CRCGN011_HEPG2_24H:K22 Gene Set
Genes
47 genes differentially expressed following the CRCGN011_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
MLLT11
|
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
|
5.5557
|
|
CXCL2
|
chemokine (C-X-C motif) ligand 2
|
5.03215
|
|
LCN2
|
lipocalin 2
|
5.0
|
|
P4HTM
|
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
|
4.6519
|
|
NOTCH1
|
notch 1
|
4.4767
|
|
LYN
|
LYN proto-oncogene, Src family tyrosine kinase
|
4.40958
|
|
PRKCH
|
protein kinase C, eta
|
4.22503
|
|
CCL2
|
chemokine (C-C motif) ligand 2
|
3.2599
|
|
SRC
|
SRC proto-oncogene, non-receptor tyrosine kinase
|
2.83873
|
|
CYCS
|
cytochrome c, somatic
|
2.77865
|
|
EPN2
|
epsin 2
|
2.75058
|
|
PCK2
|
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
|
2.65225
|
|
CHN1
|
chimerin 1
|
2.6291
|
|
GPER1
|
G protein-coupled estrogen receptor 1
|
2.5298
|
|
TNIP1
|
TNFAIP3 interacting protein 1
|
2.396
|
|
MTHFD2
|
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
|
2.3673
|
|
DDIT4
|
DNA-damage-inducible transcript 4
|
2.35895
|
|
GSTZ1
|
glutathione S-transferase zeta 1
|
2.3433
|
|
TBXA2R
|
thromboxane A2 receptor
|
2.33104
|
|
PLEKHB1
|
pleckstrin homology domain containing, family B (evectins) member 1
|
2.18715
|
|
POLD4
|
polymerase (DNA-directed), delta 4, accessory subunit
|
2.0959
|
|
PGM1
|
phosphoglucomutase 1
|
2.09375
|
|
RAB32
|
RAB32, member RAS oncogene family
|
2.0808
|
|
NSDHL
|
NAD(P) dependent steroid dehydrogenase-like
|
2.0261
|
|
UNC50
|
unc-50 homolog (C. elegans)
|
2.02025
|
|
PHF10
|
PHD finger protein 10
|
2.01455
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
CCNB2
|
cyclin B2
|
-6.99185
|
|
LAP3
|
leucine aminopeptidase 3
|
-5.3778
|
|
MRPS2
|
mitochondrial ribosomal protein S2
|
-5.11395
|
|
CDC20
|
cell division cycle 20
|
-5.0
|
|
LDHD
|
lactate dehydrogenase D
|
-4.79125
|
|
UGDH
|
UDP-glucose 6-dehydrogenase
|
-4.74835
|
|
IARS2
|
isoleucyl-tRNA synthetase 2, mitochondrial
|
-4.52715
|
|
OXA1L
|
oxidase (cytochrome c) assembly 1-like
|
-3.90465
|
|
DERA
|
deoxyribose-phosphate aldolase (putative)
|
-3.375
|
|
FGFR4
|
fibroblast growth factor receptor 4
|
-3.2757
|
|
PCNA
|
proliferating cell nuclear antigen
|
-2.97645
|
|
MAPK13
|
mitogen-activated protein kinase 13
|
-2.9421
|
|
GRWD1
|
glutamate-rich WD repeat containing 1
|
-2.45415
|
|
BTNL8
|
butyrophilin-like 8
|
-2.39175
|
|
SNX11
|
sorting nexin 11
|
-2.35502
|
|
GHR
|
growth hormone receptor
|
-2.14195
|
|
ZMIZ1
|
zinc finger, MIZ-type containing 1
|
-2.08255
|
|
TOMM34
|
translocase of outer mitochondrial membrane 34
|
-2.0784
|
|
TOPBP1
|
topoisomerase (DNA) II binding protein 1
|
-2.05195
|
|
NHEJ1
|
nonhomologous end-joining factor 1
|
-2.03495
|
|
SMIM5
|
small integral membrane protein 5
|
-2.01557
|
