CRCGN011_HEPG2_24H:K23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN011_HEPG2_24H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 7.3719
RPP38 ribonuclease P/MRP 38kDa subunit 5.2627
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.1375
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.87485
ADGRE5 adhesion G protein-coupled receptor E5 4.73795
NMU neuromedin U 4.67115
CDPF1 cysteine-rich, DPF motif domain containing 1 4.64205
SMIM40 small integral membrane protein 40 4.6302
LCN2 lipocalin 2 4.56125
GSTZ1 glutathione S-transferase zeta 1 3.9533
TREM1 triggering receptor expressed on myeloid cells 1 3.7827
EPN2 epsin 2 3.73752
EVL Enah/Vasp-like 3.25265
ABHD6 abhydrolase domain containing 6 3.1639
SSBP2 single-stranded DNA binding protein 2 3.14565
GPER1 G protein-coupled estrogen receptor 1 2.9397
PFKL phosphofructokinase, liver 2.93005
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.7778
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.68217
GMPPA GDP-mannose pyrophosphorylase A 2.6641
GATD3 glutamine amidotransferase class 1 domain containing 3 2.58502
GPATCH8 G patch domain containing 8 2.41723
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.41225
SMG5 SMG5 nonsense mediated mRNA decay factor 2.37795
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.24725
ORM1 orosomucoid 1 2.23675
COPZ1 coatomer protein complex, subunit zeta 1 2.1149
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.11255
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.1112
TOP2B topoisomerase (DNA) II beta 180kDa 2.09585
SEPHS2 selenophosphate synthetase 2 2.038
FOXO4 forkhead box O4 2.0308
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.02665

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
MAPK13 mitogen-activated protein kinase 13 -5.96662
MAP7 microtubule-associated protein 7 -4.6888
CDC20 cell division cycle 20 -4.66275
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.45035
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.37255
TRIB3 tribbles pseudokinase 3 -4.22855
CCNB2 cyclin B2 -4.06225
CD58 CD58 molecule -3.58325
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.24458
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.90947
CSNK1E casein kinase 1, epsilon -2.83183
TLCD3A TLC domain containing 3A -2.7084
KLF11 Kruppel-like factor 11 -2.6508
ZMYM1 zinc finger, MYM-type 1 -2.64905
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.6034
FEZF2 FEZ family zinc finger 2 -2.54325
YME1L1 YME1-like 1 ATPase -2.52968
ITGB1BP1 integrin beta 1 binding protein 1 -2.44897
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.36747
ZW10 zw10 kinetochore protein -2.3557
CCDC88C coiled-coil domain containing 88C -2.3479
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.3313
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.32355
PIWIL1 piwi-like RNA-mediated gene silencing 1 -2.2294
BEND5 BEN domain containing 5 -2.21975
ASCL2 achaete-scute family bHLH transcription factor 2 -2.19825
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.1884
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.18185
FRRS1L ferric-chelate reductase 1-like -2.16855
PRKN parkin RBR E3 ubiquitin protein ligase -2.15955
DMAP1 DNA methyltransferase 1 associated protein 1 -2.15405
NRGN neurogranin (protein kinase C substrate, RC3) -2.12285
H2BC17 H2B clustered histone 17 -2.1118
TTBK2 tau tubulin kinase 2 -2.11075
ACOXL acyl-CoA oxidase-like -2.09
KRTAP9-9 keratin associated protein 9-9 -2.07945
OPN1MW3 opsin 1, medium wave sensitive 3 -2.0772
ASB4 ankyrin repeat and SOCS box containing 4 -2.07705
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.07115
FAM169A family with sequence similarity 169, member A -2.0609
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.03745
PGM1 phosphoglucomutase 1 -2.02205
FAM135A family with sequence similarity 135, member A -2.019
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -2.01195
AGBL3 ATP/GTP binding protein-like 3 -2.01095
ZNF334 zinc finger protein 334 -2.00935
DGKE diacylglycerol kinase, epsilon 64kDa -2.00215