CRCGN011_HEPG2_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropyl-n-(3-chloro?phenyl)carbamate 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN011_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 6.75377
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 5.25185
LCN2 lipocalin 2 5.2047
ADGRE5 adhesion G protein-coupled receptor E5 5.17635
PPARG peroxisome proliferator-activated receptor gamma 5.14065
PEX11A peroxisomal biogenesis factor 11 alpha 5.13045
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.9592
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.802
WDTC1 WD and tetratricopeptide repeats 1 4.53555
E2F2 E2F transcription factor 2 4.22145
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.20825
FRS2 fibroblast growth factor receptor substrate 2 4.03925
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.016
RAI14 retinoic acid induced 14 3.97145
HOXA10 homeobox A10 3.9196
CYCS cytochrome c, somatic 3.6017
STIMATE STIM activating enhancer 3.53165
SSBP2 single-stranded DNA binding protein 2 3.49
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.36295
ATP11B ATPase, class VI, type 11B 3.348
KIF5C kinesin family member 5C 3.28317
IPO13 importin 13 3.19985
CCL2 chemokine (C-C motif) ligand 2 3.0832
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.81295
JADE2 jade family PHD finger 2 2.62273
FCHO1 FCH domain only 1 2.58485
LOXL1 lysyl oxidase-like 1 2.42835
FPGS folylpolyglutamate synthase 2.42645
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.26185
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.1966
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.1627
PAOX polyamine oxidase (exo-N4-amino) 2.1281
KLHL9 kelch-like family member 9 2.07872
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.07865
COCH cochlin 2.07085

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.44299
MAPK13 mitogen-activated protein kinase 13 -5.8304
KDM3A lysine (K)-specific demethylase 3A -5.4693
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.182
LDHD lactate dehydrogenase D -4.88985
NGRN neugrin, neurite outgrowth associated -4.3085
PCNA proliferating cell nuclear antigen -3.8317
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.6726
SESN1 sestrin 1 -3.14275
ARID5B AT rich interactive domain 5B (MRF1-like) -2.9685
PSRC1 proline/serine-rich coiled-coil 1 -2.71765
CCNB2 cyclin B2 -2.4407
CAB39 calcium binding protein 39 -2.4155
TTC31 tetratricopeptide repeat domain 31 -2.3196
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.24112
REG1B regenerating islet-derived 1 beta -2.1926
ACYP2 acylphosphatase 2, muscle type -2.06775
PEX11B peroxisomal biogenesis factor 11 beta -2.06495