CRCGN011_HEPG2_24H:L17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

142 genes differentially expressed following the CRCGN011_HEPG2_24H:L17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 6.47875
PCDHB11 protocadherin beta 11 5.69841
LAGE3 L antigen family, member 3 5.55435
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.3383
E2F2 E2F transcription factor 2 5.02295
LYN LYN proto-oncogene, Src family tyrosine kinase 4.99287
PNKP polynucleotide kinase 3'-phosphatase 4.9045
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.7576
UBQLN2 ubiquilin 2 4.62055
TXNRD1 thioredoxin reductase 1 4.5229
NOTCH1 notch 1 4.3659
STK10 serine/threonine kinase 10 4.33317
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.07105
ABHD4 abhydrolase domain containing 4 4.0302
UGDH UDP-glucose 6-dehydrogenase 3.9643
KLHL9 kelch-like family member 9 3.9402
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.75828
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.674
CHN1 chimerin 1 3.569
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.448
VAV3 vav 3 guanine nucleotide exchange factor 3.39462
PRKCH protein kinase C, eta 3.23253
PRR15L proline rich 15-like 3.1983
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.19075
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 3.17825
CCNF cyclin F 3.1648
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 3.0976
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.04367
ZCCHC2 zinc finger, CCHC domain containing 2 2.7481
KEAP1 kelch-like ECH-associated protein 1 2.67215
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.6678
DHDDS dehydrodolichyl diphosphate synthase 2.66132
JADE2 jade family PHD finger 2 2.65762
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.6531
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.62045
GARRE1 granule associated Rac and RHOG effector 1 2.5841
ADAT1 adenosine deaminase, tRNA-specific 1 2.5805
METTL16 methyltransferase like 16 2.5586
SMAD2 SMAD family member 2 2.54807
SQSTM1 sequestosome 1 2.53385
FZD7 frizzled class receptor 7 2.52413
MIS18A MIS18 kinetochore protein A 2.5058
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.43625
TPGS2 tubulin polyglutamylase complex subunit 2 2.43378
TXNL1 thioredoxin-like 1 2.3482
RIPPLY3 ripply transcriptional repressor 3 2.32605
MAGEA6 melanoma antigen family A6 2.31908
TESC tescalcin 2.28715
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.25793
CSNK1A1 casein kinase 1, alpha 1 2.25492
LGSN lengsin, lens protein with glutamine synthetase domain 2.2314
SFTPB surfactant protein B 2.23037
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.22697
CD7 CD7 molecule 2.22533
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.2246
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.22235
CEP170 centrosomal protein 170kDa 2.21385
CAPNS1 calpain, small subunit 1 2.208
SS18 synovial sarcoma translocation, chromosome 18 2.17754
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.1599
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.15915
SMAD4 SMAD family member 4 2.14783
DOCK5 dedicator of cytokinesis 5 2.1134
TACC3 transforming, acidic coiled-coil containing protein 3 2.1056
EI24 etoposide induced 2.4 2.09295
SPATA6L spermatogenesis associated 6-like 2.0828
SSRP1 structure specific recognition protein 1 2.07452
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.06355
PROSER1 proline and serine rich 1 2.0609
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.06047
ZNF696 zinc finger protein 696 2.05455
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.0543
RBFA ribosome binding factor A (putative) 2.0457
NTM neurotrimin 2.03965
KLHL21 kelch-like family member 21 2.03845
KIF3C kinesin family member 3C 2.03535
MAGEA10 melanoma antigen family A10 2.0348
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.03365
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.029
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.0153
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.0136
RFXANK regulatory factor X-associated ankyrin-containing protein 2.012
TLK1 tousled-like kinase 1 2.00598
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.00135

decreased expression

Symbol Name Standardized Value
GTPBP8 GTP-binding protein 8 (putative) -10.0
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
LDHD lactate dehydrogenase D -4.97195
MRPS2 mitochondrial ribosomal protein S2 -4.87585
CD320 CD320 molecule -4.7772
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.74405
KDM3A lysine (K)-specific demethylase 3A -4.65
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.5685
MAP7 microtubule-associated protein 7 -4.56458
ADI1 acireductone dioxygenase 1 -4.54455
CTSD cathepsin D -4.41035
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.50157
NGRN neugrin, neurite outgrowth associated -3.44465
RAI14 retinoic acid induced 14 -3.3934
ABHD10 abhydrolase domain containing 10 -3.1707
ACAA1 acetyl-CoA acyltransferase 1 -3.15508
PCNA proliferating cell nuclear antigen -2.99145
MAPK13 mitogen-activated protein kinase 13 -2.9415
SLC35A5 solute carrier family 35, member A5 -2.7994
ACVR2B activin A receptor, type IIB -2.7804
FBXO3 F-box protein 3 -2.6814
MUC6 mucin 6, oligomeric mucus/gel-forming -2.6181
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.6091
ITGB7 integrin, beta 7 -2.55295
CRBN cereblon -2.4949
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.43205
TMEM39A transmembrane protein 39A -2.4069
CSTA cystatin A (stefin A) -2.3459
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.3418
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.3155
MRPS10 mitochondrial ribosomal protein S10 -2.29605
EPHA1 EPH receptor A1 -2.2818
ZBED2 zinc finger, BED-type containing 2 -2.27985
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.26145
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.24003
GOLGB1 golgin B1 -2.21658
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.21095
PRSS22 protease, serine, 22 -2.20075
TTC13 tetratricopeptide repeat domain 13 -2.1866
ZDHHC13 zinc finger, DHHC-type containing 13 -2.16125
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.15095
ITGB1BP1 integrin beta 1 binding protein 1 -2.1348
KLK11 kallikrein-related peptidase 11 -2.1149
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.11075
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.09175
ZNF12 zinc finger protein 12 -2.0784
TMEM74B transmembrane protein 74B -2.07495
FBXO46 F-box protein 46 -2.0728
BGLAP bone gamma-carboxyglutamate (gla) protein -2.0625
PSRC1 proline/serine-rich coiled-coil 1 -2.0623
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.05175
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.04225
C1GALT1C1 C1GALT1-specific chaperone 1 -2.042
AMOTL2 angiomotin like 2 -2.0282
NPDC1 neural proliferation, differentiation and control, 1 -2.0149
KRT6B keratin 6B, type II -2.01295
DDR2 discoidin domain receptor tyrosine kinase 2 -2.00395
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.0