CRCGN011_HEPG2_24H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description resorcinol 39.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN011_HEPG2_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 5.10405
CHN1 chimerin 1 4.23065
UBE2L6 ubiquitin-conjugating enzyme E2L 6 4.14585
CHMP6 charged multivesicular body protein 6 4.1104
BZW2 basic leucine zipper and W2 domains 2 3.78585
COL11A1 collagen, type XI, alpha 1 3.55995
FASTKD5 FAST kinase domains 5 3.1973
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.9392
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.808
RALB v-ral simian leukemia viral oncogene homolog B 2.6416
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.61475
CHEK2 checkpoint kinase 2 2.61465
RAB31 RAB31, member RAS oncogene family 2.58288
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.44293
HMGA2 high mobility group AT-hook 2 2.39835
MAGEA6 melanoma antigen family A6 2.34107
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.302
GPATCH8 G patch domain containing 8 2.30058
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.29075
HSPA1A heat shock 70kDa protein 1A 2.2842
ADCY7 adenylate cyclase 7 2.2393
MAGEA2B melanoma antigen family A2B 2.23005
DIPK1A divergent protein kinase domain 1A 2.18915
FPGS folylpolyglutamate synthase 2.18915
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.1167
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.0954
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.021

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.65925
GDF15 growth differentiation factor 15 -5.0
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.93405
PCNA proliferating cell nuclear antigen -4.82295
UGDH UDP-glucose 6-dehydrogenase -4.66275
LDHD lactate dehydrogenase D -4.5952
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.53585
VAT1 vesicle amine transport 1 -4.37745
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.2637
SLC35F2 solute carrier family 35, member F2 -3.56285
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.31305
GNAS GNAS complex locus -3.13454
OXA1L oxidase (cytochrome c) assembly 1-like -3.1185
WASHC4 WASH complex subunit 4 -3.09213
TBC1D31 TBC1 domain family, member 31 -2.61285
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.5581
LARP6 La ribonucleoprotein domain family, member 6 -2.4812
STAMBP STAM binding protein -2.4313
SPAG4 sperm associated antigen 4 -2.37775
CPA4 carboxypeptidase A4 -2.31035
ADIRF adipogenesis regulatory factor -2.2903
ATXN2 ataxin 2 -2.26635
SYNPO synaptopodin -2.188
FICD FIC domain containing -2.1433
CRIP2 cysteine-rich protein 2 -2.1236
RAI14 retinoic acid induced 14 -2.1185
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.11422
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.11205
EPN2 epsin 2 -2.11172
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.1113
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.07495
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.05545
KREMEN2 kringle containing transmembrane protein 2 -2.05445
CTSD cathepsin D -2.04045
CKMT1A creatine kinase, mitochondrial 1A -2.02615
LARP7 La ribonucleoprotein domain family, member 7 -2.0177
NPDC1 neural proliferation, differentiation and control, 1 -2.0041
CD79B CD79b molecule, immunoglobulin-associated beta -2.00305