CRCGN011_HEPG2_24H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description retrorsine 4.84 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN011_HEPG2_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 7.9255
LAGE3 L antigen family, member 3 5.5091
E2F2 E2F transcription factor 2 5.1168
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.9609
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.84026
MSRA methionine sulfoxide reductase A 4.75955
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.6924
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.54705
TLR4 toll-like receptor 4 4.41895
CCL2 chemokine (C-C motif) ligand 2 3.69705
ATP11B ATPase, class VI, type 11B 3.60275
STK10 serine/threonine kinase 10 3.40358
WDTC1 WD and tetratricopeptide repeats 1 3.39465
LOC122526780 uncharacterized LOC122526780 3.36585
TIAM1 T-cell lymphoma invasion and metastasis 1 3.1597
CYCS cytochrome c, somatic 3.11855
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.02398
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.8845
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.7237
SSBP2 single-stranded DNA binding protein 2 2.71688
CDC45 cell division cycle 45 2.63515
PIH1D1 PIH1 domain containing 1 2.55185
BCAP31 B-cell receptor-associated protein 31 2.5389
TPD52L2 tumor protein D52-like 2 2.33765
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.28632
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.1866
RAB5B RAB5B, member RAS oncogene family 2.1553
FASTKD5 FAST kinase domains 5 2.1113
SLC75A1 solute carrier family 75 member 1 2.1059
CHN1 chimerin 1 2.09655
ASB9 ankyrin repeat and SOCS box containing 9 2.0797
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.0671
XPOT exportin, tRNA 2.0404
NDE1 nudE neurodevelopment protein 1 2.0317
SFTPB surfactant protein B 2.02232
RHOBTB2 Rho-related BTB domain containing 2 2.00595

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.4925
LDHD lactate dehydrogenase D -4.97195
ARID5B AT rich interactive domain 5B (MRF1-like) -4.9236
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.9179
PCCB propionyl CoA carboxylase, beta polypeptide -4.70125
CD320 CD320 molecule -4.69355
FGFR4 fibroblast growth factor receptor 4 -4.25962
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -4.20375
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.06335
OXA1L oxidase (cytochrome c) assembly 1-like -3.69695
MYL9 myosin, light chain 9, regulatory -2.7892
RNF167 ring finger protein 167 -2.7789
PCNA proliferating cell nuclear antigen -2.77625
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.53612
EIF5 eukaryotic translation initiation factor 5 -2.27869
SUSD6 sushi domain containing 6 -2.18105
LRRC42 leucine rich repeat containing 42 -2.10865
FOS FBJ murine osteosarcoma viral oncogene homolog -2.099
QRICH1 glutamine-rich 1 -2.09895
CSF2 colony stimulating factor 2 (granulocyte-macrophage) -2.07
RGCC regulator of cell cycle -2.05815
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.0144
FAT1 FAT atypical cadherin 1 -2.0141