CRCGN011_HEPG2_24H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

263 genes differentially expressed following the CRCGN011_HEPG2_24H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
KLHL21 kelch-like family member 21 10.0
ABHD4 abhydrolase domain containing 4 6.5014
TXNRD1 thioredoxin reductase 1 6.1881
CYCS cytochrome c, somatic 5.998
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.7425
CARMIL1 capping protein regulator and myosin 1 linker 1 5.53645
ADGRE5 adhesion G protein-coupled receptor E5 5.4633
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.2745
NOTCH1 notch 1 5.0781
EPHB2 EPH receptor B2 5.03969
NMU neuromedin U 4.64775
TLR4 toll-like receptor 4 4.5919
CCDC92 coiled-coil domain containing 92 4.5742
CHEK2 checkpoint kinase 2 4.50585
MSRA methionine sulfoxide reductase A 4.41495
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.21015
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.2101
UGDH UDP-glucose 6-dehydrogenase 3.9643
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.959
DYNLT3 dynein, light chain, Tctex-type 3 3.71375
SQSTM1 sequestosome 1 3.58667
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.57355
HMOX1 heme oxygenase 1 3.4585
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.36098
RNF167 ring finger protein 167 3.16185
PRDM8 PR domain containing 8 3.11525
POU3F3 POU class 3 homeobox 3 3.11085
SHH sonic hedgehog 3.086
AANAT aralkylamine N-acetyltransferase 3.0627
GPX2 glutathione peroxidase 2 3.0076
ADAT1 adenosine deaminase, tRNA-specific 1 3.0049
MCPH1 microcephalin 1 2.9456
SSBP2 single-stranded DNA binding protein 2 2.94373
OXT oxytocin/neurophysin I prepropeptide 2.87955
NAPSA napsin A aspartic peptidase 2.87905
SMIM40 small integral membrane protein 40 2.86
CLCN2 chloride channel, voltage-sensitive 2 2.8532
HSPA1A heat shock 70kDa protein 1A 2.8141
FBXO46 F-box protein 46 2.79655
EPHA3 EPH receptor A3 2.78392
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.7762
DGKQ diacylglycerol kinase, theta 110kDa 2.75135
TFCP2L1 transcription factor CP2-like 1 2.7173
TMEM38B transmembrane protein 38B 2.71165
GRB10 growth factor receptor-bound protein 10 2.70983
STATH statherin 2.66865
KDM4D lysine (K)-specific demethylase 4D 2.66515
CAPN15 calpain 15 2.65125
STEEP1 STING1 ER exit protein 1 2.64555
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.6373
PDZD7 PDZ domain containing 7 2.58255
PRLH prolactin releasing hormone 2.5708
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.565
MROH7 maestro heat-like repeat family member 7 2.55055
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.5484
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.54505
DEPDC5 DEP domain containing 5 2.52985
HAPLN2 hyaluronan and proteoglycan link protein 2 2.5206
SHOX short stature homeobox 2.5189
DIPK1A divergent protein kinase domain 1A 2.51455
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.50023
PLCH2 phospholipase C, eta 2 2.48685
MAB21L2 mab-21-like 2 (C. elegans) 2.47487
ACE2 angiotensin I converting enzyme 2 2.44423
UBE2M ubiquitin-conjugating enzyme E2M 2.4307
SMR3B submaxillary gland androgen regulated protein 3B 2.42858
CBX7 chromobox homolog 7 2.407
NANOS3 nanos homolog 3 (Drosophila) 2.40175
PIR pirin (iron-binding nuclear protein) 2.4014
PHAF1 phagosome assembly factor 1 2.40135
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.3973
LMX1B LIM homeobox transcription factor 1, beta 2.3955
PARL presenilin associated, rhomboid-like 2.3892
MYH13 myosin, heavy chain 13, skeletal muscle 2.3889
CPTP ceramide-1-phosphate transfer protein 2.38785
MRPL37 mitochondrial ribosomal protein L37 2.3863
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.3851
IKZF4 IKAROS family zinc finger 4 (Eos) 2.38165
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.3813
ZMYM1 zinc finger, MYM-type 1 2.3574
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.3544
PDCD1LG2 programmed cell death 1 ligand 2 2.3491
SPATA31A3 SPATA31 subfamily A, member 3 2.34845
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like 2.3219
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.3131
