CRCGN011_HEPG2_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

705 genes differentially expressed following the CRCGN011_HEPG2_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
UBE2L6 ubiquitin-conjugating enzyme E2L 6 9.6021
FOXO4 forkhead box O4 9.0033
CBR1 carbonyl reductase 1 7.57585
PRKCD protein kinase C, delta 7.3218
HSPA1A heat shock 70kDa protein 1A 7.19885
DNM1 dynamin 1 7.18125
CDPF1 cysteine-rich, DPF motif domain containing 1 6.9094
GPER1 G protein-coupled estrogen receptor 1 6.56047
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 6.5364
ALDOC aldolase C, fructose-bisphosphate 6.38695
SKIC2 SKI2 subunit of superkiller complex 6.2489
CIAO3 cytosolic iron-sulfur assembly component 3 5.91305
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.88315
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.642
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.584
NMU neuromedin U 5.46065
EPHB2 EPH receptor B2 5.4505
LGMN legumain 5.2622
NOTCH1 notch 1 5.18725
AMDHD2 amidohydrolase domain containing 2 5.1254
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.1174
HMG20B high mobility group 20B 5.08537
LCN2 lipocalin 2 5.0
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.9047
LSR lipolysis stimulated lipoprotein receptor 4.87165
EXOSC4 exosome component 4 4.75817
MVP major vault protein 4.6456
STX1A syntaxin 1A (brain) 4.5882
MYLK myosin light chain kinase 4.50055
STK10 serine/threonine kinase 10 4.41582
H2BC12 H2B clustered histone 12 4.35007
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.258
MAP7 microtubule-associated protein 7 4.21727
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.21565
RPP38 ribonuclease P/MRP 38kDa subunit 4.14575
BMP4 bone morphogenetic protein 4 4.1073
TCEA2 transcription elongation factor A (SII), 2 4.0726
DUSP6 dual specificity phosphatase 6 4.05822
WDR44 WD repeat domain 44 3.92905
NCOA3 nuclear receptor coactivator 3 3.88863
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.8203
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.7801
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.71875
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.675
PLS1 plastin 1 3.58915
COG7 component of oligomeric golgi complex 7 3.57045
IGF1R insulin-like growth factor 1 receptor 3.54813
HMOX1 heme oxygenase 1 3.50135
AARS1 alanyl-tRNA synthetase 1 3.48705
CARMIL1 capping protein regulator and myosin 1 linker 1 3.487
LIN37 lin-37 DREAM MuvB core complex component 3.41985
TYW2 tRNA wybutosine-synthesizing protein 2 3.40035
SNPH syntaphilin 3.3473
TRAPPC6A trafficking protein particle complex 6A 3.33165
MACO1 macoilin 1 3.26985
TAC4 tachykinin 4 (hemokinin) 3.248
LAMA5 laminin, alpha 5 3.2275
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 3.21887
FKBP14 FK506 binding protein 14, 22 kDa 3.21735
FHIT fragile histidine triad 3.21515
LEMD3 LEM domain containing 3 3.21215
SSBP2 single-stranded DNA binding protein 2 3.20215
STXBP1 syntaxin binding protein 1 3.1988
ICAM1 intercellular adhesion molecule 1 3.19615
IFT140 intraflagellar transport 140 3.1826
GCC2 GRIP and coiled-coil domain containing 2 3.1438
NDRG1 N-myc downstream regulated 1 3.1034
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.0976
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.0489
ACKR3 atypical chemokine receptor 3 3.0361
PECR peroxisomal trans-2-enoyl-CoA reductase 3.03455
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.00145
CRIPT cysteine-rich PDZ-binding protein 2.9844
YPEL5 yippee-like 5 (Drosophila) 2.96525
PTMS parathymosin 2.9601
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.95192
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.92848
FCHO1 FCH domain only 1 2.89725
ZDHHC6 zinc finger, DHHC-type containing 6 2.89535
GDI1 GDP dissociation inhibitor 1 2.89405
CRIP2 cysteine-rich protein 2 2.8593
BAMBI BMP and activin membrane-bound inhibitor 2.8575
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.85162
ARFIP2 ADP-ribosylation factor interacting protein 2 2.84195
SCGN secretagogin, EF-hand calcium binding protein 2.8175
UNC93B1 unc-93 homolog B1 (C. elegans) 2.8163
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.81428
RNF167 ring finger protein 167 2.809
