CRCGN011_HEPG2_24H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 4.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN011_HEPG2_24H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.36175
UBQLN2 ubiquilin 2 4.97735
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.83655
PPARG peroxisome proliferator-activated receptor gamma 4.7153
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.52185
CYCS cytochrome c, somatic 4.44535
CXCL2 chemokine (C-X-C motif) ligand 2 3.95805
MAP7 microtubule-associated protein 7 3.88132
CNPY3 canopy FGF signaling regulator 3 3.72375
FZD7 frizzled class receptor 7 3.67412
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.53525
ATP11B ATPase, class VI, type 11B 3.10025
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.7113
SORBS3 sorbin and SH3 domain containing 3 2.66432
CYB561 cytochrome b561 2.6073
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.58485
SKIC2 SKI2 subunit of superkiller complex 2.5249
GPER1 G protein-coupled estrogen receptor 1 2.47808
TBXA2R thromboxane A2 receptor 2.29671
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.22715
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.15825
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.12952
TREM1 triggering receptor expressed on myeloid cells 1 2.11215
MEST mesoderm specific transcript 2.0724
AK8 adenylate kinase 8 2.0529
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.04605
FASTKD5 FAST kinase domains 5 2.0391
FTCD formimidoyltransferase cyclodeaminase 2.02425
ATP5ME ATP synthase membrane subunit e 2.00455

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -5.53475
UGDH UDP-glucose 6-dehydrogenase -5.4105
CCDC86 coiled-coil domain containing 86 -5.33835
LDHD lactate dehydrogenase D -5.26985
CHMP4B charged multivesicular body protein 4B -5.08297
CDC20 cell division cycle 20 -5.0
PYCR1 pyrroline-5-carboxylate reductase 1 -4.96525
CCNB1 cyclin B1 -4.6264
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.57675
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.33345
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.7755
TLCD3A TLC domain containing 3A -3.69495
PGM1 phosphoglucomutase 1 -3.41785
TCERG1 transcription elongation regulator 1 -3.1156
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.03436
ACAA1 acetyl-CoA acyltransferase 1 -2.70415
CCNB2 cyclin B2 -2.6795
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.58037
HLA-DMB major histocompatibility complex, class II, DM beta -2.4845
DERA deoxyribose-phosphate aldolase (putative) -2.4334
PDZRN4 PDZ domain containing ring finger 4 -2.38855
HLA-DMA major histocompatibility complex, class II, DM alpha -2.3058
FAM169A family with sequence similarity 169, member A -2.2856
GDF15 growth differentiation factor 15 -2.2189
GCLC glutamate-cysteine ligase, catalytic subunit -2.19937
C4A complement component 4A (Rodgers blood group) -2.18775
PAGE4 P antigen family, member 4 (prostate associated) -2.1873
USP39 ubiquitin specific peptidase 39 -2.1729
FECH ferrochelatase -2.16685
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -2.15455
RNF167 ring finger protein 167 -2.127
EMC9 ER membrane protein complex subunit 9 -2.0657
TMC5 transmembrane channel-like 5 -2.0512
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.04655
PADI2 peptidyl arginine deiminase, type II -2.0384
VRK1 vaccinia related kinase 1 -2.02745
DCXR dicarbonyl/L-xylulose reductase -2.02225
MYL2 myosin, light chain 2, regulatory, cardiac, slow -2.02125
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.01295
PRPF19 pre-mRNA processing factor 19 -2.00855