CRCGN011_HEPG2_24H:L16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN011_HEPG2_24H:L16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.4963
PEX11A peroxisomal biogenesis factor 11 alpha 5.02652
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.01945
CXCL2 chemokine (C-X-C motif) ligand 2 5.01065
STIMATE STIM activating enhancer 4.93005
CSK c-src tyrosine kinase 4.91515
ADGRE5 adhesion G protein-coupled receptor E5 4.75785
SNAP25 synaptosomal-associated protein, 25kDa 4.70545
TXNRD1 thioredoxin reductase 1 4.66525
UGDH UDP-glucose 6-dehydrogenase 4.6211
SLC75A1 solute carrier family 75 member 1 4.55185
TLR4 toll-like receptor 4 4.54265
CYCS cytochrome c, somatic 4.46675
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.1726
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.0883
PPARG peroxisome proliferator-activated receptor gamma 4.04005
GATA3 GATA binding protein 3 4.01133
ABHD4 abhydrolase domain containing 4 3.79465
NOSIP nitric oxide synthase interacting protein 3.68855
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.3293
TIAM1 T-cell lymphoma invasion and metastasis 1 3.32778
CHN1 chimerin 1 3.3216
NMU neuromedin U 3.19795
LRRTM2 leucine rich repeat transmembrane neuronal 2 3.13135
SNAP91 synaptosomal-associated protein, 91kDa 3.022
DENND2D DENN/MADD domain containing 2D 3.00075
RNFT2 ring finger protein, transmembrane 2 2.9394
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 2.78485
AMDHD2 amidohydrolase domain containing 2 2.7461
TIMP4 TIMP metallopeptidase inhibitor 4 2.71675
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.6816
LRRN3 leucine rich repeat neuronal 3 2.62102
JADE2 jade family PHD finger 2 2.57178
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.4889
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.45618
LCN2 lipocalin 2 2.4248
DACH1 dachshund family transcription factor 1 2.4228
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.39848
GAP43 growth associated protein 43 2.37063
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.35878
TEX10 testis expressed 10 2.3521
CCNF cyclin F 2.35033
SLC25A46 solute carrier family 25, member 46 2.3058
TRIM13 tripartite motif containing 13 2.3047
SQSTM1 sequestosome 1 2.2842
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.2789
TH tyrosine hydroxylase 2.2497
PLPPR4 phospholipid phosphatase related 4 2.24125
KDM4D lysine (K)-specific demethylase 4D 2.2355
MRPS22 mitochondrial ribosomal protein S22 2.2161
GPATCH3 G patch domain containing 3 2.2132
TLR7 toll-like receptor 7 2.18485
GRIK1 glutamate receptor, ionotropic, kainate 1 2.16057
STMN2 stathmin 2 2.16013
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.1038
APH1B APH1B gamma secretase subunit 2.0973
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.09595
KEAP1 kelch-like ECH-associated protein 1 2.09365
TUFM Tu translation elongation factor, mitochondrial 2.0851
STAC SH3 and cysteine rich domain 2.0847
C3AR1 complement component 3a receptor 1 2.07585
ABHD14A abhydrolase domain containing 14A 2.07555
DCX doublecortin 2.07538
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.0716
DHDDS dehydrodolichyl diphosphate synthase 2.06515
TRIM36 tripartite motif containing 36 2.06505
EPHA3 EPH receptor A3 2.06022
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.05435
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.0542
BHLHE41 basic helix-loop-helix family, member e41 2.0433
SPA17 sperm autoantigenic protein 17 2.0433
MAN2B2 mannosidase, alpha, class 2B, member 2 2.03995
IFI44L interferon-induced protein 44-like 2.03965
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.03825
ADORA3 adenosine A3 receptor 2.0257
SERF1A small EDRK-rich factor 1A (telomeric) 2.0256
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.02385
KIF21B kinesin family member 21B 2.02345
SCG3 secretogranin III 2.0181
RAB5IF RAB5 interacting factor 2.01635
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing 2.01125
CRLF3 cytokine receptor-like factor 3 2.0084

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.24755
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.1479
DNM1L dynamin 1-like -5.03645
ADI1 acireductone dioxygenase 1 -4.8959
CDC20 cell division cycle 20 -4.8315
ARID5B AT rich interactive domain 5B (MRF1-like) -4.461
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.13875
GNAS GNAS complex locus -3.19694
ELOVL6 ELOVL fatty acid elongase 6 -3.01213
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.9976
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.8724
MYL9 myosin, light chain 9, regulatory -2.86185
TLCD3A TLC domain containing 3A -2.71745
PTK7 protein tyrosine kinase 7 (inactive) -2.5548
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.46055
ROGDI rogdi homolog (Drosophila) -2.45505
KRT8 keratin 8, type II -2.4382
CASP8AP2 caspase 8 associated protein 2 -2.40165
TSPYL2 TSPY-like 2 -2.39325
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.3503
MSL1 male-specific lethal 1 homolog (Drosophila) -2.2847
MSH6 mutS homolog 6 -2.26782
FSTL1 follistatin-like 1 -2.2537
GALT galactose-1-phosphate uridylyltransferase -2.2303
FNBP4 formin binding protein 4 -2.19025
CA2 carbonic anhydrase II -2.189
ZNF500 zinc finger protein 500 -2.17583
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.11495
P3H1 prolyl 3-hydroxylase 1 -2.10945
PRPF39 pre-mRNA processing factor 39 -2.1081
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.10185
NKX3-2 NK3 homeobox 2 -2.09305
FNDC3B fibronectin type III domain containing 3B -2.07045
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.0518
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.0518
RBBP7 retinoblastoma binding protein 7 -2.05125
MCOLN3 mucolipin 3 -2.04225
ANXA8L1 annexin A8-like 1 -2.0306
WDR70 WD repeat domain 70 -2.02465
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.02167
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.01915
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -2.01425
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.0058
DNASE1 deoxyribonuclease I -2.0038
TCEA2 transcription elongation factor A (SII), 2 -2.0001