DOK7 docking protein 7 2.80778
CYTH1 cytohesin 1 2.80347
WNT11 wingless-type MMTV integration site family, member 11 2.78245
JADE2 jade family PHD finger 2 2.766
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.7567
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.7557
RSU1 Ras suppressor protein 1 2.7517
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.74763
AKR1C3 aldo-keto reductase family 1, member C3 2.7361
CDH22 cadherin 22, type 2 2.72355
HDAC4 histone deacetylase 4 2.7228
VAT1 vesicle amine transport 1 2.7221
CCL24 chemokine (C-C motif) ligand 24 2.71915
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.712
WDR25 WD repeat domain 25 2.7086
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.6979
GLCE glucuronic acid epimerase 2.6888
SLC25A44 solute carrier family 25, member 44 2.67633
SEC62 SEC62 homolog (S. cerevisiae) 2.67607
H2AC6 H2A clustered histone 6 2.6711
PPARG peroxisome proliferator-activated receptor gamma 2.6634
MXI1 MAX interactor 1, dimerization protein 2.6588
SYTL2 synaptotagmin-like 2 2.64775
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.63585
ZBTB22 zinc finger and BTB domain containing 22 2.63365
MAGT1 magnesium transporter 1 2.6314
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.62862
TBCCD1 TBCC domain containing 1 2.6212
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.61838
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.60565
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.605
ROGDI rogdi homolog (Drosophila) 2.59865
DYNC2I1 dynein 2 intermediate chain 1 2.59405
TRIB1 tribbles pseudokinase 1 2.59385
VAMP8 vesicle-associated membrane protein 8 2.5809
DACH1 dachshund family transcription factor 1 2.57485
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 2.56255
ADGRG1 adhesion G protein-coupled receptor G1 2.55885
NIT1 nitrilase 1 2.5555
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.55457
FBXO2 F-box protein 2 2.5544
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.54653
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.54238
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.5404
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.53997
ZNF91 zinc finger protein 91 2.5383
GPR162 G protein-coupled receptor 162 2.53335
PLCH2 phospholipase C, eta 2 2.5246
TCEAL9 transcription elongation factor A like 9 2.5236
CDA cytidine deaminase 2.51955
USP6NL USP6 N-terminal like 2.5106
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.4979
DNM3 dynamin 3 2.49785
KCTD17 potassium channel tetramerization domain containing 17 2.49625
BIRC2 baculoviral IAP repeat containing 2 2.49535
LBR lamin B receptor 2.49375
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.4865
RUSC2 RUN and SH3 domain containing 2 2.4854
CCP110 centriolar coiled coil protein 110kDa 2.4847
KLHL9 kelch-like family member 9 2.47892
MRTFB myocardin related transcription factor B 2.47195
DEFA6 defensin, alpha 6, Paneth cell-specific 2.4718
GPR137B G protein-coupled receptor 137B 2.47095
PLPP6 phospholipid phosphatase 6 2.46935
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2.46807
DSE dermatan sulfate epimerase 2.45575
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.44873
INSM1 insulinoma-associated 1 2.44475
JRKL JRK-like 2.43655
ICAM5 intercellular adhesion molecule 5, telencephalin 2.43465
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.41948
EPHA3 EPH receptor A3 2.41835
MT1F metallothionein 1F 2.41202
HPCAL1 hippocalcin-like 1 2.40965
TPD52-MRPS28 TPD52-MRPS28 readthrough 2.40874
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.4057
SHARPIN SHANK-associated RH domain interactor 2.39815
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.39665
ZMAT4 zinc finger, matrin-type 4 2.3929
SMAD6 SMAD family member 6 2.3902
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.3823
SETD3 SET domain containing 3 2.37845
SCGB1D1 secretoglobin, family 1D, member 1 2.37175
TMEM50A transmembrane protein 50A 2.36665
SLC10A3 solute carrier family 10, member 3 2.36025
ABHD4 abhydrolase domain containing 4 2.35595
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.3552
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.3499
GOLGA2 golgin A2 2.34801
