CRCGN011_HEPG2_24H:M04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description resorcinol 4.88 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN011_HEPG2_24H:M04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.5272
PPARG peroxisome proliferator-activated receptor gamma 5.19735
MCOLN1 mucolipin 1 4.72995
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.71625
NOTCH1 notch 1 4.54585
C2CD2 C2 calcium-dependent domain containing 2 4.4011
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.34585
ABHD4 abhydrolase domain containing 4 4.31905
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.05068
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.66227
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.4825
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.43085
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.96085
LOC122526780 uncharacterized LOC122526780 2.95555
DHDDS dehydrodolichyl diphosphate synthase 2.73377
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.6132
COL11A1 collagen, type XI, alpha 1 2.60612
JADE2 jade family PHD finger 2 2.5699
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.53855
FASTKD5 FAST kinase domains 5 2.4839
COG4 component of oligomeric golgi complex 4 2.4741
CYCS cytochrome c, somatic 2.40875
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.34495
VGLL4 vestigial-like family member 4 2.24222
OSGEP O-sialoglycoprotein endopeptidase 2.23165
DIPK1A divergent protein kinase domain 1A 2.1604
SMAD3 SMAD family member 3 2.1511
TUBA4B tubulin, alpha 4b 2.132
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.08595
CCNF cyclin F 2.0431
SH2D4A SH2 domain containing 4A 2.0387
SRBD1 S1 RNA binding domain 1 2.0307
NHEJ1 nonhomologous end-joining factor 1 2.01585

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.39826
ADI1 acireductone dioxygenase 1 -4.97155
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.95875
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.88695
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.8069
LDHD lactate dehydrogenase D -4.4911
TUBB6 tubulin, beta 6 class V -4.0824
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.87283
CDC25B cell division cycle 25B -3.75895
PCNA proliferating cell nuclear antigen -3.5008
SLC35F2 solute carrier family 35, member F2 -3.41605
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.3928
CCNB2 cyclin B2 -3.24625
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.16805
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.78467
LPAR4 lysophosphatidic acid receptor 4 -2.595
HGFAC HGF activator -2.5155
ZNF460 zinc finger protein 460 -2.497
SERGEF secretion regulating guanine nucleotide exchange factor -2.4002
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.35682
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -2.3342
PDHX pyruvate dehydrogenase complex, component X -2.32852
NINL ninein-like -2.28645
SIPA1 signal-induced proliferation-associated 1 -2.27695
PLXDC1 plexin domain containing 1 -2.27408
AKR1D1 aldo-keto reductase family 1, member D1 -2.1894
OTUD7B OTU deubiquitinase 7B -2.1686
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.16645
BCAP29 B-cell receptor-associated protein 29 -2.1478
TRMT9B tRNA methyltransferase 9B (putative) -2.1308
TIMP1 TIMP metallopeptidase inhibitor 1 -2.11805
SCAMP2 secretory carrier membrane protein 2 -2.11295
CHD3 chromodomain helicase DNA binding protein 3 -2.1118
ADRB1 adrenoceptor beta 1 -2.10445
RYR1 ryanodine receptor 1 (skeletal) -2.0977
CCNK cyclin K -2.09195
SPATA1 spermatogenesis associated 1 -2.03805
BRDT bromodomain, testis-specific -2.0317
NPTN neuroplastin -2.0181
PHF14 PHD finger protein 14 -2.01185
NKX2-2 NK2 homeobox 2 -2.0109