| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4-nitro-o-phenylenediamine 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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145 genes differentially expressed following the CRCGN011_HEPG2_24H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD6 | abhydrolase domain containing 6 | 8.13453 |
| TXNRD1 | thioredoxin reductase 1 | 7.1968 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.2431 |
| CTSL | cathepsin L | 5.19705 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.10855 |
| SQOR | sulfide quinone oxidoreductase | 5.10735 |
| LAGE3 | L antigen family, member 3 | 5.104 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.08415 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.07895 |
| CHMP6 | charged multivesicular body protein 6 | 5.03805 |
| CSK | c-src tyrosine kinase | 4.66275 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 4.6312 |
| TLR4 | toll-like receptor 4 | 4.4639 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.4288 |
| STK10 | serine/threonine kinase 10 | 4.37385 |
| ABHD4 | abhydrolase domain containing 4 | 4.2546 |
| HMOX1 | heme oxygenase 1 | 4.1507 |
| CHN1 | chimerin 1 | 3.8784 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 3.839 |
| EVL | Enah/Vasp-like | 3.6054 |
| COL11A1 | collagen, type XI, alpha 1 | 3.5164 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.4475 |
| CCNF | cyclin F | 3.10423 |
| EPN2 | epsin 2 | 2.9848 |
| SQSTM1 | sequestosome 1 | 2.97972 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.92455 |
| PIR | pirin (iron-binding nuclear protein) | 2.89905 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.7536 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.66615 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.6627 |
| ZDHHC24 | zinc finger, DHHC-type containing 24 | 2.645 |
| HSPA1A | heat shock 70kDa protein 1A | 2.6223 |
| CYB561D2 | cytochrome b561 family, member D2 | 2.5186 |
| UPP1 | uridine phosphorylase 1 | 2.51255 |
| CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin | 2.4531 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.4516 |
| BLMH | bleomycin hydrolase | 2.43225 |
| MEST | mesoderm specific transcript | 2.41635 |
| NMU | neuromedin U | 2.4053 |
| TPD52L2 | tumor protein D52-like 2 | 2.3983 |
| TMEM134 | transmembrane protein 134 | 2.3927 |
| RND1 | Rho family GTPase 1 | 2.37995 |
| TMEM268 | transmembrane protein 268 | 2.36335 |
| C1QL1 | complement component 1, q subcomponent-like 1 | 2.3568 |
| RCE1 | Ras converting CAAX endopeptidase 1 | 2.33815 |
| DOLK | dolichol kinase | 2.2878 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.2457 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.24565 |
| EXT2 | exostosin glycosyltransferase 2 | 2.24288 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.23235 |
| NOL8 | nucleolar protein 8 | 2.22335 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 2.205 |
| PAK1IP1 | PAK1 interacting protein 1 | 2.2024 |
| MGST3 | microsomal glutathione S-transferase 3 | 2.19265 |
| CYCS | cytochrome c, somatic | 2.18835 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | 2.18427 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.1317 |
| FASTKD5 | FAST kinase domains 5 | 2.126 |
| MTX2 | metaxin 2 | 2.1226 |
| DPP3 | dipeptidyl-peptidase 3 | 2.11275 |
| PM20D1 | peptidase M20 domain containing 1 | 2.0763 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.065 |
| BAD | BCL2-associated agonist of cell death | 2.06212 |
| HGD | homogentisate 1,2-dioxygenase | 2.05765 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 2.05595 |
| LGSN | lengsin, lens protein with glutamine synthetase domain | 2.051 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 2.04685 |
| KLRC1 | killer cell lectin-like receptor subfamily C, member 1 | 2.04635 |
| NOSIP | nitric oxide synthase interacting protein | 2.0393 |
| SLC67A1 | solute carrier family 67 member 1 | 2.0325 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 2.0315 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.0184 |
| PGC | progastricsin (pepsinogen C) | 2.0097 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 2.00595 |
| CTAGE8 | CTAGE family, member 8 | 2.00163 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| LAP3 | leucine aminopeptidase 3 | -5.61185 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.29885 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -4.92775 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -4.8366 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.8184 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.8174 |
| THAP11 | THAP domain containing 11 | -4.7187 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -4.57585 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.5499 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -4.47497 |
| MAP7 | microtubule-associated protein 7 | -4.2197 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -4.10413 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.99925 |
| PEG10 | paternally expressed 10 | -3.89552 |
| XPO7 | exportin 7 | -3.86492 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.722 |
| GNAS | GNAS complex locus | -3.64505 |
| UGDH | UDP-glucose 6-dehydrogenase | -3.38595 |
| RGS2 | regulator of G-protein signaling 2 | -3.3108 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.20835 |
| PCNA | proliferating cell nuclear antigen | -3.1422 |
| ADI1 | acireductone dioxygenase 1 | -2.9096 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -2.6438 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -2.60005 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -2.5458 |
| CHEK1 | checkpoint kinase 1 | -2.519 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.43999 |
| RTCB | RNA 2',3'-cyclic phosphate and 5'-OH ligase | -2.4169 |
| GPRASP1 | G protein-coupled receptor associated sorting protein 1 | -2.40725 |
| FBXO3 | F-box protein 3 | -2.38435 |
| PRX | periaxin | -2.34815 |
| KIF13B | kinesin family member 13B | -2.326 |
| MAGEF1 | melanoma antigen family F1 | -2.3208 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | -2.27265 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.2661 |
| ZNF253 | zinc finger protein 253 | -2.2624 |
| CCDC69 | coiled-coil domain containing 69 | -2.26055 |
| PRKD3 | protein kinase D3 | -2.2517 |
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | -2.25075 |
| CROT | carnitine O-octanoyltransferase | -2.23275 |
| F2R | coagulation factor II (thrombin) receptor | -2.2117 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.20335 |
| E2F5 | E2F transcription factor 5, p130-binding | -2.19455 |
| TOB2 | transducer of ERBB2, 2 | -2.13842 |
| PHF10 | PHD finger protein 10 | -2.12215 |
| GDPD3 | glycerophosphodiester phosphodiesterase domain containing 3 | -2.1121 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -2.10625 |
| ZNF586 | zinc finger protein 586 | -2.1029 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -2.0786 |
| NGRN | neugrin, neurite outgrowth associated | -2.0751 |
| PRRG4 | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | -2.07505 |
| HMGA2 | high mobility group AT-hook 2 | -2.0686 |
| CNTFR | ciliary neurotrophic factor receptor | -2.0684 |
| POM121 | POM121 transmembrane nucleoporin | -2.0677 |
| FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 | -2.06565 |
| IL19 | interleukin 19 | -2.0642 |
| IMP4 | IMP4, U3 small nucleolar ribonucleoprotein | -2.0582 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | -2.0568 |
| RHOT2 | ras homolog family member T2 | -2.05267 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -2.05203 |
| NUBPL | nucleotide binding protein-like | -2.0416 |
| TRAPPC4 | trafficking protein particle complex 4 | -2.03075 |
| AMT | aminomethyltransferase | -2.0266 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -2.02117 |
| TSPYL1 | TSPY-like 1 | -2.0181 |
| RFTN1 | raftlin, lipid raft linker 1 | -2.01535 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -2.0125 |
| TNXB | tenascin XB | -2.00583 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -2.00426 |