ZC2HC1A zinc finger, C2HC-type containing 1A 2.348
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.3429
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.34133
ELL elongation factor RNA polymerase II 2.33305
BORCS6 BLOC-1 related complex subunit 6 2.3277
ZC3H3 zinc finger CCCH-type containing 3 2.32625
YIPF3 Yip1 domain family, member 3 2.3179
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.31695
UNKL unkempt family zinc finger-like 2.31475
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.31318
CRYM crystallin, mu 2.31145
INTS3 integrator complex subunit 3 2.31065
GLRX glutaredoxin (thioltransferase) 2.30335
BEX3 brain expressed X-linked 3 2.29555
RASL11B RAS-like, family 11, member B 2.2943
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.29355
REPS2 RALBP1 associated Eps domain containing 2 2.2874
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.28545
TREM2 triggering receptor expressed on myeloid cells 2 2.28275
DCTN1 dynactin 1 2.27287
PRICKLE3 prickle homolog 3 (Drosophila) 2.27105
EXOC2 exocyst complex component 2 2.27055
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.26467
ELOB elongin B 2.26205
CA2 carbonic anhydrase II 2.25655
WBP1L WW domain binding protein 1-like 2.25275
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.2518
HSF1 heat shock transcription factor 1 2.25052
FAM131A family with sequence similarity 131, member A 2.25015
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.24923
GSTP1 glutathione S-transferase pi 1 2.2482
MAGED2 melanoma antigen family D2 2.24817
RASA4 RAS p21 protein activator 4 2.24617
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.24565
LMF1 lipase maturation factor 1 2.24432
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.24238
LITAF lipopolysaccharide-induced TNF factor 2.23925
FUCA1 fucosidase, alpha-L- 1, tissue 2.2335
TUFT1 tuftelin 1 2.2317
RNF111 ring finger protein 111 2.22785
TMEM14A transmembrane protein 14A 2.22605
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.22525
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.22155
ABHD6 abhydrolase domain containing 6 2.21935
LTB lymphotoxin beta (TNF superfamily, member 3) 2.2108
CD9 CD9 molecule 2.20935
SFXN1 sideroflexin 1 2.20845
CNPY4 canopy FGF signaling regulator 4 2.2066
HPSE heparanase 2.2063
MYLIP myosin regulatory light chain interacting protein 2.20445
CORO1A coronin, actin binding protein, 1A 2.2023
SCARB1 scavenger receptor class B, member 1 2.20193
SARAF store-operated calcium entry-associated regulatory factor 2.20165
PLA2G15 phospholipase A2, group XV 2.20005
C1QA complement component 1, q subcomponent, A chain 2.19885
NPR1 natriuretic peptide receptor 1 2.1839
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.18325
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.18235
CGRRF1 cell growth regulator with ring finger domain 1 2.1816
FNDC3B fibronectin type III domain containing 3B 2.17965
TMEM184B transmembrane protein 184B 2.17385
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.17235
GOLPH3L golgi phosphoprotein 3-like 2.1717
EFR3A EFR3 homolog A (S. cerevisiae) 2.17018
UBXN7 UBX domain protein 7 2.16565
ADAM9 ADAM metallopeptidase domain 9 2.16435
ATG101 autophagy related 101 2.1633
F11R F11 receptor 2.16182
SBDS Shwachman-Bodian-Diamond syndrome 2.1616
ZNF107 zinc finger protein 107 2.15965
NOSIP nitric oxide synthase interacting protein 2.15755
BCL2L1 BCL2-like 1 2.15492
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.1543
CTSB cathepsin B 2.1522
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.14713
RUBCN rubicon autophagy regulator 2.14555
ZCCHC10 zinc finger, CCHC domain containing 10 2.14235
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.13913
NME7 NME/NM23 family member 7 2.13655
BIN3 bridging integrator 3 2.13625
SSTR3 somatostatin receptor 3 2.1352
HPCA hippocalcin 2.13415
NGB neuroglobin 2.1303
IGFBP3 insulin-like growth factor binding protein 3 2.12972
DYNLT1 dynein, light chain, Tctex-type 1 2.1276
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.12695
FAF2 Fas associated factor family member 2 2.12493
DOHH deoxyhypusine hydroxylase/monooxygenase 2.1211
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.11733