H2BC15 H2B clustered histone 15 2.302
DKKL1 dickkopf-like 1 2.29045
FAT4 FAT atypical cadherin 4 2.2901
BZW2 basic leucine zipper and W2 domains 2 2.2899
GALR2 galanin receptor 2 2.27715
HIC1 hypermethylated in cancer 1 2.27565
UTP11 UTP11 small subunit processome component 2.2678
GCM1 glial cells missing homolog 1 (Drosophila) 2.2592
RAX retina and anterior neural fold homeobox 2.2522
ACTL7A actin-like 7A 2.24645
TCF15 transcription factor 15 (basic helix-loop-helix) 2.24585
NECTIN4 nectin cell adhesion molecule 4 2.24525
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.24245
RBMXL2 RNA binding motif protein, X-linked-like 2 2.23725
ADRA1D adrenoceptor alpha 1D 2.23703
MINAR1 membrane integral NOTCH2 associated receptor 1 2.22355
KLF11 Kruppel-like factor 11 2.21795
GJA3 gap junction protein, alpha 3, 46kDa 2.2176
FOXN1 forkhead box N1 2.2166
RABEPK Rab9 effector protein with kelch motifs 2.2144
PAX7 paired box 7 2.21205
BAMBI BMP and activin membrane-bound inhibitor 2.21205
OXCT2 3-oxoacid CoA transferase 2 2.21155
CCR9 chemokine (C-C motif) receptor 9 2.2104
EFNA2 ephrin-A2 2.21
CDX4 caudal type homeobox 4 2.20935
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.2081
PDE7B phosphodiesterase 7B 2.20675
ISCA1 iron-sulfur cluster assembly 1 2.20565
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.20435
SSX5 synovial sarcoma, X breakpoint 5 2.20045
VAMP3 vesicle-associated membrane protein 3 2.19937
ASCL2 achaete-scute family bHLH transcription factor 2 2.19335
FFAR3 free fatty acid receptor 3 2.1865
PCDHA10 protocadherin alpha 10 2.18415
GSR glutathione reductase 2.18205
APOA4 apolipoprotein A-IV 2.17265
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.17265
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.1674
ELL elongation factor RNA polymerase II 2.163
KIAA0513 KIAA0513 2.15875
CTF1 cardiotrophin 1 2.15715
DMRT1 doublesex and mab-3 related transcription factor 1 2.15645
SYNDIG1 synapse differentiation inducing 1 2.1553
TCP11 t-complex 11, testis-specific 2.15385
ESRRA estrogen-related receptor alpha 2.14823
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.14795
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.14558
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.1425
CAPN10 calpain 10 2.1279
FOLR3 folate receptor 3 (gamma) 2.12715
CHN1 chimerin 1 2.12695
LAX1 lymphocyte transmembrane adaptor 1 2.1266
FOXC2 forkhead box C2 2.1252
SMR3A submaxillary gland androgen regulated protein 3A 2.1192
PORCN porcupine homolog (Drosophila) 2.11835
ASIC3 acid sensing (proton gated) ion channel 3 2.1143
GSG1 germ cell associated 1 2.10955
LGALS4 lectin, galactoside-binding, soluble, 4 2.10955
GPR135 G protein-coupled receptor 135 2.10668
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.10567
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.10045
PYGO1 pygopus family PHD finger 1 2.10035
PRM2 protamine 2 2.0995
LBX1 ladybird homeobox 1 2.09405
ZNF778 zinc finger protein 778 2.094
FUT2 fucosyltransferase 2 (secretor status included) 2.09383
PRICKLE3 prickle homolog 3 (Drosophila) 2.0922
TRIM11 tripartite motif containing 11 2.0885
SH3BP1 SH3-domain binding protein 1 2.0859
CATSPERZ catsper channel auxiliary subunit zeta 2.08305
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.081
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.0809
SCT secretin 2.07895
BRDT bromodomain, testis-specific 2.0774
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.07725
YOD1 YOD1 deubiquitinase 2.0744
HTN3 histatin 3 2.07425
MVB12B multivesicular body subunit 12B 2.0733
CBX2 chromobox homolog 2 2.07295
RXYLT1 ribitol xylosyltransferase 1 2.07288
HCRT hypocretin (orexin) neuropeptide precursor 2.07255
FOXD3 forkhead box D3 2.0714
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.0672
FNDC8 fibronectin type III domain containing 8 2.06595
PRH1 proline-rich protein HaeIII subfamily 1 2.06525
TSSK1B testis-specific serine kinase 1B 2.06175
DOCK5 dedicator of cytokinesis 5 2.0612
GPR162 G protein-coupled receptor 162 2.0602
GPR39 G protein-coupled receptor 39 2.05865
TENT5C terminal nucleotidyltransferase 5C 2.05835
