CRCGN011_HEPG2_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN011_HEPG2_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.5614
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.29725
CXCL2 chemokine (C-X-C motif) ligand 2 5.0621
PPARG peroxisome proliferator-activated receptor gamma 4.95215
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.85225
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.83465
EAPP E2F-associated phosphoprotein 4.64855
BACE2 beta-site APP-cleaving enzyme 2 4.61585
MYLK myosin light chain kinase 4.43465
MOK MOK protein kinase 4.05335
PRKCH protein kinase C, eta 4.03425
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.01095
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.8402
PEX11A peroxisomal biogenesis factor 11 alpha 3.59387
CYCS cytochrome c, somatic 3.024
GPATCH8 G patch domain containing 8 2.9573
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.94088
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.83885
TIAM1 T-cell lymphoma invasion and metastasis 1 2.82952
SOCS2 suppressor of cytokine signaling 2 2.80005
CCNF cyclin F 2.78618
SSBP2 single-stranded DNA binding protein 2 2.77538
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.58297
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.5786
CHN1 chimerin 1 2.561
JADE2 jade family PHD finger 2 2.35702
FASTKD5 FAST kinase domains 5 2.23435
GJA1 gap junction protein, alpha 1, 43kDa 2.2092
COL11A1 collagen, type XI, alpha 1 2.20633
TRAM2 translocation associated membrane protein 2 2.1611
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.13855
BAX BCL2-associated X protein 2.12222
EMP2 epithelial membrane protein 2 2.07785

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.52375
AURKB aurora kinase B -6.3377
VAT1 vesicle amine transport 1 -5.56
NT5DC2 5'-nucleotidase domain containing 2 -4.90605
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6187
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.90555
GNAS GNAS complex locus -3.16662
LYPLA1 lysophospholipase I -3.11788
HEATR1 HEAT repeat containing 1 -2.69007
TBC1D31 TBC1 domain family, member 31 -2.5701
GDF15 growth differentiation factor 15 -2.29445
PRPF4 pre-mRNA processing factor 4 -2.25865
ITGB1BP1 integrin beta 1 binding protein 1 -2.11573
EIF5 eukaryotic translation initiation factor 5 -2.09895
C5 complement component 5 -2.0482
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.0067