BBX bobby sox homolog (Drosophila) 2.11385
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.11355
EBI3 Epstein-Barr virus induced 3 2.10785
AVPI1 arginine vasopressin-induced 1 2.10725
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.10694
POM121 POM121 transmembrane nucleoporin 2.1062
IFT20 intraflagellar transport 20 2.10545
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.1032
MAPRE3 microtubule-associated protein, RP/EB family, member 3 2.0999
RAB21 RAB21, member RAS oncogene family 2.0998
GAL3ST1 galactose-3-O-sulfotransferase 1 2.0996
HSPB1 heat shock 27kDa protein 1 2.0995
RUSF1 RUS family member 1 2.09835
EFNB1 ephrin-B1 2.09815
CLEC16A C-type lectin domain family 16, member A 2.0957
SIX1 SIX homeobox 1 2.09345
CORO2A coronin, actin binding protein, 2A 2.09305
SYNDIG1 synapse differentiation inducing 1 2.08725
EGR1 early growth response 1 2.08685
DBN1 drebrin 1 2.0822
TLE5 TLE family member 5, transcriptional modulator 2.0814
TM9SF2 transmembrane 9 superfamily member 2 2.08135
PDLIM7 PDZ and LIM domain 7 (enigma) 2.07823
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.07695
GAL3ST4 galactose-3-O-sulfotransferase 4 2.0766
FXYD7 FXYD domain containing ion transport regulator 7 2.07465
SPINK4 serine peptidase inhibitor, Kazal type 4 2.07365
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.072
SPATS2 spermatogenesis associated, serine-rich 2 2.0716
NCDN neurochondrin 2.07085
PCSK1 proprotein convertase subtilisin/kexin type 1 2.0679
MLF2 myeloid leukemia factor 2 2.0625
CLCF1 cardiotrophin-like cytokine factor 1 2.06042
BBC3 BCL2 binding component 3 2.05845
PARP6 poly (ADP-ribose) polymerase family, member 6 2.05395
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.05315
ATG2A autophagy related 2A 2.0529
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 2.05155
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.0514
CCNJL cyclin J-like 2.04655
CRX cone-rod homeobox 2.04605
ZSCAN16 zinc finger and SCAN domain containing 16 2.0456
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.04275
LHX6 LIM homeobox 6 2.03545
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.03373
RPA3 replication protein A3, 14kDa 2.02765
CXXC4 CXXC finger protein 4 2.02755
DGCR2 DiGeorge syndrome critical region gene 2 2.0266
ZNF212 zinc finger protein 212 2.02505
SGF29 SAGA complex associated factor 29 2.02157
IDUA iduronidase, alpha-L- 2.02028
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.01665
TXNRD1 thioredoxin reductase 1 2.0159
NECAP1 NECAP endocytosis associated 1 2.01405
ZMIZ1 zinc finger, MIZ-type containing 1 2.0121
SAP30L SAP30-like 2.00705
ITGA6 integrin, alpha 6 2.00653
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.00385
TUSC2 tumor suppressor candidate 2 2.00355
TMEM165 transmembrane protein 165 2.0015

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -9.32395
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -9.08805
CD320 CD320 molecule -8.96205
TCTN1 tectonic family member 1 -8.7774
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -8.02105
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -7.7617
TLCD3A TLC domain containing 3A -7.7437
NUP85 nucleoporin 85kDa -7.4524
MRPS16 mitochondrial ribosomal protein S16 -7.39455
UBE2C ubiquitin-conjugating enzyme E2C -7.2252
PCCB propionyl CoA carboxylase, beta polypeptide -6.90435
PGM1 phosphoglucomutase 1 -6.86885
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -6.59665
PLK1 polo-like kinase 1 -6.3589
SPAG7 sperm associated antigen 7 -6.28535
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -6.1954
LOC124907782 dual specificity protein phosphatase 22 -6.0609
CDC20 cell division cycle 20 -6.03695
KEAP1 kelch-like ECH-associated protein 1 -5.99815
RPIA ribose 5-phosphate isomerase A -5.93455
CCNA2 cyclin A2 -5.70937
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -5.6138
GALE UDP-galactose-4-epimerase -5.5763
FAIM Fas apoptotic inhibitory molecule -5.54145
C5 complement component 5 -5.45705
ADI1 acireductone dioxygenase 1 -5.37275
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -5.19255
SOAT2 sterol O-acyltransferase 2 -5.18297
CDK4 cyclin-dependent kinase 4 -5.17305
SCAND1 SCAN domain containing 1 -5.16345
