CRCGN011_HEPG2_24H:M02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description resorcinol 19.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN011_HEPG2_24H:M02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 5.37665
ADRB2 adrenoceptor beta 2, surface 5.21825
BIRC2 baculoviral IAP repeat containing 2 5.11645
PLS1 plastin 1 5.09835
LCN2 lipocalin 2 5.0
UBQLN2 ubiquilin 2 4.9503
PPARG peroxisome proliferator-activated receptor gamma 4.94765
SQOR sulfide quinone oxidoreductase 4.93705
CSK c-src tyrosine kinase 4.91515
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.7801
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.55305
GATA3 GATA binding protein 3 3.79045
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.13645
SSBP2 single-stranded DNA binding protein 2 3.1233
LOC122526780 uncharacterized LOC122526780 2.94195
SATB1 SATB homeobox 1 2.57625
RNF167 ring finger protein 167 2.52895
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.5118
FASTKD5 FAST kinase domains 5 2.50595
SPPL2A signal peptide peptidase like 2A 2.48395
LRRC42 leucine rich repeat containing 42 2.481
PGAM4 phosphoglycerate mutase family member 4 2.36615
GPER1 G protein-coupled estrogen receptor 1 2.26483
BAD BCL2-associated agonist of cell death 2.14038
HMGA2 high mobility group AT-hook 2 2.10755
CCNF cyclin F 2.09605
E2F2 E2F transcription factor 2 2.0938
NNT nicotinamide nucleotide transhydrogenase 2.01898

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.44179
CHMP4B charged multivesicular body protein 4B -4.26888
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.25185
LDHD lactate dehydrogenase D -4.1852
ACAA1 acetyl-CoA acyltransferase 1 -3.93217
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.85805
ADI1 acireductone dioxygenase 1 -3.48695
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.29562
WASHC4 WASH complex subunit 4 -3.28992
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.2273
GRWD1 glutamate-rich WD repeat containing 1 -3.06345
PRND prion protein 2 (dublet) -2.876
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.87511
AASS aminoadipate-semialdehyde synthase -2.77005
FTSJ3 FtsJ homolog 3 (E. coli) -2.74755
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.5602
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 -2.46515
RFC2 replication factor C (activator 1) 2, 40kDa -2.4301
NRIP1 nuclear receptor interacting protein 1 -2.4116
PLAAT1 phospholipase A and acyltransferase 1 -2.39625
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -2.39495
NSD1 nuclear receptor binding SET domain protein 1 -2.3506
BEAN1 brain expressed, associated with NEDD4, 1 -2.34855
RIC3 RIC3 acetylcholine receptor chaperone -2.3118
MYD88 myeloid differentiation primary response 88 -2.29285
KLHL4 kelch-like family member 4 -2.28965
SLC35F2 solute carrier family 35, member F2 -2.26925
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.2627
ITGB1BP1 integrin beta 1 binding protein 1 -2.2605
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.21575
TSPAN13 tetraspanin 13 -2.2023
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.19435
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -2.1924
HELZ helicase with zinc finger -2.18345
TEX14 testis expressed 14 -2.17955
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.1354
PRM2 protamine 2 -2.131
AIRIM AFG2 interacting ribosome maturation factor -2.11295
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.11215
DAZL deleted in azoospermia-like -2.1081
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.10595
SNTG1 syntrophin, gamma 1 -2.105
DEFA6 defensin, alpha 6, Paneth cell-specific -2.1024
TSSK2 testis-specific serine kinase 2 -2.1001
TULP2 tubby like protein 2 -2.0977
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.07345
KCNIP1 Kv channel interacting protein 1 -2.073
ART3 ADP-ribosyltransferase 3 -2.0709
PRDM5 PR domain containing 5 -2.0644
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.06395
SPDEF SAM pointed domain containing ETS transcription factor -2.05647
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.0458
FAM131B family with sequence similarity 131, member B -2.04455
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.04005
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.03175
SOX11 SRY (sex determining region Y)-box 11 -2.02855
DEFA5 defensin, alpha 5, Paneth cell-specific -2.02485
BRDT bromodomain, testis-specific -2.02195
FGF14 fibroblast growth factor 14 -2.0208
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.0203
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 -2.01965
VAV1 vav 1 guanine nucleotide exchange factor -2.008
ZSCAN2 zinc finger and SCAN domain containing 2 -2.00365
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 -2.0025