CRCGN011_HEPG2_24H:M12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN011_HEPG2_24H:M12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.9951
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0209
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.9609
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.70975
KDM5A lysine (K)-specific demethylase 5A 3.94165
PEX11A peroxisomal biogenesis factor 11 alpha 3.83227
PFKL phosphofructokinase, liver 3.63412
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.49402
MAP7 microtubule-associated protein 7 3.38172
LCN2 lipocalin 2 3.3674
TLR4 toll-like receptor 4 3.3554
GPER1 G protein-coupled estrogen receptor 1 3.22738
SCRN1 secernin 1 3.1569
GADD45A growth arrest and DNA-damage-inducible, alpha 3.1298
CYCS cytochrome c, somatic 2.8444
LOC122526780 uncharacterized LOC122526780 2.7767
PRR15L proline rich 15-like 2.7444
FOXJ3 forkhead box J3 2.7372
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.56165
JADE2 jade family PHD finger 2 2.52457
ZNF589 zinc finger protein 589 2.47798
CDK19 cyclin-dependent kinase 19 2.45795
BMP4 bone morphogenetic protein 4 2.3917
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.3292
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2.30715
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.30385
BIRC2 baculoviral IAP repeat containing 2 2.3003
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.25965
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.1762
DPT dermatopontin 2.16142
CHN1 chimerin 1 2.161
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.1496
CPVL carboxypeptidase, vitellogenic-like 2.1169
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.10945
CCDC47 coiled-coil domain containing 47 2.0997
KLHL9 kelch-like family member 9 2.0863
SKIC2 SKI2 subunit of superkiller complex 2.06785
MTG1 mitochondrial ribosome-associated GTPase 1 2.06075
ZNHIT6 zinc finger, HIT-type containing 6 2.03305

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
TRIB3 tribbles pseudokinase 3 -5.29275
CDC20 cell division cycle 20 -5.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.52445
PCNA proliferating cell nuclear antigen -4.2238
TLCD3A TLC domain containing 3A -3.90535
OXA1L oxidase (cytochrome c) assembly 1-like -3.84485
WDR7 WD repeat domain 7 -3.3368
FASTKD5 FAST kinase domains 5 -3.1454
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.0912
RBM34 RNA binding motif protein 34 -2.76767
SNX11 sorting nexin 11 -2.74612
MTFR1 mitochondrial fission regulator 1 -2.4769
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.4088
RTCA RNA 3'-terminal phosphate cyclase -2.34875
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.1922
NRIP1 nuclear receptor interacting protein 1 -2.1916
PRPF4 pre-mRNA processing factor 4 -2.16795
NDP Norrie disease (pseudoglioma) -2.1637
CALCB calcitonin-related polypeptide beta -2.1426
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1235
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.0257
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -2.02063
NCF2 neutrophil cytosolic factor 2 -2.01955