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -5.05945
ZW10 zw10 kinetochore protein -4.9287
STAP2 signal transducing adaptor family member 2 -4.84895
TCERG1 transcription elongation regulator 1 -4.7755
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.75085
LRRC41 leucine rich repeat containing 41 -4.5657
NNT nicotinamide nucleotide transhydrogenase -4.5396
MRPS7 mitochondrial ribosomal protein S7 -4.436
LDHD lactate dehydrogenase D -4.40985
TATDN2 TatD DNase domain containing 2 -4.37285
MACF1 microtubule-actin crosslinking factor 1 -4.20137
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.19195
GYS1 glycogen synthase 1 (muscle) -4.18845
DERA deoxyribose-phosphate aldolase (putative) -4.1377
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.0784
CHEK1 checkpoint kinase 1 -4.0618
GTPBP6 GTP binding protein 6 (putative) -4.04565
TMEM109 transmembrane protein 109 -3.9542
GNAS GNAS complex locus -3.95144
HADH hydroxyacyl-CoA dehydrogenase -3.94998
RRAGA Ras-related GTP binding A -3.90325
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.85675
TTC19 tetratricopeptide repeat domain 19 -3.82175
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.61345
KIF14 kinesin family member 14 -3.591
SLC35F2 solute carrier family 35, member F2 -3.5607
FOXM1 forkhead box M1 -3.55715
DEPDC1 DEP domain containing 1 -3.5256
SPAG4 sperm associated antigen 4 -3.52155
TMEM97 transmembrane protein 97 -3.51365
TERT telomerase reverse transcriptase -3.50965
ANXA7 annexin A7 -3.50283
MSMO1 methylsterol monooxygenase 1 -3.4293
YME1L1 YME1-like 1 ATPase -3.40333
PLA1A phospholipase A1 member A -3.40195
TPM1 tropomyosin 1 (alpha) -3.37707
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.34295
AURKA aurora kinase A -3.33737
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.3254
MSL1 male-specific lethal 1 homolog (Drosophila) -3.3147
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.307
TROAP trophinin associated protein -3.29575
ITGB5 integrin, beta 5 -3.27927
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -3.26203
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -3.2302
OXA1L oxidase (cytochrome c) assembly 1-like -3.20925
CAPN3 calpain 3, (p94) -3.20743
FOSL1 FOS-like antigen 1 -3.20365
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.19425
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.17225
PPIE peptidylprolyl isomerase E (cyclophilin E) -3.16392
PROSER1 proline and serine rich 1 -3.1472
SLC35B1 solute carrier family 35, member B1 -3.14715
DCK deoxycytidine kinase -3.13935
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.12915
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.1225
ENDOG endonuclease G -3.1183
KLHL21 kelch-like family member 21 -3.1043
SQOR sulfide quinone oxidoreductase -3.09255
IDE insulin-degrading enzyme -3.08925
ATMIN ATM interactor -3.0795
ZBED1 zinc finger, BED-type containing 1 -3.0632
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.06155
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -3.0553
PNPLA3 patatin-like phospholipase domain containing 3 -3.02655
VDAC1 voltage-dependent anion channel 1 -3.0089
SLC30A10 solute carrier family 30, member 10 -3.00165
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.99835
EXOSC8 exosome component 8 -2.9826
CD99 CD99 molecule -2.96312
PEBP1 phosphatidylethanolamine binding protein 1 -2.96205
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.94435
NVL nuclear VCP-like -2.9223
THOC1 THO complex 1 -2.89645
HMGN2 high mobility group nucleosomal binding domain 2 -2.88685
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.87235
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.87065
GRWD1 glutamate-rich WD repeat containing 1 -2.8595
WDR7 WD repeat domain 7 -2.8566
ACTN2 actinin, alpha 2 -2.84584
THBS2 thrombospondin 2 -2.84475
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.84168
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.8372
MIS18A MIS18 kinetochore protein A -2.8331
MRPL58 mitochondrial ribosomal protein L58 -2.8249
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.8068
IPO5 importin 5 -2.80072
PARP1 poly (ADP-ribose) polymerase 1 -2.7863
OXCT1 3-oxoacid CoA transferase 1 -2.7823
FBXO7 F-box protein 7 -2.776
