CRCGN011_HEPG2_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

136 genes differentially expressed following the CRCGN011_HEPG2_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FAIM Fas apoptotic inhibitory molecule 5.44995
STIMATE STIM activating enhancer 5.20695
LCN2 lipocalin 2 4.3154
SQOR sulfide quinone oxidoreductase 4.0576
LYN LYN proto-oncogene, Src family tyrosine kinase 3.92468
NMU neuromedin U 3.78635
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.67018
CYCS cytochrome c, somatic 3.581
GLOD4 glyoxalase domain containing 4 3.5787
PMM2 phosphomannomutase 2 3.50145
TENT4A terminal nucleotidyltransferase 4A 3.4531
MEST mesoderm specific transcript 3.3686
SMNDC1 survival motor neuron domain containing 1 3.35545
BIRC2 baculoviral IAP repeat containing 2 3.13395
UGDH UDP-glucose 6-dehydrogenase 3.0308
CCL2 chemokine (C-C motif) ligand 2 3.02785
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.98005
WDTC1 WD and tetratricopeptide repeats 1 2.96807
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.84955
C2CD2 C2 calcium-dependent domain containing 2 2.823
RAI14 retinoic acid induced 14 2.7209
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.60785
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.6073
TESK1 testis-specific kinase 1 2.57135
TEX10 testis expressed 10 2.5481
GPER1 G protein-coupled estrogen receptor 1 2.42815
CGRRF1 cell growth regulator with ring finger domain 1 2.4108
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.3418
RAP2A RAP2A, member of RAS oncogene family 2.34165
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.31585
FASTKD5 FAST kinase domains 5 2.28515
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.2705
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.2458
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.2314
BTG3 BTG family, member 3 2.22128
TMEM50A transmembrane protein 50A 2.2004
UBE2O ubiquitin-conjugating enzyme E2O 2.1669
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.15445
LBR lamin B receptor 2.12525
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.11465
TOP2A topoisomerase (DNA) II alpha 170kDa 2.1085
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.1051
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.06915
GARRE1 granule associated Rac and RHOG effector 1 2.0567
NFIL3 nuclear factor, interleukin 3 regulated 2.0362
NVL nuclear VCP-like 2.0353
TMPRSS6 transmembrane protease, serine 6 2.0084

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.64825
MAPK13 mitogen-activated protein kinase 13 -5.72765
SCAND1 SCAN domain containing 1 -5.6039
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.51115
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.3607
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.35355
CBR1 carbonyl reductase 1 -5.0736
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.05475
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.8551
GDF15 growth differentiation factor 15 -4.7135
PCNA proliferating cell nuclear antigen -4.66275
KDM3A lysine (K)-specific demethylase 3A -4.569
LDHD lactate dehydrogenase D -4.37455
TRAP1 TNF receptor-associated protein 1 -4.3302
MAP7 microtubule-associated protein 7 -4.23643
ARID5B AT rich interactive domain 5B (MRF1-like) -4.1308
CCNB2 cyclin B2 -3.94125
USP6NL USP6 N-terminal like -3.7716
GNAS GNAS complex locus -3.73379
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.66245
CRTAP cartilage associated protein -3.55135
RFC2 replication factor C (activator 1) 2, 40kDa -3.49665
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.4895
SLC35F2 solute carrier family 35, member F2 -3.3049
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -3.25245
CCNB1 cyclin B1 -3.11395
HEATR1 HEAT repeat containing 1 -3.0919
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.06525
DERA deoxyribose-phosphate aldolase (putative) -2.9456
CAPNS1 calpain, small subunit 1 -2.75655
TMEM147 transmembrane protein 147 -2.7242
HMG20B high mobility group 20B -2.59783
SLC16A6 solute carrier family 16, member 6 -2.5892
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.58773
CD58 CD58 molecule -2.57618
WASHC4 WASH complex subunit 4 -2.56817
ZNF134 zinc finger protein 134 -2.56665
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.56608
SLC35B1 solute carrier family 35, member B1 -2.54985
ZNF304 zinc finger protein 304 -2.54195
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.5362
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.51675
ZNF587B zinc finger protein 587B -2.50955
VDAC1 voltage-dependent anion channel 1 -2.48787
RGS2 regulator of G-protein signaling 2 -2.48325
STAT1 signal transducer and activator of transcription 1, 91kDa -2.47277
RPS5 ribosomal protein S5 -2.45305
LOC124904942 uncharacterized LOC124904942 -2.40935
TBCB tubulin folding cofactor B -2.36047
FZD7 frizzled class receptor 7 -2.34815
PRPF4 pre-mRNA processing factor 4 -2.34748
ZNF217 zinc finger protein 217 -2.3184
HYI hydroxypyruvate isomerase (putative) -2.2901
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.2802
CATSPER2 cation channel, sperm associated 2 -2.27725
TSC22D4 TSC22 domain family, member 4 -2.27715
ZIM3 zinc finger, imprinted 3 -2.24625
POM121 POM121 transmembrane nucleoporin -2.2225
CASQ2 calsequestrin 2 (cardiac muscle) -2.2076
GLTP glycolipid transfer protein -2.2011
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific -2.1974
DND1 DND microRNA-mediated repression inhibitor 1 -2.18665
STK32B serine/threonine kinase 32B -2.1811
ELOB elongin B -2.1773
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.1675
UBE2M ubiquitin-conjugating enzyme E2M -2.152
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.1462
VPREB1 pre-B lymphocyte 1 -2.1453
TBXT T-box transcription factor T -2.13135
HOXA3 homeobox A3 -2.1293
GLRX5 glutaredoxin 5 -2.11225
FHL2 four and a half LIM domains 2 -2.08525
DUSP13A dual specificity phosphatase 13A -2.08425
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.08255
ZMYND8 zinc finger, MYND-type containing 8 -2.07925
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.07675
ZNF419 zinc finger protein 419 -2.06343
MAP4 microtubule-associated protein 4 -2.0505
QPCT glutaminyl-peptide cyclotransferase -2.05015
ZNF761 zinc finger protein 761 -2.04885
ZNF587 zinc finger protein 587 -2.0462
ZNF548 zinc finger protein 548 -2.0457
RNF167 ring finger protein 167 -2.02965
NPPA natriuretic peptide A -2.02685
SNRPC small nuclear ribonucleoprotein polypeptide C -2.02675
MGLL monoglyceride lipase -2.02625
LOC128031832 uncharacterized LOC128031832 -2.0221
PPP6C protein phosphatase 6, catalytic subunit -2.01307