CRCGN011_HEPG2_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropyl-n-(3-chloro?phenyl)carbamate 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN011_HEPG2_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
MOK MOK protein kinase 10.0
BACE2 beta-site APP-cleaving enzyme 2 10.0
CBR3 carbonyl reductase 3 6.2562
SIRT3 sirtuin 3 5.37953
NMU neuromedin U 5.21215
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.16375
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.71455
UBQLN2 ubiquilin 2 4.63465
PPARG peroxisome proliferator-activated receptor gamma 4.32195
PRR15L proline rich 15-like 4.25625
GSTZ1 glutathione S-transferase zeta 1 3.8047
TREM1 triggering receptor expressed on myeloid cells 1 3.7549
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.72985
MAP7 microtubule-associated protein 7 3.38072
TLR4 toll-like receptor 4 3.36665
WDTC1 WD and tetratricopeptide repeats 1 3.2944
TIAM1 T-cell lymphoma invasion and metastasis 1 3.24478
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.11133
SOCS2 suppressor of cytokine signaling 2 3.07025
ATP11B ATPase, class VI, type 11B 2.992
LOC122526780 uncharacterized LOC122526780 2.80375
PRKCH protein kinase C, eta 2.71422
RIC8A RIC8 guanine nucleotide exchange factor A 2.6197
GPATCH8 G patch domain containing 8 2.51285
RNF167 ring finger protein 167 2.4538
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 2.34435
DIPK1A divergent protein kinase domain 1A 2.32842
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.289
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.23838
ACTMAP actin maturation protease 2.21335
UFM1 ubiquitin-fold modifier 1 2.1997
OLFM4 olfactomedin 4 2.193
R3HDM4 R3H domain containing 4 2.17545
GID8 GID complex subunit 8 2.149
DYNLT3 dynein, light chain, Tctex-type 3 2.13855
COCH cochlin 2.12075
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.10308
NDE1 nudE neurodevelopment protein 1 2.06305
PARP1 poly (ADP-ribose) polymerase 1 2.04475
HS1BP3 HCLS1 binding protein 3 2.02445
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.022
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.01391
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.01385

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.07165
PCNA proliferating cell nuclear antigen -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.816
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.66275
FGFR4 fibroblast growth factor receptor 4 -4.55725
RPS5 ribosomal protein S5 -4.49375
PGM1 phosphoglucomutase 1 -4.2904
PECR peroxisomal trans-2-enoyl-CoA reductase -3.9185
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.58658
SPAG4 sperm associated antigen 4 -3.3422
DERA deoxyribose-phosphate aldolase (putative) -3.11575
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.09195
MAPK13 mitogen-activated protein kinase 13 -2.93818
NRIP1 nuclear receptor interacting protein 1 -2.7189
PROS1 protein S (alpha) -2.36235
SLC35F2 solute carrier family 35, member F2 -2.31295
PANX1 pannexin 1 -2.2077
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.0293
LRRN2 leucine rich repeat neuronal 2 -2.02485
ELOVL4 ELOVL fatty acid elongase 4 -2.01355
GLDC glycine dehydrogenase (decarboxylating) -2.0082
CALML5 calmodulin-like 5 -2.00195