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.75865
RCOR3 REST corepressor 3 -2.75395
HMGA2 high mobility group AT-hook 2 -2.7482
FKRP fukutin related protein -2.74215
KIF15 kinesin family member 15 -2.73775
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.73685
FAM111A family with sequence similarity 111, member A -2.7315
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.7295
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.7271
MED24 mediator complex subunit 24 -2.72535
PEG3 paternally expressed 3 -2.72482
LYRM1 LYR motif containing 1 -2.71865
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.7078
BIRC5 baculoviral IAP repeat containing 5 -2.66478
MELK maternal embryonic leucine zipper kinase -2.65695
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.6487
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.63971
SUMO4 small ubiquitin-like modifier 4 -2.6361
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.62695
ZIM2 zinc finger, imprinted 2 -2.6244
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.6203
COCH cochlin -2.6203
CNTLN centlein, centrosomal protein -2.6172
ANXA6 annexin A6 -2.6159
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.61265
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.60365
PAIP1 poly(A) binding protein interacting protein 1 -2.59009
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.58755
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.58715
LRRC2 leucine rich repeat containing 2 -2.5854
RPL3L ribosomal protein L3-like -2.58355
ANAPC1 anaphase promoting complex subunit 1 -2.5834
KIF4A kinesin family member 4A -2.58025
ABT1 activator of basal transcription 1 -2.5739
RBM14-RBM4 RBM14-RBM4 readthrough -2.5735
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.56905
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.56865
SLC35E2B solute carrier family 35, member E2B -2.5628
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.56215
MRPL23 mitochondrial ribosomal protein L23 -2.5614
PDCD6IP programmed cell death 6 interacting protein -2.55775
RFC3 replication factor C (activator 1) 3, 38kDa -2.54717
CPNE3 copine III -2.54575
MTG1 mitochondrial ribosome-associated GTPase 1 -2.5456
WASHC4 WASH complex subunit 4 -2.54498
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.5416
DLAT dihydrolipoamide S-acetyltransferase -2.53958
PHF11 PHD finger protein 11 -2.5354
RCC1L RCC1 like -2.5307
WEE1 WEE1 G2 checkpoint kinase -2.51927
TMEM94 transmembrane protein 94 -2.51545
GSTCD glutathione S-transferase, C-terminal domain containing -2.50355
RWDD2B RWD domain containing 2B -2.49715
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.49015
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.4845
MCM5 minichromosome maintenance complex component 5 -2.48378
FBXW4 F-box and WD repeat domain containing 4 -2.472
CDC25B cell division cycle 25B -2.4695
KRT34 keratin 34, type I -2.4673
DNA2 DNA replication helicase/nuclease 2 -2.4654
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.4636
DDR2 discoidin domain receptor tyrosine kinase 2 -2.4605
LAD1 ladinin 1 -2.45305
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.45
NEK3 NIMA-related kinase 3 -2.44865
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.4477
ZDHHC7 zinc finger, DHHC-type containing 7 -2.43965
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.43885
HDDC2 HD domain containing 2 -2.43677
USP22 ubiquitin specific peptidase 22 -2.43622
JPT1 Jupiter microtubule associated homolog 1 -2.4322
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.42365
WDR77 WD repeat domain 77 -2.4232
KRT33A keratin 33A, type I -2.4228
KIAA1549L KIAA1549-like -2.4186
PARN poly(A)-specific ribonuclease -2.4089
EIF5 eukaryotic translation initiation factor 5 -2.40615
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.4046
MAGED4B melanoma antigen family D4B -2.3995
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.3994
MSRA methionine sulfoxide reductase A -2.39865
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.3941
TYRP1 tyrosinase-related protein 1 -2.3935
ZNF318 zinc finger protein 318 -2.38965
ZBTB35 zinc finger and BTB domain containing 35 -2.38842
BCL7B B-cell CLL/lymphoma 7B -2.387
