
CENPI centromere protein I -2.60045
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.5892
ANO3 anoctamin 3 -2.5883
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.5823
NDRG1 N-myc downstream regulated 1 -2.5795
BPHL biphenyl hydrolase-like (serine hydrolase) -2.5743
SP140 SP140 nuclear body protein -2.5733
PIBF1 progesterone immunomodulatory binding factor 1 -2.5578
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.556
CD38 CD38 molecule -2.5518
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.531
TBC1D17 TBC1 domain family, member 17 -2.5309
AHDC1 AT hook, DNA binding motif, containing 1 -2.5063
ZNF322 zinc finger protein 322 -2.5019
PNKP polynucleotide kinase 3'-phosphatase -2.4888
DCTN5 dynactin 5 (p25) -2.48525
ZNF432 zinc finger protein 432 -2.4797
NEUROG1 neurogenin 1 -2.4794
TRIM13 tripartite motif containing 13 -2.4653
TAPBP TAP binding protein (tapasin) -2.4528
IL2RB interleukin 2 receptor, beta -2.4224
ANKRD49 ankyrin repeat domain 49 -2.4196
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.4171
ACLY ATP citrate lyase -2.41667
AQP2 aquaporin 2 (collecting duct) -2.4078
CDK3 cyclin-dependent kinase 3 -2.3971
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.3964
GMEB1 glucocorticoid modulatory element binding protein 1 -2.3769
BATF basic leucine zipper transcription factor, ATF-like -2.3698
FANCF Fanconi anemia, complementation group F -2.3689
JUN jun proto-oncogene -2.35253
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.3519
TSPOAP1 TSPO associated protein 1 -2.3489
GYPC glycophorin C (Gerbich blood group) -2.3489
HMX1 H6 family homeobox 1 -2.3465
MUC3B mucin 3B, cell surface associated -2.3437
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.342
CASKIN2 CASK interacting protein 2 -2.3406
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -2.3371
CDC25A cell division cycle 25A -2.33245
PARP1 poly (ADP-ribose) polymerase 1 -2.3006
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.2954
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.29215
MYL9 myosin, light chain 9, regulatory -2.292
NCK2 NCK adaptor protein 2 -2.2898
APOL3 apolipoprotein L, 3 -2.2887
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.28765
RAB36 RAB36, member RAS oncogene family -2.2825
CTSD cathepsin D -2.2763
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.2759
SNX11 sorting nexin 11 -2.27465
IL12RB1 interleukin 12 receptor, beta 1 -2.2738
CARM1 coactivator-associated arginine methyltransferase 1 -2.2709
RFC3 replication factor C (activator 1) 3, 38kDa -2.26755
TSPAN31 tetraspanin 31 -2.2645
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.2631
ZNF124 zinc finger protein 124 -2.2566
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -2.2468
RAP1GAP RAP1 GTPase activating protein -2.2438
CHIT1 chitinase 1 (chitotriosidase) -2.2372
DUSP5 dual specificity phosphatase 5 -2.2348
COPZ2 coatomer protein complex, subunit zeta 2 -2.2327
AUNIP aurora kinase A and ninein interacting protein -2.2301
SUMO4 small ubiquitin-like modifier 4 -2.2291
PCGF2 polycomb group ring finger 2 -2.2267
BLNK B-cell linker -2.2236
RASA4B RAS p21 protein activator 4B -2.2123
AIM2 absent in melanoma 2 -2.2108
RNF123 ring finger protein 123 -2.2076
TMSB15C thymosin beta 15C -2.2041
SH2B2 SH2B adaptor protein 2 -2.2039
SLFN12 schlafen family member 12 -2.2015
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -2.1878
UMOD uromodulin -2.1739
DENND1A DENN/MADD domain containing 1A -2.1729
RAMP2 receptor (G protein-coupled) activity modifying protein 2 -2.1616
ACOT9 acyl-CoA thioesterase 9 -2.1482
LGI2 leucine-rich repeat LGI family, member 2 -2.147
ORC6 origin recognition complex, subunit 6 -2.1436
ZNF768 zinc finger protein 768 -2.1356
OSBP2 oxysterol binding protein 2 -2.1354
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.135
KANK3 KN motif and ankyrin repeat domains 3 -2.1319
AOX1 aldehyde oxidase 1 -2.12935
MFGE8 milk fat globule-EGF factor 8 protein -2.1285
TRAPPC2 trafficking protein particle complex 2 -2.1284
HYOU1 hypoxia up-regulated 1 -2.1165
MSH5 mutS homolog 5 -2.1139
HDAC9 histone deacetylase 9 -2.1136
DRC4 dynein regulatory complex subunit 4 -2.112
PMP22 peripheral myelin protein 22 -2.1119
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -2.10765
UEVLD UEV and lactate/malate dehyrogenase domains -2.1069
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.1063
ZNF574 zinc finger protein 574 -2.1057
MAP7D3 MAP7 domain containing 3 -2.10495
PLA2G2D phospholipase A2, group IID -2.103
IQSEC2 IQ motif and Sec7 domain 2 -2.1024
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.1023
OSGIN1 oxidative stress induced growth inhibitor 1 -2.099
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B -2.0967
RASA4 RAS p21 protein activator 4 -2.09453
WRN Werner syndrome, RecQ helicase-like -2.0939
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -2.0929
HOXA1 homeobox A1 -2.0918
SREK1IP1 SREK1-interacting protein 1 -2.0859
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.0858
GZMK granzyme K (granzyme 3; tryptase II) -2.0843
EXO1 exonuclease 1 -2.078
BAZ2A bromodomain adjacent to zinc finger domain, 2A -2.07663
SMG6 SMG6 nonsense mediated mRNA decay factor -2.0696
PLCH2 phospholipase C, eta 2 -2.0651
HDDC2 HD domain containing 2 -2.065
IRF3 interferon regulatory factor 3 -2.0637
EHD1 EH-domain containing 1 -2.06216
GPALPP1 GPALPP motifs containing 1 -2.0599
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.0596
TPSD1 tryptase delta 1 -2.0586
RIN1 Ras and Rab interactor 1 -2.0559
JUP junction plakoglobin -2.055
BTN3A1 butyrophilin, subfamily 3, member A1 -2.0538
ZNF587 zinc finger protein 587 -2.052
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.0513
CD96 CD96 molecule -2.0486
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.0476
SDC4 syndecan 4 -2.043
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.0365
LTA lymphotoxin alpha -2.0354
FRMD1 FERM domain containing 1 -2.0351
CTSO cathepsin O -2.0342
RPL39L ribosomal protein L39-like -2.0323
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.0301
WDR43 WD repeat domain 43 -2.0247
HOXC4 homeobox C4 -2.0243
ZBTB44 zinc finger and BTB domain containing 44 -2.0224
MID2 midline 2 -2.0192
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.019
BBS7 Bardet-Biedl syndrome 7 -2.0175
ARHGAP15 Rho GTPase activating protein 15 -2.0149
EBI3 Epstein-Barr virus induced 3 -2.0129
CLDN17 claudin 17 -2.0124
MTRF1 mitochondrial translational release factor 1 -2.009
EPOR erythropoietin receptor -2.00842
MRPS2 mitochondrial ribosomal protein S2 -2.006