CRCGN011_HEPG2_24H:K21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN011_HEPG2_24H:K21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SYNE2 spectrin repeat containing, nuclear envelope 2 5.39855
CIAO3 cytosolic iron-sulfur assembly component 3 5.35385
RPP38 ribonuclease P/MRP 38kDa subunit 5.14435
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.06175
LCN2 lipocalin 2 5.0
TREM1 triggering receptor expressed on myeloid cells 1 4.8865
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.8844
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8812
VAV3 vav 3 guanine nucleotide exchange factor 4.74592
NOTCH1 notch 1 4.5191
GSTZ1 glutathione S-transferase zeta 1 4.4564
CCNF cyclin F 4.09072
MAP7 microtubule-associated protein 7 3.61007
TLR4 toll-like receptor 4 3.5898
ATP11B ATPase, class VI, type 11B 3.40255
STIMATE STIM activating enhancer 3.2174
SSBP2 single-stranded DNA binding protein 2 3.03693
COQ8A coenzyme Q8A 3.03285
GPER1 G protein-coupled estrogen receptor 1 2.99528
DDIT4 DNA-damage-inducible transcript 4 2.7719
BIRC2 baculoviral IAP repeat containing 2 2.6593
JADE2 jade family PHD finger 2 2.64878
GADD45A growth arrest and DNA-damage-inducible, alpha 2.63305
HLA-DRA major histocompatibility complex, class II, DR alpha 2.61627
ADGRE5 adhesion G protein-coupled receptor E5 2.54155
MEST mesoderm specific transcript 2.53745
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.50605
DIPK1A divergent protein kinase domain 1A 2.37972
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.33395
SIRT3 sirtuin 3 2.32415
AARS1 alanyl-tRNA synthetase 1 2.2704
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.2142
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.1861
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.16558
MSRB1 methionine sulfoxide reductase B1 2.0962
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.08185
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.0484
KIAA0319L KIAA0319-like 2.04715

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.50705
THAP11 THAP domain containing 11 -4.9261
LDHD lactate dehydrogenase D -4.78685
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.78185
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.5334
ADI1 acireductone dioxygenase 1 -4.22555
OXA1L oxidase (cytochrome c) assembly 1-like -3.7749
GNAS GNAS complex locus -3.60654
CTNND1 catenin (cadherin-associated protein), delta 1 -3.56217
GDF15 growth differentiation factor 15 -3.3824
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.31862
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.17392
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.0957
GRWD1 glutamate-rich WD repeat containing 1 -3.0735
ITGB1BP1 integrin beta 1 binding protein 1 -2.6318
XPO7 exportin 7 -2.42583
SIN3B SIN3 transcription regulator family member B -2.3869
TMEM51 transmembrane protein 51 -2.23715
SLC35F2 solute carrier family 35, member F2 -2.2323
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.2227
PHC1 polyhomeotic homolog 1 (Drosophila) -2.2059
LSAMP limbic system-associated membrane protein -2.1373
PODXL podocalyxin-like -2.1296
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.017
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.01615