CRCGN011_HEPG2_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description retrorsine 9.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

105 genes differentially expressed following the CRCGN011_HEPG2_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.00735
MINDY1 MINDY lysine 48 deubiquitinase 1 5.7548
MSRA methionine sulfoxide reductase A 5.1472
ADGRE5 adhesion G protein-coupled receptor E5 5.1278
TREM1 triggering receptor expressed on myeloid cells 1 5.0778
E2F2 E2F transcription factor 2 4.87275
UBQLN2 ubiquilin 2 4.74645
NOTCH1 notch 1 4.6023
STK10 serine/threonine kinase 10 4.43525
MICALL1 MICAL-like 1 3.77975
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.6559
GPER1 G protein-coupled estrogen receptor 1 3.58387
TLR4 toll-like receptor 4 3.5545
SSBP2 single-stranded DNA binding protein 2 3.25793
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.09623
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.9481
PRAF2 PRA1 domain family, member 2 2.88855
HELZ helicase with zinc finger 2.59495
FKBP10 FK506 binding protein 10, 65 kDa 2.51065
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.50115
COQ8A coenzyme Q8A 2.4156
MNT MAX network transcriptional repressor 2.3656
DDIT4 DNA-damage-inducible transcript 4 2.33515
CCDC90B coiled-coil domain containing 90B 2.3286
CHEK2 checkpoint kinase 2 2.31527
BPTF bromodomain PHD finger transcription factor 2.2861
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.24043
PHF21A PHD finger protein 21A 2.2106
FAM8A1 family with sequence similarity 8, member A1 2.20815
TRIOBP TRIO and F-actin binding protein 2.16392
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.14
ZNF587 zinc finger protein 587 2.1339
ING1 inhibitor of growth family, member 1 2.11372
HAUS2 HAUS augmin-like complex, subunit 2 2.1034
JTB jumping translocation breakpoint 2.08077
NPTN neuroplastin 2.0792
CYFIP2 cytoplasmic FMR1 interacting protein 2 2.0723
LYN LYN proto-oncogene, Src family tyrosine kinase 2.06905
ASF1B anti-silencing function 1B histone chaperone 2.06405
TSEN34 TSEN34 tRNA splicing endonuclease subunit 2.05965
USP36 ubiquitin specific peptidase 36 2.04855
ADORA2B adenosine A2b receptor 2.0463
MEST mesoderm specific transcript 2.03715
RAD51D RAD51 paralog D 2.03233
ZNF16 zinc finger protein 16 2.02515

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
CASP3 caspase 3, apoptosis-related cysteine peptidase -5.63915
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.2593
UGDH UDP-glucose 6-dehydrogenase -5.1771
SMNDC1 survival motor neuron domain containing 1 -4.9612
LDHD lactate dehydrogenase D -4.8694
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.7524
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6109
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.60495
MRPS2 mitochondrial ribosomal protein S2 -4.5873
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.385
HSPB1 heat shock 27kDa protein 1 -4.22715
CDC20 cell division cycle 20 -4.2155
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.91978
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.9061
TRAPPC3 trafficking protein particle complex 3 -3.88523
LYPLA1 lysophospholipase I -3.67625
GNAS GNAS complex locus -3.5868
GRWD1 glutamate-rich WD repeat containing 1 -3.5075
OXA1L oxidase (cytochrome c) assembly 1-like -3.282
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.19185
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.09942
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.8451
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.7718
CAPNS1 calpain, small subunit 1 -2.7299
RGS2 regulator of G-protein signaling 2 -2.66485
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.6264
COL15A1 collagen, type XV, alpha 1 -2.57945
SPAG4 sperm associated antigen 4 -2.5325
DSG2 desmoglein 2 -2.51185
MTUS1 microtubule associated tumor suppressor 1 -2.49863
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.4661
TMEM147 transmembrane protein 147 -2.4204
HLA-DMA major histocompatibility complex, class II, DM alpha -2.4024
TOMM34 translocase of outer mitochondrial membrane 34 -2.3649
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.27805
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.26578
MRPS35 mitochondrial ribosomal protein S35 -2.26458
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.2424
CLEC16A C-type lectin domain family 16, member A -2.20585
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.16632
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.1436
ZNF135 zinc finger protein 135 -2.13905
PEX6 peroxisomal biogenesis factor 6 -2.13228
TUFM Tu translation elongation factor, mitochondrial -2.1321
SNRPC small nuclear ribonucleoprotein polypeptide C -2.1143
SERHL2 serine hydrolase-like 2 -2.1095
LMBR1L limb development membrane protein 1-like -2.10225
RUVBL2 RuvB-like AAA ATPase 2 -2.09145
SPARCL1 SPARC-like 1 (hevin) -2.08785
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08412
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.0703
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.0581
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.05615
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.0433
CCL17 chemokine (C-C motif) ligand 17 -2.0416
IL36RN interleukin 36 receptor antagonist -2.02915
TMEM186 transmembrane protein 186 -2.01945
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.00835
RBM14-RBM4 RBM14-RBM4 readthrough -2.0036