CRCGN011_HEPG2_24H:M05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description resorcinol 2.44 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN011_HEPG2_24H:M05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
CBR3 carbonyl reductase 3 5.5193
STK10 serine/threonine kinase 10 5.2947
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.11365
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.07025
MAMLD1 mastermind-like domain containing 1 4.82595
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7746
AMDHD2 amidohydrolase domain containing 2 4.4651
MOK MOK protein kinase 4.3926
LCN2 lipocalin 2 4.3842
UBQLN2 ubiquilin 2 4.3813
PLS1 plastin 1 4.2321
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.1722
HDGFL3 HDGF like 3 4.04095
BIRC2 baculoviral IAP repeat containing 2 3.9055
DYNLT3 dynein, light chain, Tctex-type 3 3.8568
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.6557
PRR15L proline rich 15-like 3.6396
SPRED2 sprouty-related, EVH1 domain containing 2 3.3246
ALG8 ALG8, alpha-1,3-glucosyltransferase 3.24795
VGLL4 vestigial-like family member 4 2.98633
CCNF cyclin F 2.96317
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.9316
CHN1 chimerin 1 2.8368
SLFN12 schlafen family member 12 2.7408
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.6666
RSF1 remodeling and spacing factor 1 2.48915
SP140L SP140 nuclear body protein-like 2.4733
PRKCH protein kinase C, eta 2.46518
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.46025
JADE2 jade family PHD finger 2 2.43895
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.4264
TRIM66 tripartite motif containing 66 2.3614
GJA1 gap junction protein, alpha 1, 43kDa 2.3512
EPN2 epsin 2 2.33715
SH3D19 SH3 domain containing 19 2.30877
DMBT1 deleted in malignant brain tumors 1 2.28985
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.2764
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.27535
PTH2R parathyroid hormone 2 receptor 2.26775
BTK Bruton agammaglobulinemia tyrosine kinase 2.2668
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.26215
AAMDC adipogenesis associated, Mth938 domain containing 2.20843
SKIC8 SKI8 subunit of superkiller complex 2.20017
FASTKD5 FAST kinase domains 5 2.19535
NKG7 natural killer cell granule protein 7 2.1907
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.1824
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.15727
SDF2L1 stromal cell-derived factor 2-like 1 2.1504
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.1468
BIRC3 baculoviral IAP repeat containing 3 2.124
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.1221
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.10913
RWDD3 RWD domain containing 3 2.1081
ITK IL2-inducible T-cell kinase 2.08545
CPOX coproporphyrinogen oxidase 2.0848
CRELD2 cysteine-rich with EGF-like domains 2 2.071
PKN1 protein kinase N1 2.07017
CDK3 cyclin-dependent kinase 3 2.0558
DGKI diacylglycerol kinase, iota 2.0288
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.02625
IL18 interleukin 18 2.0001

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.3145
USP6NL USP6 N-terminal like -5.72735
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.1403
CDC20 cell division cycle 20 -5.0
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.86035
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.71785
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.69905
YME1L1 YME1-like 1 ATPase -4.20152
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.19255
ZMIZ1 zinc finger, MIZ-type containing 1 -3.84275
TCTN1 tectonic family member 1 -3.5294
HEATR1 HEAT repeat containing 1 -3.44305
CCNB2 cyclin B2 -3.38675
LAGE3 L antigen family, member 3 -3.3063
CAB39 calcium binding protein 39 -3.18155
OXA1L oxidase (cytochrome c) assembly 1-like -2.8438
WASHC4 WASH complex subunit 4 -2.82347
KLHL21 kelch-like family member 21 -2.80615
DSG2 desmoglein 2 -2.72735
PSRC1 proline/serine-rich coiled-coil 1 -2.57105
RGS2 regulator of G-protein signaling 2 -2.5152
LGMN legumain -2.44295
LRRC41 leucine rich repeat containing 41 -2.3822
ATG9A autophagy related 9A -2.3405
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.32795
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.24685
ZNF384 zinc finger protein 384 -2.18815
MAB21L1 mab-21-like 1 (C. elegans) -2.1638
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.15838
CLMN calmin (calponin-like, transmembrane) -2.15758
CHIC2 cysteine-rich hydrophobic domain 2 -2.11015
NPY neuropeptide Y -2.1039
TP53 tumor protein p53 -2.02647
EXD2 exonuclease 3'-5' domain containing 2 -2.01795
ZFHX4 zinc finger homeobox 4 -2.0154