SLF2 SMC5-SMC6 complex localization factor 2 -2.3817
CENPE centromere protein E, 312kDa -2.3765
BARD1 BRCA1 associated RING domain 1 -2.3712
KLHL41 kelch-like family member 41 -2.36885
TRIP13 thyroid hormone receptor interactor 13 -2.3683
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.36635
SLC38A10 solute carrier family 38, member 10 -2.3659
HMGXB4 HMG box domain containing 4 -2.36355
ECH1 enoyl CoA hydratase 1, peroxisomal -2.35515
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.3491
CENPA centromere protein A -2.34835
ADSL adenylosuccinate lyase -2.34825
PCNT pericentrin -2.34575
HJURP Holliday junction recognition protein -2.34495
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.3391
CDC25A cell division cycle 25A -2.33525
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.3319
PKNOX2 PBX/knotted 1 homeobox 2 -2.32347
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.31958
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.3174
TEX30 testis expressed 30 -2.31445
GYG2 glycogenin 2 -2.31002
NID1 nidogen 1 -2.30415
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.30075
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.29135
ZZZ3 zinc finger, ZZ-type containing 3 -2.28555
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.28425
ASF1B anti-silencing function 1B histone chaperone -2.28395
KRT31 keratin 31, type I -2.27725
CDK12 cyclin-dependent kinase 12 -2.2756
TOMM34 translocase of outer mitochondrial membrane 34 -2.27395
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.27365
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.2712
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.2705
PGLS 6-phosphogluconolactonase -2.2684
DAPL1 death associated protein-like 1 -2.2652
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.2642
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.2638
FADS2 fatty acid desaturase 2 -2.2615
TRIB3 tribbles pseudokinase 3 -2.25955
HAS2 hyaluronan synthase 2 -2.25505
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.25032
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.24907
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.24765
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.24405
MLH1 mutL homolog 1 -2.2371
SNRPA small nuclear ribonucleoprotein polypeptide A -2.2364
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.23415
GTPBP8 GTP-binding protein 8 (putative) -2.2315
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.22785
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.2248
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.2233
CASC3 cancer susceptibility candidate 3 -2.21825
PGC progastricsin (pepsinogen C) -2.21455
H2AX H2A.X variant histone -2.21335
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.21205
NLRX1 NLR family member X1 -2.2116
TRDN triadin -2.2074
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.20655
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2057
CTSO cathepsin O -2.2014
RTRAF RNA transcription, translation and transport factor -2.1962
SOAT1 sterol O-acyltransferase 1 -2.19233
SYPL1 synaptophysin-like 1 -2.18968
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.1853
UBE2A ubiquitin-conjugating enzyme E2A -2.17855
MGST2 microsomal glutathione S-transferase 2 -2.17625
DKK1 dickkopf WNT signaling pathway inhibitor 1 -2.1757
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.17355
LHFPL6 LHFPL tetraspan subfamily member 6 -2.17145
GATA4 GATA binding protein 4 -2.16795
PYGM phosphorylase, glycogen, muscle -2.16755
SMPX small muscle protein, X-linked -2.16535
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.16345
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.16015
TRMT5 tRNA methyltransferase 5 -2.15985
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.1582
PHIP pleckstrin homology domain interacting protein -2.15788
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.1555
NLGN4Y neuroligin 4, Y-linked -2.1551
CRYZ crystallin, zeta (quinone reductase) -2.1546
PUM3 pumilio RNA binding family member 3 -2.1542
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.1523
VGLL3 vestigial-like family member 3 -2.15175
HLA-DOB major histocompatibility complex, class II, DO beta -2.15085
