CRCGN011_HEPG2_24H:L22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description retrorsine 2.42 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN011_HEPG2_24H:L22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.6914
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.56465
NMU neuromedin U 5.3513
KLHL21 kelch-like family member 21 5.3121
LCN2 lipocalin 2 5.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.7908
E2F2 E2F transcription factor 2 4.75805
SNAP25 synaptosomal-associated protein, 25kDa 3.8616
WDTC1 WD and tetratricopeptide repeats 1 3.78002
DYNLT3 dynein, light chain, Tctex-type 3 3.43515
ABHD6 abhydrolase domain containing 6 3.36803
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.35825
BIRC2 baculoviral IAP repeat containing 2 3.1949
SSBP2 single-stranded DNA binding protein 2 3.11735
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.06005
RNF167 ring finger protein 167 2.75625
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.73155
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.653
EPHA3 EPH receptor A3 2.49722
GPER1 G protein-coupled estrogen receptor 1 2.46425
JADE2 jade family PHD finger 2 2.36875
ATAD3A ATPase family, AAA domain containing 3A 2.2453
CACFD1 calcium channel flower domain containing 1 2.24332
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.23885
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.23875
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.22955
KHNYN KH and NYN domain containing 2.20525
KLF15 Kruppel-like factor 15 2.17575
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.16155
LMF2 lipase maturation factor 2 2.12963
TMEM209 transmembrane protein 209 2.10175
PAQR3 progestin and adipoQ receptor family member III 2.09605
SSUH2 ssu-2 homolog (C. elegans) 2.0777
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.07212
KIF5A kinesin family member 5A 2.0581
TMEM222 transmembrane protein 222 2.03592
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.03397
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.0274
STRN3 striatin, calmodulin binding protein 3 2.0237
CALCOCO1 calcium binding and coiled-coil domain 1 2.0184
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.00015

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.39095
LDHD lactate dehydrogenase D -5.1242
GDF15 growth differentiation factor 15 -5.0
PLK1 polo-like kinase 1 -4.7725
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.65675
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.55985
FGFR4 fibroblast growth factor receptor 4 -4.21882
EIF5 eukaryotic translation initiation factor 5 -4.09884
GNAS GNAS complex locus -3.44431
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.27835
PCNA proliferating cell nuclear antigen -3.0928
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.50717
TLCD3A TLC domain containing 3A -2.4719
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.43767
HMG20B high mobility group 20B -2.43455
HJURP Holliday junction recognition protein -2.18715
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.1618
AURKA aurora kinase A -2.11608
LGALS4 lectin, galactoside-binding, soluble, 4 -2.10355
CENPE centromere protein E, 312kDa -2.08915
CCDC88C coiled-coil domain containing 88C -2.0688
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -2.0144