CRCGN011_HEPG2_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiodianiline 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN011_HEPG2_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.53695
UBQLN2 ubiquilin 2 5.27615
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.1294
PRR15L proline rich 15-like 3.31935
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.98077
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.9139
CHEK2 checkpoint kinase 2 2.80835
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.73545
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.5851
LCN2 lipocalin 2 2.53845
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.51202
FCHO1 FCH domain only 1 2.45865
MAST2 microtubule associated serine/threonine kinase 2 2.36695
PLSCR3 phospholipid scramblase 3 2.34957
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.31932
FERMT1 fermitin family member 1 2.31052
NMU neuromedin U 2.2545
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.24885
IGBP1 immunoglobulin (CD79A) binding protein 1 2.15635
LOC122526780 uncharacterized LOC122526780 2.1387
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.1365
CAV1 caveolin 1, caveolae protein, 22kDa 2.08973
HAUS7 HAUS augmin-like complex, subunit 7 2.07295
NUP37 nucleoporin 37kDa 2.06795
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.0319

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -8.27295
GNAS GNAS complex locus -7.51221
PECR peroxisomal trans-2-enoyl-CoA reductase -5.3418
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.05565
LDHD lactate dehydrogenase D -4.81815
TRIB3 tribbles pseudokinase 3 -4.6435
MAP7 microtubule-associated protein 7 -4.56997
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.15363
ZDHHC6 zinc finger, DHHC-type containing 6 -4.06505
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.8718
SPAG4 sperm associated antigen 4 -3.0784
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.993
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.87805
NRIP1 nuclear receptor interacting protein 1 -2.85253
FASTKD5 FAST kinase domains 5 -2.7681
BEAN1 brain expressed, associated with NEDD4, 1 -2.6633
RNF167 ring finger protein 167 -2.62015
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.58295
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.4272
TDRD1 tudor domain containing 1 -2.4093
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.37645
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3611
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.3254
TRPS1 trichorhinophalangeal syndrome I -2.3054
NAXD NAD(P)HX dehydratase -2.265
PPT2 palmitoyl-protein thioesterase 2 -2.25365
RAD51C RAD51 paralog C -2.22837
ZNF668 zinc finger protein 668 -2.2218
DNM3 dynamin 3 -2.21865
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.20995
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.20675
ZNF512B zinc finger protein 512B -2.17903
TMEM209 transmembrane protein 209 -2.1744
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.17138
MTRF1L mitochondrial translational release factor 1-like -2.16625
CTNND2 catenin (cadherin-associated protein), delta 2 -2.16515
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.16235
COL4A4 collagen, type IV, alpha 4 -2.1529
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.14595
FAM163A family with sequence similarity 163, member A -2.13215
FOXN2 forkhead box N2 -2.1289
RALY RALY heterogeneous nuclear ribonucleoprotein -2.12865
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.12635
INPPL1 inositol polyphosphate phosphatase-like 1 -2.12035
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.10795
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.09815
CXCR2 chemokine (C-X-C motif) receptor 2 -2.098
KRT36 keratin 36, type I -2.0775
USP2 ubiquitin specific peptidase 2 -2.07735
GTPBP2 GTP binding protein 2 -2.07005
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.06965
SNTG1 syntrophin, gamma 1 -2.0472
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.03995
GP6 glycoprotein VI (platelet) -2.03885
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.0297
PRELID3B PRELI domain containing 3B -2.0266
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.01605
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.01075