CRCGN011_HEPG2_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.6537
PPARG peroxisome proliferator-activated receptor gamma 5.2867
MYLK myosin light chain kinase 5.1214
C2CD2 C2 calcium-dependent domain containing 2 4.9513
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.91725
MAP7 microtubule-associated protein 7 4.91207
TLR4 toll-like receptor 4 4.78565
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.56445
DDIT4 DNA-damage-inducible transcript 4 4.3101
SNAP25 synaptosomal-associated protein, 25kDa 4.30347
CBR3 carbonyl reductase 3 4.03585
KDM5A lysine (K)-specific demethylase 5A 3.6707
CHN1 chimerin 1 3.62835
HOXA10 homeobox A10 3.55568
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.2976
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.25405
COL11A1 collagen, type XI, alpha 1 3.15328
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.01275
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.86005
CCL2 chemokine (C-C motif) ligand 2 2.8189
PLSCR3 phospholipid scramblase 3 2.74787
ABHD4 abhydrolase domain containing 4 2.7315
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.678
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.61065
KLHL9 kelch-like family member 9 2.60395
MTX1 metaxin 1 2.48065
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.4655
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.39795
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.3939
PHGDH phosphoglycerate dehydrogenase 2.38175
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.3519
GPATCH8 G patch domain containing 8 2.32655
FOXO4 forkhead box O4 2.31465
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.21023
PEX11B peroxisomal biogenesis factor 11 beta 2.12535
TNS3 tensin 3 2.113
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.11
ATXN1 ataxin 1 2.1055
SRFBP1 serum response factor binding protein 1 2.09535
FCHO1 FCH domain only 1 2.09315
S100A11 S100 calcium binding protein A11 2.0736
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.07045
MMUT methylmalonyl-CoA mutase 2.02755
S100P S100 calcium binding protein P 2.01895
SLC35B1 solute carrier family 35, member B1 2.01665
NARS1 asparaginyl-tRNA synthetase 1 2.0165
EPHA3 EPH receptor A3 2.00037

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.449
CD320 CD320 molecule -6.91955
CDC20 cell division cycle 20 -5.8335
LDHD lactate dehydrogenase D -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.6981
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.18255
KDM3A lysine (K)-specific demethylase 3A -4.11985
CHMP4B charged multivesicular body protein 4B -4.10072
FGFR4 fibroblast growth factor receptor 4 -4.0137
ADI1 acireductone dioxygenase 1 -3.98
HMG20B high mobility group 20B -3.48078
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.3678
SLC35F2 solute carrier family 35, member F2 -3.2604
GDF15 growth differentiation factor 15 -3.1598
HLA-DMA major histocompatibility complex, class II, DM alpha -3.1038
NVL nuclear VCP-like -3.0322
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.96693
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.95625
NGRN neugrin, neurite outgrowth associated -2.8317
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.76685
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.68442
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.66825
NPDC1 neural proliferation, differentiation and control, 1 -2.4816
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.339
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 -2.31925
PYDC1 PYD (pyrin domain) containing 1 -2.31455
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.29255
CPA2 carboxypeptidase A2 (pancreatic) -2.29025
PYY peptide YY -2.2467
EMC9 ER membrane protein complex subunit 9 -2.24495
OXA1L oxidase (cytochrome c) assembly 1-like -2.2322
SCIN scinderin -2.21805
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.19025
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.18862
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.17095
NDC1 NDC1 transmembrane nucleoporin -2.1684
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.166
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.16342
SETD4 SET domain containing 4 -2.12185
CELA3B chymotrypsin-like elastase family, member 3B -2.11775
ZNF586 zinc finger protein 586 -2.11445
KLF1 Kruppel-like factor 1 (erythroid) -2.0956
MED9 mediator complex subunit 9 -2.08855
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 -2.08442
LRRC42 leucine rich repeat containing 42 -2.08155
FLNC filamin C, gamma -2.0812
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.0801
CELA3A chymotrypsin-like elastase family, member 3A -2.07678
MAP2K5 mitogen-activated protein kinase kinase 5 -2.07197
PRLH prolactin releasing hormone -2.065
HROB homologous recombination factor with OB-fold -2.05505
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.0482
PGM5 phosphoglucomutase 5 -2.0473
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.01655
YJU2 YJU2 splicing factor homolog -2.00665
DCK deoxycytidine kinase -2.006