KLK14 kallikrein-related peptidase 14 2.05805
ARC activity-regulated cytoskeleton-associated protein 2.0576
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.05667
YBX2 Y box binding protein 2 2.0553
VASP vasodilator-stimulated phosphoprotein 2.0531
H2AP H2A.P histone 2.05175
WDR62 WD repeat domain 62 2.0511
AKAP4 A kinase (PRKA) anchor protein 4 2.05065
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.0504
EP300 E1A binding protein p300 2.0483
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.04465
AKAP3 A kinase (PRKA) anchor protein 3 2.04455
ATOSB atos homolog B 2.0438
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.0437
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.04135
CFAP46 cilia and flagella associated protein 46 2.04075
CNTN2 contactin 2 (axonal) 2.03825
ATOH1 atonal homolog 1 (Drosophila) 2.03765
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.0373
TPSD1 tryptase delta 1 2.0339
PARM1 prostate androgen-regulated mucin-like protein 1 2.033
AVIL advillin 2.0303
CRISP2 cysteine-rich secretory protein 2 2.02615
ZNF222 zinc finger protein 222 2.0235
HOXB1 homeobox B1 2.02295
TREX2 three prime repair exonuclease 2 2.02125
ZNRF4 zinc and ring finger 4 2.0188
CASS4 Cas scaffolding protein family member 4 2.01475
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.0141
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.0138
POGLUT1 protein O-glucosyltransferase 1 2.00825
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.00785
NPAS1 neuronal PAS domain protein 1 2.00542
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.0053
FAAP20 FA core complex associated protein 20 2.00475
HOXA3 homeobox A3 2.00425
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.0031
ZNF343 zinc finger protein 343 2.00235
TMEM19 transmembrane protein 19 2.00165

decreased expression

Symbol Name Standardized Value
RFC2 replication factor C (activator 1) 2, 40kDa -6.73423
ACAA1 acetyl-CoA acyltransferase 1 -5.86447
CD320 CD320 molecule -5.654
PUF60 poly-U binding splicing factor 60KDa -5.4489
THAP11 THAP domain containing 11 -5.2821
TRIB3 tribbles pseudokinase 3 -5.0
LDHD lactate dehydrogenase D -4.93835
CCNB2 cyclin B2 -4.7998
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.78415
CHMP4B charged multivesicular body protein 4B -4.41597
ADI1 acireductone dioxygenase 1 -4.13955
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.9073
GNAS GNAS complex locus -3.7353
CDC25B cell division cycle 25B -3.4955
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.48375
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.9815
OXA1L oxidase (cytochrome c) assembly 1-like -2.67585
FBXL12 F-box and leucine-rich repeat protein 12 -2.655
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.58323
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.56095
DEK DEK proto-oncogene -2.52095
ISOC1 isochorismatase domain containing 1 -2.49695
CD2AP CD2-associated protein -2.47935
NMI N-myc (and STAT) interactor -2.4442
TPGS1 tubulin polyglutamylase complex subunit 1 -2.4369
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.40765
HMGA2 high mobility group AT-hook 2 -2.3568
PGM3 phosphoglucomutase 3 -2.34987
CENPE centromere protein E, 312kDa -2.27895
TOP2B topoisomerase (DNA) II beta 180kDa -2.278
EIF4H eukaryotic translation initiation factor 4H -2.26655
NCAPD2 non-SMC condensin I complex, subunit D2 -2.25285
RWDD2A RWD domain containing 2A -2.2246
ZC2HC1A zinc finger, C2HC-type containing 1A -2.1987
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.1871
DCK deoxycytidine kinase -2.1829
ACLY ATP citrate lyase -2.15758
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.151
MAIP1 matrix AAA peptidase interacting protein 1 -2.1493
TMEM187 transmembrane protein 187 -2.1442
AURKB aurora kinase B -2.13635
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.1241
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.0607
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.06045
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.0378
KIF14 kinesin family member 14 -2.00905
PDIA6 protein disulfide isomerase family A, member 6 -2.00846