CRCGN011_HEPG2_24H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-(p-chlorophenyl)-1,1-di?methyl?urea 2.46 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN011_HEPG2_24H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.3302
E2F2 E2F transcription factor 2 5.11575
PPARG peroxisome proliferator-activated receptor gamma 4.98055
PRKCH protein kinase C, eta 4.76258
C2CD2 C2 calcium-dependent domain containing 2 4.6992
GATA3 GATA binding protein 3 4.13397
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.0644
TXNL4B thioredoxin-like 4B 3.871
MAP7 microtubule-associated protein 7 3.81428
SSBP2 single-stranded DNA binding protein 2 3.6804
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.62555
PMM2 phosphomannomutase 2 3.3932
PRR15L proline rich 15-like 3.3889
GPER1 G protein-coupled estrogen receptor 1 3.26807
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.15785
RXYLT1 ribitol xylosyltransferase 1 3.14543
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.08545
CYCS cytochrome c, somatic 2.9847
EPHA3 EPH receptor A3 2.81433
COL11A1 collagen, type XI, alpha 1 2.75598
ZNF589 zinc finger protein 589 2.66785
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.65385
KLHL9 kelch-like family member 9 2.59088
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.5525
TEX10 testis expressed 10 2.47825
TCHH trichohyalin 2.458
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.4555
DYNLT3 dynein, light chain, Tctex-type 3 2.3974
TPH1 tryptophan hydroxylase 1 2.3113
GDF10 growth differentiation factor 10 2.2917
ADAM2 ADAM metallopeptidase domain 2 2.26555
GAR1 GAR1 ribonucleoprotein 2.2275
THAP4 THAP domain containing 4 2.2246
ZNF141 zinc finger protein 141 2.2217
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.21905
PLAGL1 pleiomorphic adenoma gene-like 1 2.18802
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.18185
JADE2 jade family PHD finger 2 2.17045
CDCA4 cell division cycle associated 4 2.15025
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.13585
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.12655
SLC49A3 solute carrier family 49 member 3 2.10415
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.07685
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 2.05375
LDHAL6B lactate dehydrogenase A-like 6B 2.03615
ADAM15 ADAM metallopeptidase domain 15 2.03425
ZNF254 zinc finger protein 254 2.0249
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.01785
INSL5 insulin-like 5 2.017
LMO1 LIM domain only 1 (rhombotin 1) 2.00325

decreased expression

Symbol Name Standardized Value
RFC2 replication factor C (activator 1) 2, 40kDa -5.89398
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.447
CD320 CD320 molecule -5.2171
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.14085
CHMP4B charged multivesicular body protein 4B -4.98828
FBXL12 F-box and leucine-rich repeat protein 12 -4.97565
NT5DC2 5'-nucleotidase domain containing 2 -4.9233
FAIM Fas apoptotic inhibitory molecule -4.64965
PCNA proliferating cell nuclear antigen -4.553
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.17535
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.91455
CCNB2 cyclin B2 -3.8396
FGFR4 fibroblast growth factor receptor 4 -3.68447
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.255
GRWD1 glutamate-rich WD repeat containing 1 -3.2058
SNX11 sorting nexin 11 -3.0151
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.71808
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.31235
PRPF4 pre-mRNA processing factor 4 -2.17762
SKIC2 SKI2 subunit of superkiller complex -2.15745
TRIM16 tripartite motif containing 16 -2.1547
CLIP2 CAP-GLY domain containing linker protein 2 -2.1041
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.09235
KIF2C kinesin family member 2C -2.06772
CRTC3 CREB regulated transcription coactivator 3 -2.0284
EIF5 eukaryotic translation initiation factor 5 -2.01725
TMEM160 transmembrane protein 160 -2.01615