CRCGN011_HEPG2_24H:L04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN011_HEPG2_24H:L04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCH protein kinase C, eta 6.52965
CXCL2 chemokine (C-X-C motif) ligand 2 5.3799
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.80875
MYLK myosin light chain kinase 4.67895
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.6708
TLR4 toll-like receptor 4 4.57
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.11295
LCN2 lipocalin 2 3.63485
ABHD6 abhydrolase domain containing 6 3.29778
TIAM1 T-cell lymphoma invasion and metastasis 1 3.23618
LSR lipolysis stimulated lipoprotein receptor 3.18975
PRR15L proline rich 15-like 3.1827
CCNF cyclin F 3.13345
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.948
COL11A1 collagen, type XI, alpha 1 2.91898
IQGAP1 IQ motif containing GTPase activating protein 1 2.90395
KLF13 Kruppel-like factor 13 2.67275
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.656
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.65303
ZFAND3 zinc finger, AN1-type domain 3 2.53575
FOXN2 forkhead box N2 2.53285
HLA-DRA major histocompatibility complex, class II, DR alpha 2.52728
MEST mesoderm specific transcript 2.465
NOSIP nitric oxide synthase interacting protein 2.46495
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.4066
JADE2 jade family PHD finger 2 2.38198
TREM1 triggering receptor expressed on myeloid cells 1 2.38075
BMP6 bone morphogenetic protein 6 2.2433
DMTF1 cyclin D binding myb-like transcription factor 1 2.21002
OPRPN opiorphin prepropeptide 2.20075
CTSL cathepsin L 2.193
FASTKD5 FAST kinase domains 5 2.15415
CFP complement factor properdin 2.10865
CAPN6 calpain 6 2.06675
NEMP1 nuclear envelope integral membrane protein 1 2.06495
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.05702
SLC49A3 solute carrier family 49 member 3 2.04345
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.0407
ELF2 E74-like factor 2 (ets domain transcription factor) 2.0255
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.02424
FMO5 flavin containing monooxygenase 5 2.0178

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -5.31675
NT5DC2 5'-nucleotidase domain containing 2 -5.2621
VAT1 vesicle amine transport 1 -4.9767
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.87135
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.8401
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.767
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.6745
CDC20 cell division cycle 20 -4.66275
LDHD lactate dehydrogenase D -4.64385
CD320 CD320 molecule -4.5208
DERA deoxyribose-phosphate aldolase (putative) -3.89165
CCNB2 cyclin B2 -3.80005
YME1L1 YME1-like 1 ATPase -3.50368
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.3702
PCNA proliferating cell nuclear antigen -3.24635
ETFB electron-transfer-flavoprotein, beta polypeptide -3.2248
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.128
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.04165
EIF5 eukaryotic translation initiation factor 5 -2.99509
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.99195
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.9728
BDKRB1 bradykinin receptor B1 -2.93165
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.87567
OXA1L oxidase (cytochrome c) assembly 1-like -2.8501
CPNE3 copine III -2.6232
RNFT1-DT RNFT1 divergent transcript -2.59365
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5091
NABP2 nucleic acid binding protein 2 -2.48165
LCMT1 leucine carboxyl methyltransferase 1 -2.47825
BDKRB2 bradykinin receptor B2 -2.449
SGF29 SAGA complex associated factor 29 -2.42198
RFC2 replication factor C (activator 1) 2, 40kDa -2.40575
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.40405
WDR91 WD repeat domain 91 -2.3755
LTBP4 latent transforming growth factor beta binding protein 4 -2.34595
RAB36 RAB36, member RAS oncogene family -2.29175
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.28377
EXD3 exonuclease 3'-5' domain containing 3 -2.2485
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -2.24465
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.2338
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -2.2328
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.18218
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.1757
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.16535
OR10H1 olfactory receptor, family 10, subfamily H, member 1 -2.13505
POLH polymerase (DNA directed), eta -2.1033
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.09975
ZNF276 zinc finger protein 276 -2.07905
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.0191
GNL1 guanine nucleotide binding protein-like 1 -2.01365