CRCGN011_HEPG2_24H:K18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropyl-n-(3-chloro?phenyl)carbamate 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN011_HEPG2_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 5.13745
CCDC92 coiled-coil domain containing 92 5.126
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.0003
LCN2 lipocalin 2 5.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.99045
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.76425
CSK c-src tyrosine kinase 4.66275
DYNLT3 dynein, light chain, Tctex-type 3 4.48955
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.31255
EVL Enah/Vasp-like 4.13855
ATP11B ATPase, class VI, type 11B 3.98725
GARRE1 granule associated Rac and RHOG effector 1 3.7866
VGLL4 vestigial-like family member 4 3.4194
NMU neuromedin U 3.40315
TREM1 triggering receptor expressed on myeloid cells 1 2.9297
COL11A1 collagen, type XI, alpha 1 2.82728
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.69565
PMM2 phosphomannomutase 2 2.461
PYCR1 pyrroline-5-carboxylate reductase 1 2.39275
NUAK1 NUAK family, SNF1-like kinase, 1 2.354
POMZP3 POM121 and ZP3 fusion 2.31512
DDIT4 DNA-damage-inducible transcript 4 2.1862
SOD3 superoxide dismutase 3, extracellular 2.14605
BPIFA1 BPI fold containing family A, member 1 2.00315

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -10.0
GDF15 growth differentiation factor 15 -6.90915
TSPAN4 tetraspanin 4 -5.2044
DNM1L dynamin 1-like -5.1956
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.87935
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.41405
NISCH nischarin -4.29075
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.03885
MAPK13 mitogen-activated protein kinase 13 -4.02755
CD320 CD320 molecule -3.16465
TM9SF3 transmembrane 9 superfamily member 3 -3.0793
OXA1L oxidase (cytochrome c) assembly 1-like -2.99545
CPNE3 copine III -2.93085
RGS2 regulator of G-protein signaling 2 -2.87765
VDAC1 voltage-dependent anion channel 1 -2.82005
NRIP1 nuclear receptor interacting protein 1 -2.2406
DERA deoxyribose-phosphate aldolase (putative) -2.17665
PWP1 PWP1 homolog (S. cerevisiae) -2.04313