CRCGN011_HEPG2_24H:K04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-(p-chlorophenyl)-1,1-di?methyl?urea 4.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

118 genes differentially expressed following the CRCGN011_HEPG2_24H:K04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 6.99237
DENND2D DENN/MADD domain containing 2D 5.8232
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.70925
MAMLD1 mastermind-like domain containing 1 5.0
ALDOC aldolase C, fructose-bisphosphate 4.8762
EPN2 epsin 2 4.65765
TREM1 triggering receptor expressed on myeloid cells 1 4.6415
TLR4 toll-like receptor 4 4.5426
WDR7 WD repeat domain 7 3.8707
ADAM10 ADAM metallopeptidase domain 10 3.84547
LYN LYN proto-oncogene, Src family tyrosine kinase 3.75527
PRKCH protein kinase C, eta 3.728
PMM2 phosphomannomutase 2 3.476
LCN2 lipocalin 2 3.4642
UBE2A ubiquitin-conjugating enzyme E2A 3.35868
GTPBP8 GTP-binding protein 8 (putative) 3.2465
KDM3A lysine (K)-specific demethylase 3A 3.1619
DYNLT3 dynein, light chain, Tctex-type 3 2.81635
SCN3A sodium channel, voltage gated, type III alpha subunit 2.7859
SSBP2 single-stranded DNA binding protein 2 2.7377
EPHA3 EPH receptor A3 2.70252
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.5835
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.5355
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.45215
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.42442
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.4125
NOSIP nitric oxide synthase interacting protein 2.4105
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.37575
CTXND1 cortexin domain containing 1 2.37112
SOX5 SRY (sex determining region Y)-box 5 2.3674
NLGN1 neuroligin 1 2.33205
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.29805
GRM5 glutamate receptor, metabotropic 5 2.29192
PARP4 poly (ADP-ribose) polymerase family, member 4 2.29065
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.2882
FLRT1 fibronectin leucine rich transmembrane protein 1 2.24645
GRB10 growth factor receptor-bound protein 10 2.23262
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.2281
SCG5 secretogranin V 2.22125
ADGRB3 adhesion G protein-coupled receptor B3 2.21595
INHA inhibin, alpha 2.2035
TXNL4B thioredoxin-like 4B 2.2023
ENDOD1 endonuclease domain containing 1 2.19007
POU3F2 POU class 3 homeobox 2 2.19
MYO16 myosin XVI 2.17075
TPD52L2 tumor protein D52-like 2 2.16695
TERT telomerase reverse transcriptase 2.1399
TRIM13 tripartite motif containing 13 2.1267
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.12355
CCNA1 cyclin A1 2.10185
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.0958
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.09188
GTPBP2 GTP binding protein 2 2.09165
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.08455
FYN FYN proto-oncogene, Src family tyrosine kinase 2.07285
TEX15 testis expressed 15 2.0605
BIRC2 baculoviral IAP repeat containing 2 2.0596
KIF11 kinesin family member 11 2.05555
SFTPB surfactant protein B 2.05047
ADRB2 adrenoceptor beta 2, surface 2.04955
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.0477
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.04763
FAIM Fas apoptotic inhibitory molecule 2.0462
PGC progastricsin (pepsinogen C) 2.04425
MTMR11 myotubularin related protein 11 2.04015
HDAC9 histone deacetylase 9 2.03375
GPR17 G protein-coupled receptor 17 2.02387
SOX11 SRY (sex determining region Y)-box 11 2.01872
SLITRK3 SLIT and NTRK-like family, member 3 2.01225
MGP matrix Gla protein 2.01
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.002

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.80305
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.2938
ZNF586 zinc finger protein 586 -4.94905
ENOPH1 enolase-phosphatase 1 -4.84035
PCNA proliferating cell nuclear antigen -4.82295
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.7777
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7175
LDHD lactate dehydrogenase D -4.66275
TCTN1 tectonic family member 1 -4.42095
ACAA1 acetyl-CoA acyltransferase 1 -4.33677
USP6NL USP6 N-terminal like -4.3366
MAP7 microtubule-associated protein 7 -4.23105
HMG20B high mobility group 20B -3.90155
PRCP prolylcarboxypeptidase (angiotensinase C) -3.7863
PECR peroxisomal trans-2-enoyl-CoA reductase -3.7327
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.21355
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.09925
COPS4 COP9 signalosome subunit 4 -3.07535
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.9599
TOR1A torsin family 1, member A (torsin A) -2.87827
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.7535
TM9SF2 transmembrane 9 superfamily member 2 -2.6503
PRPF4 pre-mRNA processing factor 4 -2.5902
CDK4 cyclin-dependent kinase 4 -2.5679
OXA1L oxidase (cytochrome c) assembly 1-like -2.5061
GPR137B G protein-coupled receptor 137B -2.49795
ACLY ATP citrate lyase -2.49312
FBXO7 F-box protein 7 -2.48255
BPHL biphenyl hydrolase-like (serine hydrolase) -2.42705
ANAPC10 anaphase promoting complex subunit 10 -2.39505
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.37195
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33835
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.29545
NRIP1 nuclear receptor interacting protein 1 -2.28403
FOS FBJ murine osteosarcoma viral oncogene homolog -2.2788
PLEC plectin -2.27395
KLHL21 kelch-like family member 21 -2.27065
RABEPK Rab9 effector protein with kelch motifs -2.2066
LIAS lipoic acid synthetase -2.16245
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.1153
JMJD7 jumonji domain containing 7 -2.0645
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.05895
MVP major vault protein -2.0418
KRT16 keratin 16, type I -2.03895
GSTM2 glutathione S-transferase mu 2 (muscle) -2.03892
RNF4 ring finger protein 4 -2.021
LSM1 LSM1, U6 small nuclear RNA associated -2.0182