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.14913
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.14563
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.145
DPP3 dipeptidyl-peptidase 3 -2.14445
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.1406
CKM creatine kinase, muscle -2.1381
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.13725
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.1279
RBM34 RNA binding motif protein 34 -2.12192
FXN frataxin -2.11855
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.11775
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.1157
SSH1 slingshot protein phosphatase 1 -2.11557
DSN1 DSN1, MIS12 kinetochore complex component -2.11505
RBL1 retinoblastoma-like 1 -2.1139
XPO1 exportin 1 -2.11335
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.1111
FANCG Fanconi anemia, complementation group G -2.1085
ZNF451 zinc finger protein 451 -2.1072
DAZAP1 DAZ associated protein 1 -2.10655
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.1011
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.10105
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.09882
USP9Y ubiquitin specific peptidase 9, Y-linked -2.09818
AIDA axin interactor, dorsalization associated -2.09595
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.0942
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.09253
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.09155
MYD88 myeloid differentiation primary response 88 -2.09125
PXMP2 peroxisomal membrane protein 2, 22kDa -2.09067
ACOT2 acyl-CoA thioesterase 2 -2.08725
SCFD1 sec1 family domain containing 1 -2.08245
NUP88 nucleoporin 88kDa -2.07963
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.0796
ZC3H14 zinc finger CCCH-type containing 14 -2.07765
DHCR7 7-dehydrocholesterol reductase -2.07627
ECI2 enoyl-CoA delta isomerase 2 -2.0729
ZXDC ZXD family zinc finger C -2.07165
SCAF8 SR-related CTD-associated factor 8 -2.0691
LGALS7B lectin, galactoside-binding, soluble, 7B -2.06895
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.06695
MAPK13 mitogen-activated protein kinase 13 -2.0647
ENO3 enolase 3 (beta, muscle) -2.06425
PADI2 peptidyl arginine deiminase, type II -2.06355
CDK1 cyclin-dependent kinase 1 -2.06352
MTCH2 mitochondrial carrier 2 -2.0627
CTCF CCCTC-binding factor (zinc finger protein) -2.06215
EMC8 ER membrane protein complex subunit 8 -2.06105
USP1 ubiquitin specific peptidase 1 -2.06033
CHL1 cell adhesion molecule L1-like -2.05875
CHPT1 choline phosphotransferase 1 -2.0562
CDK7 cyclin-dependent kinase 7 -2.05535
NIT2 nitrilase family, member 2 -2.05495
CD207 CD207 molecule, langerin -2.0528
FGL1 fibrinogen-like 1 -2.0496
TCHH trichohyalin -2.04945
FNBP4 formin binding protein 4 -2.04855
NID2 nidogen 2 (osteonidogen) -2.0477
GTSE1 G-2 and S-phase expressed 1 -2.04728
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.04665
HMGN3 high mobility group nucleosomal binding domain 3 -2.0463
SEPTIN9 septin 9 -2.04628
AKAP17A A kinase (PRKA) anchor protein 17A -2.04612
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.04488
CPB2 carboxypeptidase B2 (plasma) -2.0435
NEK2 NIMA-related kinase 2 -2.04047
COQ6 coenzyme Q6 monooxygenase -2.04025
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.03788
SLC6A16 solute carrier family 6, member 16 -2.0367
PHTF1 putative homeodomain transcription factor 1 -2.03452
TMEM11 transmembrane protein 11 -2.0338
RYR3 ryanodine receptor 3 -2.03215
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.03175
HMGB2 high mobility group box 2 -2.029
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.0289
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.0277
MARCHF5 membrane associated ring-CH-type finger 5 -2.02665
DONSON downstream neighbor of SON -2.02455
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.02105
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.02065
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.01432
MANEA mannosidase, endo-alpha -2.0117
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00585
DPF3 D4, zinc and double PHD fingers, family 3 -2.0031
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.0023
POLK polymerase (DNA directed) kappa -2.00005