CRCGN011_HEPG2_24H:L07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiodianiline 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

152 genes differentially expressed following the CRCGN011_HEPG2_24H:L07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.39285
E2F2 E2F transcription factor 2 5.33725
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.3304
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.2626
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.01905
NOTCH1 notch 1 5.0122
CHMP6 charged multivesicular body protein 6 4.92625
CSK c-src tyrosine kinase 4.91515
STIMATE STIM activating enhancer 4.8834
AMDHD2 amidohydrolase domain containing 2 4.85415
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8023
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.7611
PPARG peroxisome proliferator-activated receptor gamma 4.66685
MYLK myosin light chain kinase 4.62395
CARMIL1 capping protein regulator and myosin 1 linker 1 4.49205
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.2453
CTSL cathepsin L 3.8525
LCN2 lipocalin 2 3.53805
GPATCH8 G patch domain containing 8 3.35768
VAV3 vav 3 guanine nucleotide exchange factor 3.32587
GPER1 G protein-coupled estrogen receptor 1 3.28307
SIRT3 sirtuin 3 3.18327
CHN1 chimerin 1 3.06445
RNF167 ring finger protein 167 2.9938
TIAM1 T-cell lymphoma invasion and metastasis 1 2.91398
COL11A1 collagen, type XI, alpha 1 2.91368
ZNF589 zinc finger protein 589 2.85938
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.85745
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.84485
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.836
ERCC5 excision repair cross-complementation group 5 2.64375
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.53635
CLCN7 chloride channel, voltage-sensitive 7 2.46207
AMN amnion associated transmembrane protein 2.3439
MYBPC3 myosin binding protein C, cardiac 2.31485
EVL Enah/Vasp-like 2.16625
UNC119 unc-119 homolog (C. elegans) 2.16265
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.1567
WDR6 WD repeat domain 6 2.15135
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.1507
RHOG ras homolog family member G 2.1045
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.08995
HSPA1A heat shock 70kDa protein 1A 2.0738
MAN2B2 mannosidase, alpha, class 2B, member 2 2.05735
MORN1 MORN repeat containing 1 2.0547
MBD1 methyl-CpG binding domain protein 1 2.0545
VSTM4 V-set and transmembrane domain containing 4 2.05275
MNMIP1 manchette microtubule inner protein 1 2.04655
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.0354
SGSH N-sulfoglucosamine sulfohydrolase 2.0278
SNX15 sorting nexin 15 2.01865
FASTKD5 FAST kinase domains 5 2.0119
NT5C 5', 3'-nucleotidase, cytosolic 2.00905
COPZ2 coatomer protein complex, subunit zeta 2 2.00685

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
MRPS2 mitochondrial ribosomal protein S2 -5.449
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.29805
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.28935
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.1733
DNM1L dynamin 1-like -5.1356
GDF15 growth differentiation factor 15 -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.8552
TUBB6 tubulin, beta 6 class V -4.84865
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.83605
TLCD3A TLC domain containing 3A -4.72625
MAP7 microtubule-associated protein 7 -4.64108
CD320 CD320 molecule -4.34395
CCNB2 cyclin B2 -4.1822
ADI1 acireductone dioxygenase 1 -4.0439
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.74753
GNAS GNAS complex locus -3.65386
TCERG1 transcription elongation regulator 1 -3.53275
TBCB tubulin folding cofactor B -3.3631
CAPNS1 calpain, small subunit 1 -3.2878
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.24085
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.22565
TMEM147 transmembrane protein 147 -3.13045
CDKN3 cyclin-dependent kinase inhibitor 3 -2.97295
PGM1 phosphoglucomutase 1 -2.9715
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.9472
NABP1 nucleic acid binding protein 1 -2.73455
ZNF571 zinc finger protein 571 -2.62815
RPE65 retinal pigment epithelium-specific protein 65kDa -2.59055
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.58225
CPVL carboxypeptidase, vitellogenic-like -2.5714
PCDHGA8 protocadherin gamma subfamily A, 8 -2.56945
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.56045
SEMG2 semenogelin II -2.55985
DAZL deleted in azoospermia-like -2.55905
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.53995
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -2.532
RAP1GAP2 RAP1 GTPase activating protein 2 -2.4986
RGPD2 RANBP2-like and GRIP domain containing 2 -2.49805
GET1 guided entry of tail-anchored proteins factor 1 -2.46575
NUP155 nucleoporin 155kDa -2.45595
DGKE diacylglycerol kinase, epsilon 64kDa -2.4529
LDHAL6B lactate dehydrogenase A-like 6B -2.44645
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.42935
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.40112
CHEK1 checkpoint kinase 1 -2.40007
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -2.3957
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.36285
PEDS1 plasmanylethanolamine desaturase 1 -2.3571
MANEA mannosidase, endo-alpha -2.3505
HIPK3 homeodomain interacting protein kinase 3 -2.34622
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.34505
NKX2-2 NK2 homeobox 2 -2.3362
UBE2S ubiquitin-conjugating enzyme E2S -2.32855
PTTG1 pituitary tumor-transforming 1 -2.2696
PCDHB3 protocadherin beta 3 -2.2685
ZNF345 zinc finger protein 345 -2.26105
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.2603
CATSPERG catsper channel auxiliary subunit gamma -2.25745
ACTA1 actin, alpha 1, skeletal muscle -2.2545
SEMG1 semenogelin I -2.25
PCDHA9 protocadherin alpha 9 -2.23865
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -2.23365
ZNF780A zinc finger protein 780A -2.2336
DCAF17 DDB1 and CUL4 associated factor 17 -2.2177
TEP1 telomerase-associated protein 1 -2.21725
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -2.20085
SNX16 sorting nexin 16 -2.19225
RGPD8 RANBP2-like and GRIP domain containing 8 -2.1911
PRDM13 PR domain containing 13 -2.18535
ELP5 elongator acetyltransferase complex subunit 5 -2.18365
CGRRF1 cell growth regulator with ring finger domain 1 -2.16875
ZFP30 ZFP30 zinc finger protein -2.1626
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 -2.16175
MSTN myostatin -2.16165
KLHL12 kelch-like family member 12 -2.14135
ZNF780B zinc finger protein 780B -2.13205
TSC22D1 TSC22 domain family, member 1 -2.12745
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.12065
CNGA3 cyclic nucleotide gated channel alpha 3 -2.11945
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.1005
SPAG6 sperm associated antigen 6 -2.08962
TBX2 T-box 2 -2.07332
GCH1 GTP cyclohydrolase 1 -2.0729
DIXDC1 DIX domain containing 1 -2.07225
TTLL7 tubulin tyrosine ligase-like family member 7 -2.0596
MTRF1L mitochondrial translational release factor 1-like -2.05475
MED21 mediator complex subunit 21 -2.04052
ASCL2 achaete-scute family bHLH transcription factor 2 -2.03875
ZNF391 zinc finger protein 391 -2.03363
CRISP2 cysteine-rich secretory protein 2 -2.02885
ZBTB33 zinc finger and BTB domain containing 33 -2.0187
ZNF529 zinc finger protein 529 -2.0178
LIN37 lin-37 DREAM MuvB core complex component -2.0163
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.0153
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -2.01442
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.00715
PNLIPRP2 pancreatic lipase-related protein 2 -2.0021