CRCGN011_HEPG2_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description retrorsine 19.35 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN011_HEPG2_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 7.0535
CDPF1 cysteine-rich, DPF motif domain containing 1 5.12215
EVL Enah/Vasp-like 4.08495
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.0466
ATP11B ATPase, class VI, type 11B 4.02205
MAP7 microtubule-associated protein 7 3.6415
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.47635
PTK2 protein tyrosine kinase 2 3.34845
COQ8A coenzyme Q8A 3.2882
TIAM1 T-cell lymphoma invasion and metastasis 1 3.08615
SHB Src homology 2 domain containing adaptor protein B 3.02955
SNX7 sorting nexin 7 2.70625
LCN2 lipocalin 2 2.66325
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.6238
CHN1 chimerin 1 2.58015
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.50625
IFT20 intraflagellar transport 20 2.38725
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.3195
SRSF9 serine/arginine-rich splicing factor 9 2.1885
IMPACT impact RWD domain protein 2.1809
GCN1 GCN1 activator of EIF2AK4 2.18005
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.1777
ADGRE5 adhesion G protein-coupled receptor E5 2.14845
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.03845
GATA2 GATA binding protein 2 2.03507

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -4.8733
PCNA proliferating cell nuclear antigen -4.7455
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.71785
ADI1 acireductone dioxygenase 1 -4.70095
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.5331
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.49625
FGFR4 fibroblast growth factor receptor 4 -4.3347
SLC35F2 solute carrier family 35, member F2 -4.30935
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.16165
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.93895
OXA1L oxidase (cytochrome c) assembly 1-like -3.63815
GNAS GNAS complex locus -3.53169
RBM15B RNA binding motif protein 15B -2.85475
MAPK13 mitogen-activated protein kinase 13 -2.7406
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.71598
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.59522
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.5588
EIF5 eukaryotic translation initiation factor 5 -2.51052
RNF167 ring finger protein 167 -2.43265
DEPDC5 DEP domain containing 5 -2.3727
CCNH cyclin H -2.35345
PEG10 paternally expressed 10 -2.3432
ITGB1BP1 integrin beta 1 binding protein 1 -2.31522
MAT2B methionine adenosyltransferase II, beta -2.26905
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.22995
WBP1L WW domain binding protein 1-like -2.20345
RMI1 RecQ mediated genome instability 1 -2.1944
MPHOSPH6 M-phase phosphoprotein 6 -2.1797
TRAPPC6A trafficking protein particle complex 6A -2.15125
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 -2.09415
KIFC1 kinesin family member C1 -2.09275
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.0432
ADPRH ADP-ribosylarginine hydrolase -2.03745
WNT10B wingless-type MMTV integration site family, member 10B -2.0141