CRCGN011_HEPG2_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description retrorsine 0.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN011_HEPG2_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 10.0
TREM1 triggering receptor expressed on myeloid cells 1 6.1038
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9978
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.927
TLR4 toll-like receptor 4 4.6611
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.47105
MAP7 microtubule-associated protein 7 3.79478
PRKCH protein kinase C, eta 3.3487
NENF neudesin neurotrophic factor 3.33293
PFKL phosphofructokinase, liver 3.32187
PIH1D1 PIH1 domain containing 1 3.22485
CCNA1 cyclin A1 2.95875
FZD7 frizzled class receptor 7 2.8149
SSBP2 single-stranded DNA binding protein 2 2.7215
HSPA14 heat shock 70kDa protein 14 2.5859
HYOU1 hypoxia up-regulated 1 2.4171
KLHL9 kelch-like family member 9 2.40655
GPATCH8 G patch domain containing 8 2.26507
ZNF430 zinc finger protein 430 2.23685
GEMIN6 gem (nuclear organelle) associated protein 6 2.20045
KIAA0319L KIAA0319-like 2.2002
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.16807
TOR3A torsin family 3, member A 2.1629
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.12825
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 2.08555
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.0835
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.04065
TNIP1 TNFAIP3 interacting protein 1 2.04025
ZNF253 zinc finger protein 253 2.02355

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PLK1 polo-like kinase 1 -5.5514
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.76155
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.57335
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.5155
UGDH UDP-glucose 6-dehydrogenase -4.51435
GDF15 growth differentiation factor 15 -4.1186
PCNA proliferating cell nuclear antigen -3.8695
OXA1L oxidase (cytochrome c) assembly 1-like -3.6629
GNAS GNAS complex locus -3.52834
HMG20B high mobility group 20B -3.21915
GRWD1 glutamate-rich WD repeat containing 1 -3.1616
YME1L1 YME1-like 1 ATPase -3.09105
ACAA1 acetyl-CoA acyltransferase 1 -2.76745
LCMT1 leucine carboxyl methyltransferase 1 -2.641
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.6326
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.4771
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.46413
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -2.43435
IL37 interleukin 37 -2.42705
TBCB tubulin folding cofactor B -2.41518
INSL5 insulin-like 5 -2.4114
CROT carnitine O-octanoyltransferase -2.3501
FXYD5 FXYD domain containing ion transport regulator 5 -2.3492
HLA-DMA major histocompatibility complex, class II, DM alpha -2.33155
RBM15B RNA binding motif protein 15B -2.27795
C1RL complement component 1, r subcomponent-like -2.2757
MED4 mediator complex subunit 4 -2.2277
PRAME preferentially expressed antigen in melanoma -2.2246
AKAP13 A kinase (PRKA) anchor protein 13 -2.15803
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.13965
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.13835
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.12305
FMO5 flavin containing monooxygenase 5 -2.10768
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -2.0957
OLFML3 olfactomedin-like 3 -2.09505
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.077
OGN osteoglycin -2.0742
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.06655
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.065
GPR87 G protein-coupled receptor 87 -2.0526
RINT1 RAD50 interactor 1 -2.0496
CD69 CD69 molecule -2.04585
HDAC1 histone deacetylase 1 -2.04335
COPS4 COP9 signalosome subunit 4 -2.02155